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Entry version 146 (12 Aug 2020)
Sequence version 4 (31 Jan 2018)
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Protein

Soluble guanylate cyclase 88E

Gene

Gyc88E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.1 Publication

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 1 or 2 heme groups per heterodimer.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Probably not activated by nitric oxide (NO). Homodimer is slightly stimulated by the NO donor sodium nitroprusside (SNP) but not the NO donor DEA-NONOate or the NO-independent activator YC-1. Heterodimer also exhibits some stimulation, some compounds (SIN-1 and two of the NONOates) that were ineffective at stimulating Gyc-88E alone did stimulate the heterodimer.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi104Iron (heme proximal ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Heme, Iron, Magnesium, Manganese, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Soluble guanylate cyclase 88E (EC:4.6.1.2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gyc88EImported
ORF Names:CG4154Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0038295, Gyc88E

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000741051 – 1097Soluble guanylate cyclase 88EAdd BLAST1097

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8INF0

PRoteomics IDEntifications database

More...
PRIDEi
Q8INF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryos in a segmental pattern in the ventral nerve cord (VNC) and in the brain, beginning at stage 15 or 16 and continuing through to stage 1. Colocalized with Gyc-89Db in several peripheral neurons that innervate trachea, basiconical sensilla and the sensory cones in the posterior segments of the embryo. Expression in wandering third instar larvae is most prominent in a small cluster of cells located in the anterior medial region of each brain lobe. In the VNC, expression is found in scattered cells both laterally and at the midline.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos, larvae and adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0038295, Expressed in neuron and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8INF0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8INF0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer; with Gyc-89Db and Gyc-89Da, in the presence of magnesium or manganese.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8INF0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0110261

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8INF0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini421 – 549Guanylate cyclasePROSITE-ProRule annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili354 – 392Sequence analysisAdd BLAST39
Coiled coili960 – 987Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi611 – 639Pro-richPROSITE-ProRule annotationAdd BLAST29
Compositional biasi669 – 715Ala-richPROSITE-ProRule annotationAdd BLAST47
Compositional biasi804 – 848Pro-richPROSITE-ProRule annotationAdd BLAST45
Compositional biasi1041 – 1090His-richPROSITE-ProRule annotationAdd BLAST50

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4171, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165461

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8INF0

KEGG Orthology (KO)

More...
KOi
K01769

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHEVESQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8INF0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.450.260, 1 hit
3.30.70.1230, 1 hit
3.90.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR038158, H-NOX_domain_sf
IPR011644, Heme_NO-bd
IPR011645, HNOB_dom_associated
IPR042463, HNOB_dom_associated_sf
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR029787, Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF07700, HNOB, 1 hit
PF07701, HNOBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044, CYCc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111126, SSF111126, 1 hit
SSF55073, SSF55073, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform DImported (identifier: Q8INF0-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication, EImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGLLLENLS EYIKSVYGEE KWEDIRRQAG IDSPSFSVHQ VYPENLLQKL
60 70 80 90 100
AKKAQQVLGV SERDFMDQMG VYFVGFVGQY GYDRVLSVLG RHMRDFLNGL
110 120 130 140 150
DNLHEYLKFS YPRMRAPSFI CENETKQGLT LHYRSKRRGF VYYTMGQIRE
160 170 180 190 200
VARYFYHKEM HIELVREEIL FDTVHVTFQL TFDNRAFTLA SLAMTREEKH
210 220 230 240 250
LPISAHVLFE IFPFCMVFGA DMVVRSIGNS LMVILPELLG KKITAWFDLV
260 270 280 290 300
RPLIAFKFQT ILNRTNNIFE LVTVDPVTER FDVQNEDLLQ HEDGSEPEKS
310 320 330 340 350
LRLKGQMVYM ENWRMIMFLG TPVMPDLTSL ITTGLYINDL SMHDFSRDLM
360 370 380 390 400
LAGTQQSVEL KLALDQEQQK SKKLEESMRL LDEEMRRTDE LLYQMIPKQV
410 420 430 440 450
ADRLRRGENP IDTCEMFDSV SILFSDIVTF TEICSRITPM EVVSMLNAMY
460 470 480 490 500
SIFDKLTERN SVYKVETIGD AYMVVAGAPD KDANHAERVC DMALDMVDAI
510 520 530 540 550
TDLKDPSTGQ HLRIRVGVHS GAVVAGIVGL KMPRYCLFGD TVNTASRMES
560 570 580 590 600
TSIAMKVHIS ESTKVLIGPN YKIIERGEID VKGKGTMGTY WLEERENRLP
610 620 630 640 650
LQLTAALQVH PLSPVPPTPT PKTKAIMPPV SKPLTPMMPV SVSLAASMPT
660 670 680 690 700
SNVPAVDVMA SSSSISGLAL TAAAAAHMSL HHQAVVAEAL TGASVEVALP
710 720 730 740 750
SVASGATGAA AGGGAPSDDR NSRIYSPVTF KDVARRSVAN SPVRSCAQPD
760 770 780 790 800
QERRRESRSN STGHVFMRTP SEIFGSLILD TEEFLEDLQI SRSSLANNNN
810 820 830 840 850
NQSPCGFSPT PPFRIGSAPP KPRPSNPDKF TPEELAAMDQ LTPPSTAPAR
860 870 880 890 900
ETASCSSASL DRDKATKLKK ITFSNSSSLD ATTPTALAAV VCPMRTKSPP
910 920 930 940 950
MAVAPVMHMV QASTSKGDGQ RPGSKDSVSS ISLHSPPPHR SNSAPARPHS
960 970 980 990 1000
MSKAARKAFL AAKQTKAMEK LDKMIEEVQE VESQSVAKAA NMRLALYGHD
1010 1020 1030 1040 1050
GGGDLAAGGC PLFLPPPPQQ QQQQQQSLMP SSISDSGLCS HGHSHAPSCH
1060 1070 1080 1090
HMDPKMTNSQ SFQHSPRGGI THQCCSGFGH GNGRHSHRMH SNACRIL
Length:1,097
Mass (Da):121,201
Last modified:January 31, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF93CF321C8AC1C0
GO
Isoform F (identifier: Q8INF0-2) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     869-876: KKITFSNS → N

