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Entry version 156 (08 May 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Trithorax group protein osa

Gene

osa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes. In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro. It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi. Also represses E2f activation.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-3214858 RMTs methylate histone arginines
R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trithorax group protein osa
Alternative name(s):
Protein eyelid
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:osa
Synonyms:eld
ORF Names:CG7467
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261885 osa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005931 – 2716Trithorax group protein osaAdd BLAST2716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei384Phosphothreonine1 Publication1
Modified residuei747Phosphothreonine1 Publication1
Modified residuei1930Phosphoserine1 Publication1
Modified residuei1932Phosphoserine1 Publication1
Modified residuei2081Phosphoserine1 Publication1
Modified residuei2168Phosphoserine1 Publication1
Modified residuei2169Phosphoserine1 Publication1
Modified residuei2176Phosphothreonine1 Publication1
Modified residuei2181Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IN94

PRoteomics IDEntifications database

More...
PRIDEi
Q8IN94

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IN94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in early embryo. In third instar larvae, it is ubiquitously expressed in wing and eye-antenna imaginal disks, with a stronger expression in a band just anterior to the morphogenetic furrow.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261885 Expressed in 32 organ(s), highest expression level in eye disc (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IN94 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IN94 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Brahma complex, which is composed of Brm, Osa, Mor, Snr1/Bap45, Bap111/Dalao, Bap55, Bap60 and Bap47. Interacts with Pnr and Chi via its EHD domain.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
brmP254394EBI-115993,EBI-868480

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67162, 59 interactors

Database of interacting proteins

More...
DIPi
DIP-20699N

Protein interaction database and analysis system

More...
IntActi
Q8IN94, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8IN94

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088543

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1000 – 1091ARIDPROSITE-ProRule annotationAdd BLAST92
Domaini1769 – 2517EHDAdd BLAST749

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 1763Pro-richAdd BLAST1745
Compositional biasi174 – 380Gln-richAdd BLAST207
Compositional biasi619 – 873Gly-richAdd BLAST255
Compositional biasi1222 – 1453Gly-richAdd BLAST232
Compositional biasi1271 – 1751Gln-richAdd BLAST481
Compositional biasi1730 – 1745His-richAdd BLAST16
Compositional biasi2589 – 2624Ser-richAdd BLAST36
Compositional biasi2625 – 2716Ala-richAdd BLAST92

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ARID domains mediates the binding to DNA.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2510 Eukaryota
ENOG410Y034 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169092

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IN94

KEGG Orthology (KO)

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KOi
K11653

Identification of Orthologs from Complete Genome Data

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OMAi
MAFSGKD

Database of Orthologous Groups

More...
OrthoDBi
256110at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IN94

