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Protein

Sex determination protein fruitless

Gene

fru

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri918 – 941C2H2-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sex determination protein fruitless
Gene namesi
Name:fru
Synonyms:BTB-VI
ORF Names:CG14307
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004652 fru

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant males exhibit bisexual behavior; they court females but are behaviorally sterile so fail to mate and they exhibit vigorous courtship with other fru mutant males.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469211 – 955Sex determination protein fruitlessAdd BLAST955

Proteomic databases

PaxDbiQ8IN81
PeptideAtlasiQ8IN81
PRIDEiQ8IN81

Expressioni

Tissue specificityi

Expressed in parts of the adult male brain associated with the courtship song and steps of the male courtship. Also expressed in the larval and pupal male mushroom body and optic lobe. Expressed in pupal female optic lobe.3 Publications

Gene expression databases

BgeeiFBgn0004652 Expressed in 27 organ(s), highest expression level in head
ExpressionAtlasiQ8IN81 differential
GenevisibleiQ8IN81 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
bonQ9VDK54EBI-6171802,EBI-3406250

Protein-protein interaction databases

BioGridi67237, 31 interactors
DIPiDIP-17120N
IntActiQ8IN81, 6 interactors
STRINGi7227.FBpp0290499

Structurei

3D structure databases

ProteinModelPortaliQ8IN81
SMRiQ8IN81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 196BTBPROSITE-ProRule annotationCuratedAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 56His-richAdd BLAST23
Compositional biasi77 – 93Pro-richAdd BLAST17
Compositional biasi292 – 357Ala-richAdd BLAST66
Compositional biasi386 – 426Asn-richAdd BLAST41
Compositional biasi799 – 870Ala/Ser-richAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri918 – 941C2H2-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXAR Eukaryota
ENOG4111JXS LUCA
GeneTreeiENSGT00530000064321
InParanoidiQ8IN81
OrthoDBiEOG091G09E3

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (13+)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Sex specific splicing is controlled by tra and tra-2. Sex-specific repression of the translation of fru mRNA might be mediated by the binding of Tra to the fru mRNA in females.2 Publications

This entry has 13 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Male-A1 Publication (identifier: Q8IN81-1) [UniParc]FASTAAdd to basket
Also known as: E1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMATSQDYFG NPYALFRGPP TTLRPRESPL GVGHPHGHGH LHSHAHAHGH
60 70 80 90 100
GHAHSHYAAL DLQTPHKRNI ETDVRAPPPP LPPPPLPLPP ASPRYNTDQG
110 120 130 140 150
AMDQQFCLRW NNHPTNLTGV LTSLLQREAL CDVTLACEGE TVKAHQTILS
160 170 180 190 200
ACSPYFETIF LQNQHPHPII YLKDVRYSEM RSLLDFMYKG EVNVGQSSLP
210 220 230 240 250
MFLKTAESLQ VRGLTDNNNL NYRSDCDKLR DSAASSPTGR GPSNYTGGLG
260 270 280 290 300
GAGGVADAMR ESRDSLRSRC ERDLRDELTQ RSSSSMSERS SAAAAAAAAA
310 320 330 340 350
AAVAAAGGNV NAAAVALGLT TPTGGERSPS VGSASAAAAA AAVAAAVAAA
360 370 380 390 400
ANRSASADGC SDRGSERGTL ERTDSRDDLL QLDYSNKDNN NSNSSSTGGN
410 420 430 440 450
NNNNNNNNNN SSSNNNNSSS NRERNNSGER ERERERERER DRDRELSTTP
460 470 480 490 500
VEQLSSSKRR RKNSSSNCDN SLSSSHQDRH YPQDSQANFK SSPVPKTGGS
510 520 530 540 550
TSESEDAGGR HDSPLSMTTS VHLGGGGGNV GAASALSGLS QSLSIKQELM
560 570 580 590 600
DAQQQQQHRE HHVALPPDYL PSAALKLHAE DMSTLLTQHA LQAADARDEH
610 620 630 640 650
NDAKQLQLDQ TDNIDGRVKC FNIKHDRHPD RELDRNHREH DDDPGVIEEV
660 670 680 690 700
VVDHVREMEA GNEHDPEEMK EAAYHATPPK YRRAVVYAPP HPDEEAASGS
710 720 730 740 750
GSDIYVDGGY NCEYKCKELN MRAIRCSRQQ HMMSHYSPHH PHHRSLIDCP
760 770 780 790 800
AEAAYSPPVA NNQAYLASNG AVQQLDLSTY HGHANHQLHQ HPPSATHPSH
810 820 830 840 850
SQSSPHYPSA SGAGAGAGSV SVSIAGSASG SATSAPASVA TSAVSPQPSS
860 870 880 890 900
SSTGSTSSAA AVAAAAAAAA NRRDHNIDYS TLFVQLSGTL PTLYRCVSCN
910 920 930 940 950
KIVSNRWHHA NIHRPQSHEC PVCGQKFTRR DNMKAHCKIK HADIKDRFFS