Show »
Length:1,090
Mass (Da):120,409
Checksum:i82D90E0BEF5625FD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ84038 differs from that shown. Probable cloning artifact.Curated
The sequence AAQ84039 differs from that shown. Probable cloning artifact.Curated
The sequence ABM92811 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti876S → SS in AAQ84038 (PubMed:15159437).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051918869 – 876KKITFSNS → N in isoform F. Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55135.5
AE014297 Genomic DNA Translation: ABI31167.1
AE014297 Genomic DNA Translation: AFH06433.1
BT029937 mRNA Translation: ABM92811.1 Frameshift.
AY376404 mRNA Translation: AAQ84038.1 Sequence problems.
AY376405 mRNA Translation: AAQ84039.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001036711.1, NM_001043246.4 [Q8INF0-1]
NP_001247115.1, NM_001260186.2 [Q8INF0-1]
NP_731974.4, NM_169616.4 [Q8INF0-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0110961; FBpp0110261; FBgn0038295 [Q8INF0-1]
FBtr0306245; FBpp0297355; FBgn0038295 [Q8INF0-1]
FBtr0334926; FBpp0306946; FBgn0038295 [Q8INF0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4154

UCSC genome browser

More...
UCSCi
CG4154-RD, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55135.5
AE014297 Genomic DNA Translation: ABI31167.1
AE014297 Genomic DNA Translation: AFH06433.1
BT029937 mRNA Translation: ABM92811.1 Frameshift.
AY376404 mRNA Translation: AAQ84038.1 Sequence problems.
AY376405 mRNA Translation: AAQ84039.1 Sequence problems.
RefSeqiNP_001036711.1, NM_001043246.4 [Q8INF0-1]
NP_001247115.1, NM_001260186.2 [Q8INF0-1]
NP_731974.4, NM_169616.4 [Q8INF0-2]

3D structure databases

SMRiQ8INF0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8INF0, 1 interactor
STRINGi7227.FBpp0110261

Proteomic databases

PaxDbiQ8INF0
PRIDEiQ8INF0

Genome annotation databases

EnsemblMetazoaiFBtr0110961; FBpp0110261; FBgn0038295 [Q8INF0-1]
FBtr0306245; FBpp0297355; FBgn0038295 [Q8INF0-1]
FBtr0334926; FBpp0306946; FBgn0038295 [Q8INF0-2]
GeneIDi41825
KEGGidme:Dmel_CG4154
UCSCiCG4154-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41825
FlyBaseiFBgn0038295, Gyc88E

Phylogenomic databases

eggNOGiKOG4171, Eukaryota
GeneTreeiENSGT00940000165461
InParanoidiQ8INF0
KOiK01769
OMAiVHEVESQ
PhylomeDBiQ8INF0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41825, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gyc88E, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41825

Protein Ontology

More...
PROi
PR:Q8INF0

Gene expression databases

BgeeiFBgn0038295, Expressed in neuron and 15 other tissues
ExpressionAtlasiQ8INF0, baseline and differential
GenevisibleiQ8INF0, DM

Family and domain databases

Gene3Di3.30.450.260, 1 hit
3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR038158, H-NOX_domain_sf
IPR011644, Heme_NO-bd
IPR011645, HNOB_dom_associated
IPR042463, HNOB_dom_associated_sf
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR029787, Nucleotide_cyclase
PfamiView protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF07700, HNOB, 1 hit
PF07701, HNOBA, 1 hit
SMARTiView protein in SMART
SM00044, CYCc, 1 hit
SUPFAMiSSF111126, SSF111126, 1 hit
SSF55073, SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCY8E_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8INF0
Secondary accession number(s): A2RVE6
, Q0KI72, Q6U839, Q6U840, Q9VFC5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 31, 2018
Last modified: August 12, 2020
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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