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C

The PANTHER Classification System

More...
PANTHERi
PTHR12656 PTHR12656, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IN94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEKIKSPQT QQQQQGGAPA PAATPPSAGA APGAATPPTS GPPTPNNNSN
60 70 80 90 100
NGSDPSIQQQ QQNVAPHPYG APPPPGSGPG GPPGPDPAAV MHYHHLHQQQ
110 120 130 140 150
QQHPPPPHMQ QQQHHGGPAP PPPGGAPEHA PGVKEEYTHL PPPHPHPAYG
160 170 180 190 200
RYHADPNMDP YRYGQPLPGG KPPQQQQPHP QQQPPQQPGP GGSPNRPPQQ
210 220 230 240 250
RYIPGQPPQG PTPTLNSLLQ SSNPPPPPQH RYANTYDPQQ AAASAAAAAA
260 270 280 290 300
AQQQQAGGPP PPGHGPPPPQ HQPSPYGGQQ GGWAPPPRPY SPQLGPSQQY
310 320 330 340 350
RTPPPTNTSR GQSPYPPAHG QNSGSYPSSP QQQQQQQQQQ QQQAGQQPGG
360 370 380 390 400
PVPGGPPPGT GQQPPQQNTP PTSQYSPYPQ RYPTPPGLPA GGSNHRTAYS
410 420 430 440 450
THQYPEPNRP WPGGSSPSPG SGHPLPPASP HHVPPLQQQP PPPPHVSAGG
460 470 480 490 500
PPPSSSPGHA PSPSPQPSQA SPSPHQELIG QNSNDSSSGG AHSGMGSGPP
510 520 530 540 550
GTPNPQQVMR PTPSPTGSSG SRSMSPAVAQ NHPISRPASN QSSSGGPMQQ
560 570 580 590 600
PPVGAGGPPP MPPHPGMPGG PPQQQQSQQQ QASNSASSAS NSPQQTPPPA
610 620 630 640 650
PPPNQGMNNM ATPPPPPQGA AGGGYPMPPH MHGGYKMGGP GQSPGAQGYP
660 670 680 690 700
PQQPQQYPPG NYPPRPQYPP GAYATGPPPP PTSQAGAGGA NSMPSGAQAG
710 720 730 740 750
GYPGRGMPNH TGQYPPYQWV PPSPQQTVPG GAPGGAMVGN HVQGKGTPPP
760 770 780 790 800
PVVGGPPPPQ GSGSPRPLNY LKQHLQHKGG YGGSPTPPQG PQGYGNGPTG
810 820 830 840 850
MHPGMPMGPP HHMGPPHGPT NMGPPTSTPP QSQMLQGGQP QGQGASGGPE
860 870 880 890 900
SGGPEHISQD NGISSSGPTG AAGMHAVTSV VTTGPDGTSM DEVSQQSTLS
910 920 930 940 950
NASAASGEDP QCTTPKSRKN DPYSQSHLAP PSTSPHPVVM HPGGGPGEEY
960 970 980 990 1000
DMSSPPNWPR PAGSPQVFNH VPVPQEPFRS TITTTKKSDS LCKLYEMDDN
1010 1020 1030 1040 1050
PDRRGWLDKL RAFMEERRTP ITACPTISKQ PLDLYRLYIY VKERGGFVEV
1060 1070 1080 1090 1100
TKSKTWKDIA GLLGIGASSS AAYTLRKHYT KNLLTFECHF DRGDIDPLPI
1110 1120 1130 1140 1150
IQQVEAGSKK KTAKAASVPS PGGGHLDAGT TNSTGSSNSQ DSFPAPPGSA
1160 1170 1180 1190 1200
PNAAIDGYPG YPGGSPYPVA SGPQPDYATA GQMQRPPSQN NPQTPHPGAA
1210 1220 1230 1240 1250
AAVAAGDNIS VSNPFEDPIA AGGGPGSGTG PGPGQGPGPG AASGGAGAVG
1260 1270 1280 1290 1300
AVGGGPQPHP PPPHSPHTAA QQAAGQHQQQ HPQHQHPGLP GPPPPQQQQG
1310 1320 1330 1340 1350
QQGQQPPPSV GGGPPPAPQQ HGPGQVPPSP QQHVRPAAGA PYPPGGSGYP
1360 1370 1380 1390 1400
TPVSRTPGSP YPSQPGAYGQ YGSSDQYNAT GPPGQPFGQG PGQYPPQNRN
1410 1420 1430 1440 1450
MYPPYGPEGE APPTGANQYG PYGSRPYSQP PPGGPQPPTQ TVAGGPPAGG
1460 1470 1480 1490 1500
APGAPPSSAY PTGRPSQQDY YQPPPDQSPQ PRRHPDFIKD SQPYPGYNAR
1510 1520 1530 1540 1550
PQIYGAWQSG TQQYRPQYPS SPAPQNWGGA PPRGAAPPPG APHGPPIQQP
1560 1570 1580 1590 1600
AGVAQWDQHR YPPQQGPPPP PQQQQQPQQQ QQQPPYQQVA GPPGQQPPQA
1610 1620 1630 1640 1650
PPQWAQMNPG QTAQSGIAPP GSPLRPPSGP GQQNRMPGMP AQQQQSQQQG
1660 1670 1680 1690 1700
GVPQPPPQQA SHGGVPSPGL PQVGPGGMVK PPYAMPPPPS QGVGQQVGQG
1710 1720 1730 1740 1750
PPGGMMSQKP PPMPGQAMQQ QPLQQQPPSH QHPHPHQHPQ HQHPHQMPPN
1760 1770 1780 1790 1800
QTAPGGYGPP GMPGGGAQLV KKELIFPHDS VESTTPVLYR RKRLMKADVC
1810 1820 1830 1840 1850
PVDPWRIFMA MRSGLLTECT WALDVLNVLL FDDSTVQFFG ISNLPGLLTL
1860 1870 1880 1890 1900
LLEHFQKNLA EMFDERENEE QSALLAEDAD DDADSGTVMC EKLRTSGRQP
1910 1920 1930 1940 1950
RCVRSISSYN RRRHYENMDR SGKDGAGNGS DSEDADEGID LGQVRVQPNP
1960 1970 1980 1990 2000
EERSLLLSFT PNYTMVTRKG VPVRIQPAEN DIFVDERQKA WDIDTNRLYE
2010 2020 2030 2040 2050
QLEPVGSDAW TYGFTEPDPL DGIIDVFKSE IVNIPFARYI RSDKKGRKRT
2060 2070 2080 2090 2100
ELASSSRKPE IKTEENSTEE QTFNKKRRLV SGGSSSSGAH AEGKKSKLTS
2110 2120 2130 2140 2150
EEFAQPNAEV KKEPGTADSD CRPVDMDIEA PQQRLTNGVA PCSSTPAIFD
2160 2170 2180 2190 2200
PRTTAKDEAR VLQRRRDSSF EDECYTRDEA SLHLVSESQD SLARRCIALS
2210 2220 2230 2240 2250
NIFRNLTFVP GNETVLAKST RFLAVLGRLL LLNHEHLRRT PKTRNYDREE
2260 2270 2280 2290 2300
DTDFSDSCSS LQGEREWWWD YLITIRENML VAMANIAGHL ELSRYDELIA
2310 2320 2330 2340 2350
RPLIDGLLHW AVCPSAHGQD PFPSCGPNSV LSPQRLALEA LCKLCVTDAN
2360 2370 2380 2390 2400
VDLVIATPPF SRLEKLCAVL TRHLCRNEDQ VLREFSVNLL HYLAAADSAM
2410 2420 2430 2440 2450
ARTVALQSPC ISYLVAFIEQ AEQTALGVAN QHGINYLREN PDSMGTSLDM
2460 2470 2480 2490 2500
LRRAAGTLLH LAKHPDNRSL FMQQEQRLLG LVMSHILDQQ VALIISRVLY
2510 2520 2530 2540 2550
QVSRGTGPIH SVEFRLLQQR QQQQLRPGPA GKQAASAGGS ATVKAETAST
2560 2570 2580 2590 2600
ETSSTEAKPA PAATTAVVND ENSNSSQQLP PAATFNDVSN SSTNSNSCGT
2610 2620 2630 2640 2650
ASSNQTNNST TNSSHSSSAI SSQSAITVAA PSAAATGAGS ATAAAIASDQ
2660 2670 2680 2690 2700
QQVSKVAAAA AAAAALSNAS AAAAAAAAAA AASVGPPTSS SVSAGAAVAQ
2710
PAAPPPTNAG TTTAVA
Length:2,716
Mass (Da):284,064
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFAE76CB51C7C675
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JIN6E1JIN6_DROME
Osa, isoform D
osa 4H, anon-WO0118547.314, anon-WO0172774.126, C819, Dmel\CG7467
2,716Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KSE8Q7KSE8_DROME
Osa, isoform C
osa 4H, anon-WO0118547.314, anon-WO0172774.126, C819, Dmel\CG7467
2,556Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGD1A0A0B4KGD1_DROME
Osa, isoform F
osa 4H, anon-WO0118547.314, anon-WO0172774.126, C819, Dmel\CG7467
2,559Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHB1A0A0B4KHB1_DROME
Osa, isoform E
osa 4H, anon-WO0118547.314, anon-WO0172774.126, C819, Dmel\CG7467
2,555Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF55457 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61Missing in AAC06254 (PubMed:9271118).Curated1
Sequence conflicti1169V → G in AAC06254 (PubMed:9271118).Curated1
Sequence conflicti1795M → T in AAC06254 (PubMed:9271118).Curated1
Sequence conflicti2637G → E in AAC06254 (PubMed:9271118).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF053091 mRNA Translation: AAC06254.1
AE014297 Genomic DNA Translation: AAF55457.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN13750.1