HYVHM
Length:955
Mass (Da):102,880
Last modified:March 1, 2003 - v1
Checksum:iE2A6005D5A7FB7B7
GO
Isoform Female-A1 Publication (identifier: Q8IN81-4) [UniParc]FASTAAdd to basket
Also known as: C1 Publication, L, M

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:854
Mass (Da):91,936
Checksum:i3586E2B2CD274996
GO
Isoform Female-B1 Publication (identifier: Q8IN81-7) [UniParc]FASTAAdd to basket
Also known as: F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:688
Mass (Da):73,094
Checksum:i66338CF48C6BF42C
GO
Isoform Female-E1 Publication (identifier: Q8IN81-10) [UniParc]FASTAAdd to basket
Also known as: H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.

Show »
Length:695
Mass (Da):75,537
Checksum:i28B9F9BD279B2DB1
GO
Isoform Female-I1 Publication (identifier: Q8IN81-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     324-336: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:675
Mass (Da):71,950
Checksum:iE4772F505C0B0577
GO
Isoform Male-B1 Publication (identifier: Q8IN81-6) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:789
Mass (Da):84,038
Checksum:i7F87220F6C723A29
GO
Isoform Male-E1 Publication (identifier: Q8IN81-12) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.

Show »
Length:796
Mass (Da):86,481
Checksum:iDB9F4F6F30170AD8
GO
Isoform Male-I1 Publication (identifier: Q8IN81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-336: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:776
Mass (Da):82,895
Checksum:iBE4560B1E0DF6297
GO
Isoform Type-C1 Publication (identifier: Q8IN81-8) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     572-766: SAALKLHAED...PPVANNQAYL → VKKSEAFLGS...ITINVGKNSA
     767-955: Missing.

Show »
Length:665
Mass (Da):72,365
Checksum:i2235D16063D4444C
GO
Isoform Type-D1 Publication (identifier: Q8IN81-9) [UniParc]FASTAAdd to basket
Also known as: A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-617: R → E
     618-955: Missing.

Show »
Length:516
Mass (Da):55,086
Checksum:iE91B5D22099FF65B
GO
Isoform I (identifier: Q8IN81-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-94: LPLPPASPR → MLQKNSVRK

Note: No experimental confirmation available.
Show »
Length:870
Mass (Da):93,771
Checksum:i4F1911F85760770A
GO
Isoform J (identifier: Q8IN81-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-51: Missing.
     52-94: HAHSHYAALD...PLPLPPASPR → SRISRNIDSA...RPPLDALPLW

Show »
Length:906
Mass (Da):97,595
Checksum:iA740B79FB6699DB6
GO
Isoform K (identifier: Q8IN81-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
     92-93: SP → MT
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):76,675
Checksum:iF2D99E279741D9EE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KG97A0A0B4KG97_DROME
Fruitless, isoform O
fru BTB-VI, BtbVI, CG33541, CG7688, cg7688
882Annotation score:
E1JIP5E1JIP5_DROME
Fruitless, isoform N
fru BTB-VI, BtbVI, CG33541, CG7688, cg7688
960Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93P → PSLQIS in ABC86512 (Ref. 6) Curated1
Sequence conflicti107C → S in AAA50838 (PubMed:7938017).Curated1
Sequence conflicti131C → R in BAA12664 (PubMed:10934470).Curated1
Sequence conflicti212 – 218RGLTDNN → CANQGSI in AAA50838 (PubMed:7938017).Curated7
Sequence conflicti722 – 723RA → QRN in AAB92662 (PubMed:8790392).Curated2
Sequence conflicti722 – 723RA → QRN in BAA12663 (PubMed:10934470).Curated2
Sequence conflicti722 – 723RA → QRN in BAA12664 (PubMed:10934470).Curated2
Isoform Type-C1 Publication (identifier: Q8IN81-8)
Sequence conflicti539S → P in AAG28590 (PubMed:10934470).Curated1
Sequence conflicti617H → R in AAG28590 (PubMed:10934470).Curated1
Isoform Female-B1 Publication (identifier: Q8IN81-7)
Sequence conflicti650T → A in AAG28589 (PubMed:10934470).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0504971 – 101Missing in isoform Female-I, isoform Female-A, isoform Type-D, isoform Type-C, isoform Female-B and isoform Female-E. 3 PublicationsAdd BLAST101
Alternative sequenceiVSP_0393961 – 91Missing in isoform K. CuratedAdd BLAST91
Alternative sequenceiVSP_0393971 – 85Missing in isoform I. CuratedAdd BLAST85
Alternative sequenceiVSP_0393983 – 51Missing in isoform J. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_03939952 – 94HAHSH…PASPR → SRISRNIDSASCLACPTCIT CPTGPAFPICHIRRPPLDAL PLW in isoform J. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_03940086 – 94LPLPPASPR → MLQKNSVRK in isoform I. Curated9
Alternative sequenceiVSP_03940192 – 93SP → MT in isoform K. Curated2
Alternative sequenceiVSP_050498324 – 336Missing in isoform Female-I and isoform Male-I. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_050499572 – 766SAALK…NQAYL → VKKSEAFLGSTGNKSMHQML LHQAVEAQLKSFQLHYQNEG LDSAMHRLLAQQQQHQEQQQ QHQQQPHHSLGKSQSPAIPS GSAGGSSRKSGRFRANWLYQ FEWLQYDERANTMFCRHCRK WSGELADIRTSFVEGNSNFR LEIVNHHNKCKSHRMCYERE LQEQQQHPMPSGSAGGSSKR RSPEIITINVGKNSA in isoform Type-C. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_050500617 – 796RVKCF…PPSAT → SKAWHMRLTFERLSGGCNLH RCKLCGKVVTHIRNHYHVHF PGRFECPLCRATYTRSDNLR THCKFKHPMYNPDTRKFDNL MSSSAVGAAATPTASQLAVA SQAAMAAAAAAAFNAAQQQQ QQQQQQQQHQHQQQQQHQQS QQQQQQQQQSQQQLHALAQQ HMLQLQPQHHQQQQHNATSE in isoform Female-E, isoform K and isoform Male-E. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_050501617 – 789RVKCF…NHQLH → SSARHHLSTPLSTSSSASPP PPPFGMHLSAALKREYHPLH YMAAGNGHNGPSALGYGNQG SGNAPNSAGGAGSVAGGVGA GGGAGGATGAAGHNSHHTMS YHNMFTPSRDPGTMWRCRSC GKEVTNRWHHFHSHTAQRSM CPYCPATYSRIDTLRSHLRV KHPDRLLKLNSSI in isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B. 2 PublicationsAdd BLAST173
Alternative sequenceiVSP_050502617R → E in isoform Type-D. 1 Publication1
Alternative sequenceiVSP_050503618 – 955Missing in isoform Type-D. 1 PublicationAdd BLAST338
Alternative sequenceiVSP_050504767 – 955Missing in isoform Type-C. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_050505790 – 955Missing in isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B. 2 PublicationsAdd BLAST166
Alternative sequenceiVSP_050506797 – 955Missing in isoform Female-E, isoform K and isoform Male-E. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039231 mRNA Translation: AAB96677.1
U72492 mRNA Translation: AAB92662.1
D84437 mRNA Translation: BAA12663.1
D84438 mRNA Translation: BAA12664.1
AF220176 mRNA Translation: AAG28587.1
AF220177 mRNA Translation: AAG28588.1
AF220178 mRNA Translation: AAG28589.1
AF220179 mRNA Translation: AAG28590.1
AF220180 mRNA Translation: AAG28591.1
AF220181 mRNA Translation: AAG28592.1
AE014297 Genomic DNA Translation: AAF55562.2
AE014297 Genomic DNA Translation: AAF55563.2
AE014297 Genomic DNA Translation: AAF55564.2
AE014297 Genomic DNA Translation: AAF55565.2
AE014297 Genomic DNA Translation: AAN13774.1
AE014297 Genomic DNA Translation: AAN13775.1
AE014297 Genomic DNA Translation: AAN13776.1
AE014297 Genomic DNA Translation: AAN13777.1
AE014297 Genomic DNA Translation: AAS65172.1
AE014297 Genomic DNA Translation: AAS65173.1
AE014297 Genomic DNA Translation: AAS65174.1
AE014297 Genomic DNA Translation: AAS65175.1
AE014297 Genomic DNA Translation: AAS65176.1
BT024450 mRNA Translation: ABC86512.1
AY152837 mRNA Translation: AAN74532.1
AY152838 mRNA Translation: AAN74533.1
U14403 Genomic DNA Translation: AAA50838.1
RefSeqiNP_001163648.1, NM_001170177.2
NP_524397.2, NM_079673.3 [Q8IN81-7]
NP_732344.1, NM_169816.2 [Q8IN81-6]
NP_732345.1, NM_169817.2 [Q8IN81-12]
NP_732346.1, NM_169818.2 [Q8IN81-10]
NP_732347.1, NM_169819.2 [Q8IN81-1]
NP_732348.1, NM_169820.2 [Q8IN81-4]
NP_732349.1, NM_169821.2 [Q8IN81-9]
NP_732350.1, NM_169822.2 [Q8IN81-8]
NP_996234.1, NM_206512.2 [Q8IN81-4]
NP_996235.1, NM_206513.2 [Q8IN81-4]
NP_996236.1, NM_206514.2 [Q8IN81-15]
NP_996237.1, NM_206515.2 [Q8IN81-14]
NP_996238.1, NM_206516.2 [Q8IN81-13]
UniGeneiDm.4626