Protein sequence database of the Protein Information Resource

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PIRi
T13049

NCBI Reference Sequences

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RefSeqi
NP_001163639.1, NM_001170168.2
NP_524392.2, NM_079668.3
NP_732263.1, NM_169775.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089581; FBpp0088543; FBgn0261885
FBtr0301487; FBpp0290702; FBgn0261885

Database of genes from NCBI RefSeq genomes

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GeneIDi
42130

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG7467

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053091 mRNA Translation: AAC06254.1
AE014297 Genomic DNA Translation: AAF55457.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN13750.1
PIRiT13049
RefSeqiNP_001163639.1, NM_001170168.2
NP_524392.2, NM_079668.3
NP_732263.1, NM_169775.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi67162, 59 interactors
DIPiDIP-20699N
IntActiQ8IN94, 6 interactors
MINTiQ8IN94
STRINGi7227.FBpp0088543

PTM databases

iPTMnetiQ8IN94

Proteomic databases

PaxDbiQ8IN94
PRIDEiQ8IN94

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089581; FBpp0088543; FBgn0261885
FBtr0301487; FBpp0290702; FBgn0261885
GeneIDi42130
KEGGidme:Dmel_CG7467

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
42130
FlyBaseiFBgn0261885 osa

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00940000169092
InParanoidiQ8IN94
KOiK11653
OMAiMAFSGKD
OrthoDBi256110at2759
PhylomeDBiQ8IN94

Enzyme and pathway databases

ReactomeiR-DME-3214858 RMTs methylate histone arginines
R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
osa fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42130

Protein Ontology

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PROi
PR:Q8IN94

Gene expression databases

BgeeiFBgn0261885 Expressed in 32 organ(s), highest expression level in eye disc (Drosophila)
ExpressionAtlasiQ8IN94 differential
GenevisibleiQ8IN94 DM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
PANTHERiPTHR12656 PTHR12656, 2 hits
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSA_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IN94
Secondary accession number(s): O61603, Q9VEG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: May 8, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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