Genome annotation databases

EnsemblMetazoaiFBtr0083640; FBpp0083060; FBgn0004652 [Q8IN81-10]
FBtr0083641; FBpp0083061; FBgn0004652 [Q8IN81-6]
FBtr0083642; FBpp0083062; FBgn0004652 [Q8IN81-4]
FBtr0083643; FBpp0083063; FBgn0004652 [Q8IN81-1]
FBtr0083644; FBpp0083064; FBgn0004652 [Q8IN81-7]
FBtr0083645; FBpp0083065; FBgn0004652 [Q8IN81-12]
FBtr0083646; FBpp0083066; FBgn0004652 [Q8IN81-9]
FBtr0083647; FBpp0083067; FBgn0004652 [Q8IN81-8]
FBtr0083648; FBpp0089355; FBgn0004652 [Q8IN81-13]
FBtr0083649; FBpp0089356; FBgn0004652 [Q8IN81-14]
FBtr0083650; FBpp0089357; FBgn0004652 [Q8IN81-15]
FBtr0083651; FBpp0089358; FBgn0004652 [Q8IN81-4]
FBtr0083652; FBpp0089359; FBgn0004652 [Q8IN81-4]
GeneIDi42226
KEGGidme:Dmel_CG14307
UCSCiCG14307-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039231 mRNA Translation: AAB96677.1
U72492 mRNA Translation: AAB92662.1
D84437 mRNA Translation: BAA12663.1
D84438 mRNA Translation: BAA12664.1
AF220176 mRNA Translation: AAG28587.1
AF220177 mRNA Translation: AAG28588.1
AF220178 mRNA Translation: AAG28589.1
AF220179 mRNA Translation: AAG28590.1
AF220180 mRNA Translation: AAG28591.1
AF220181 mRNA Translation: AAG28592.1
AE014297 Genomic DNA Translation: AAF55562.2
AE014297 Genomic DNA Translation: AAF55563.2
AE014297 Genomic DNA Translation: AAF55564.2
AE014297 Genomic DNA Translation: AAF55565.2
AE014297 Genomic DNA Translation: AAN13774.1
AE014297 Genomic DNA Translation: AAN13775.1
AE014297 Genomic DNA Translation: AAN13776.1
AE014297 Genomic DNA Translation: AAN13777.1
AE014297 Genomic DNA Translation: AAS65172.1
AE014297 Genomic DNA Translation: AAS65173.1
AE014297 Genomic DNA Translation: AAS65174.1
AE014297 Genomic DNA Translation: AAS65175.1
AE014297 Genomic DNA Translation: AAS65176.1
BT024450 mRNA Translation: ABC86512.1
AY152837 mRNA Translation: AAN74532.1
AY152838 mRNA Translation: AAN74533.1
U14403 Genomic DNA Translation: AAA50838.1
RefSeqiNP_001163648.1, NM_001170177.2
NP_524397.2, NM_079673.3 [Q8IN81-7]
NP_732344.1, NM_169816.2 [Q8IN81-6]
NP_732345.1, NM_169817.2 [Q8IN81-12]
NP_732346.1, NM_169818.2 [Q8IN81-10]
NP_732347.1, NM_169819.2 [Q8IN81-1]
NP_732348.1, NM_169820.2 [Q8IN81-4]
NP_732349.1, NM_169821.2 [Q8IN81-9]
NP_732350.1, NM_169822.2 [Q8IN81-8]
NP_996234.1, NM_206512.2 [Q8IN81-4]
NP_996235.1, NM_206513.2 [Q8IN81-4]
NP_996236.1, NM_206514.2 [Q8IN81-15]
NP_996237.1, NM_206515.2 [Q8IN81-14]
NP_996238.1, NM_206516.2 [Q8IN81-13]
UniGeneiDm.4626

3D structure databases

ProteinModelPortaliQ8IN81
SMRiQ8IN81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67237, 31 interactors
DIPiDIP-17120N
IntActiQ8IN81, 6 interactors
STRINGi7227.FBpp0290499

Proteomic databases

PaxDbiQ8IN81
PeptideAtlasiQ8IN81
PRIDEiQ8IN81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083640; FBpp0083060; FBgn0004652 [Q8IN81-10]
FBtr0083641; FBpp0083061; FBgn0004652 [Q8IN81-6]
FBtr0083642; FBpp0083062; FBgn0004652 [Q8IN81-4]
FBtr0083643; FBpp0083063; FBgn0004652 [Q8IN81-1]
FBtr0083644; FBpp0083064; FBgn0004652 [Q8IN81-7]
FBtr0083645; FBpp0083065; FBgn0004652 [Q8IN81-12]
FBtr0083646; FBpp0083066; FBgn0004652 [Q8IN81-9]
FBtr0083647; FBpp0083067; FBgn0004652 [Q8IN81-8]
FBtr0083648; FBpp0089355; FBgn0004652 [Q8IN81-13]
FBtr0083649; FBpp0089356; FBgn0004652 [Q8IN81-14]
FBtr0083650; FBpp0089357; FBgn0004652 [Q8IN81-15]
FBtr0083651; FBpp0089358; FBgn0004652 [Q8IN81-4]
FBtr0083652; FBpp0089359; FBgn0004652 [Q8IN81-4]
GeneIDi42226
KEGGidme:Dmel_CG14307
UCSCiCG14307-RA d. melanogaster

Organism-specific databases

CTDi42226
FlyBaseiFBgn0004652 fru

Phylogenomic databases

eggNOGiENOG410IXAR Eukaryota
ENOG4111JXS LUCA
GeneTreeiENSGT00530000064321
InParanoidiQ8IN81
OrthoDBiEOG091G09E3

Miscellaneous databases

GenomeRNAii42226
PROiPR:Q8IN81

Gene expression databases

BgeeiFBgn0004652 Expressed in 27 organ(s), highest expression level in head
ExpressionAtlasiQ8IN81 differential
GenevisibleiQ8IN81 DM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRU_DROME
AccessioniPrimary (citable) accession number: Q8IN81
Secondary accession number(s): A4V334
, O44708, P91618, P91619, Q24004, Q29QE0, Q7KSD2, Q7KSD5, Q7KSD6, Q8IN80, Q8IN82, Q8IN83, Q8IS35, Q8IS36, Q9GU18, Q9GU19, Q9GU20, Q9GU21, Q9GU22, Q9VE64, Q9VE65, Q9VE66, Q9VE67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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