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Protein

Sex determination protein fruitless

Gene

fru

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri918 – 941C2H2-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sex determination protein fruitless
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fru
Synonyms:BTB-VI
ORF Names:CG14307
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004652 fru

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant males exhibit bisexual behavior; they court females but are behaviorally sterile so fail to mate and they exhibit vigorous courtship with other fru mutant males.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000469211 – 955Sex determination protein fruitlessAdd BLAST955

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IN81

PeptideAtlas

More...
PeptideAtlasi
Q8IN81

PRoteomics IDEntifications database

More...
PRIDEi
Q8IN81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in parts of the adult male brain associated with the courtship song and steps of the male courtship. Also expressed in the larval and pupal male mushroom body and optic lobe. Expressed in pupal female optic lobe.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004652 Expressed in 27 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IN81 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IN81 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
bonQ9VDK54EBI-6171802,EBI-3406250

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67237, 35 interactors

Database of interacting proteins

More...
DIPi
DIP-17120N

Protein interaction database and analysis system

More...
IntActi
Q8IN81, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290499

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IN81

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IN81

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 196BTBPROSITE-ProRule annotationCuratedAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 56His-richAdd BLAST23
Compositional biasi77 – 93Pro-richAdd BLAST17
Compositional biasi292 – 357Ala-richAdd BLAST66
Compositional biasi386 – 426Asn-richAdd BLAST41
Compositional biasi799 – 870Ala/Ser-richAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri918 – 941C2H2-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXAR Eukaryota
ENOG4111JXS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064321

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IN81

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 13 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Sex specific splicing is controlled by tra and tra-2. Sex-specific repression of the translation of fru mRNA might be mediated by the binding of Tra to the fru mRNA in females.2 Publications

This entry has 13 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Male-A1 Publication (identifier: Q8IN81-1) [UniParc]FASTAAdd to basket
Also known as: E1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMATSQDYFG NPYALFRGPP TTLRPRESPL GVGHPHGHGH LHSHAHAHGH
60 70 80 90 100
GHAHSHYAAL DLQTPHKRNI ETDVRAPPPP LPPPPLPLPP ASPRYNTDQG
110 120 130 140 150
AMDQQFCLRW NNHPTNLTGV LTSLLQREAL CDVTLACEGE TVKAHQTILS
160 170 180 190 200
ACSPYFETIF LQNQHPHPII YLKDVRYSEM RSLLDFMYKG EVNVGQSSLP
210 220 230 240 250
MFLKTAESLQ VRGLTDNNNL NYRSDCDKLR DSAASSPTGR GPSNYTGGLG
260 270 280 290 300
GAGGVADAMR ESRDSLRSRC ERDLRDELTQ RSSSSMSERS SAAAAAAAAA
310 320 330 340 350
AAVAAAGGNV NAAAVALGLT TPTGGERSPS VGSASAAAAA AAVAAAVAAA
360 370 380 390 400
ANRSASADGC SDRGSERGTL ERTDSRDDLL QLDYSNKDNN NSNSSSTGGN
410 420 430 440 450
NNNNNNNNNN SSSNNNNSSS NRERNNSGER ERERERERER DRDRELSTTP
460 470 480 490 500
VEQLSSSKRR RKNSSSNCDN SLSSSHQDRH YPQDSQANFK SSPVPKTGGS
510 520 530 540 550
TSESEDAGGR HDSPLSMTTS VHLGGGGGNV GAASALSGLS QSLSIKQELM
560 570 580 590 600
DAQQQQQHRE HHVALPPDYL PSAALKLHAE DMSTLLTQHA LQAADARDEH
610 620 630 640 650
NDAKQLQLDQ TDNIDGRVKC FNIKHDRHPD RELDRNHREH DDDPGVIEEV
660 670 680 690 700
VVDHVREMEA GNEHDPEEMK EAAYHATPPK YRRAVVYAPP HPDEEAASGS
710 720 730 740 750
GSDIYVDGGY NCEYKCKELN MRAIRCSRQQ HMMSHYSPHH PHHRSLIDCP
760 770 780 790 800
AEAAYSPPVA NNQAYLASNG AVQQLDLSTY HGHANHQLHQ HPPSATHPSH
810 820 830 840 850
SQSSPHYPSA SGAGAGAGSV SVSIAGSASG SATSAPASVA TSAVSPQPSS
860 870 880 890 900
SSTGSTSSAA AVAAAAAAAA NRRDHNIDYS TLFVQLSGTL PTLYRCVSCN
910 920 930 940 950
KIVSNRWHHA NIHRPQSHEC PVCGQKFTRR DNMKAHCKIK HADIKDRFFS

HYVHM
Length:955
Mass (Da):102,880
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2A6005D5A7FB7B7
GO
Isoform Female-A1 Publication (identifier: Q8IN81-4) [UniParc]FASTAAdd to basket
Also known as: C1 Publication, L, M

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:854
Mass (Da):91,936
Checksum:i3586E2B2CD274996
GO
Isoform Female-B1 Publication (identifier: Q8IN81-7) [UniParc]FASTAAdd to basket
Also known as: F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:688
Mass (Da):73,094
Checksum:i66338CF48C6BF42C
GO
Isoform Female-E1 Publication (identifier: Q8IN81-10) [UniParc]FASTAAdd to basket
Also known as: H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.

Show »
Length:695
Mass (Da):75,537
Checksum:i28B9F9BD279B2DB1
GO
Isoform Female-I1 Publication (identifier: Q8IN81-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     324-336: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:675
Mass (Da):71,950
Checksum:iE4772F505C0B0577
GO
Isoform Male-B1 Publication (identifier: Q8IN81-6) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:789
Mass (Da):84,038
Checksum:i7F87220F6C723A29
GO
Isoform Male-E1 Publication (identifier: Q8IN81-12) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.

Show »
Length:796
Mass (Da):86,481
Checksum:iDB9F4F6F30170AD8
GO
Isoform Male-I1 Publication (identifier: Q8IN81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-336: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Show »
Length:776
Mass (Da):82,895
Checksum:iBE4560B1E0DF6297
GO
Isoform Type-C1 Publication (identifier: Q8IN81-8) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     572-766: SAALKLHAED...PPVANNQAYL → VKKSEAFLGS...ITINVGKNSA
     767-955: Missing.

Show »
Length:665
Mass (Da):72,365
Checksum:i2235D16063D4444C
GO
Isoform Type-D1 Publication (identifier: Q8IN81-9) [UniParc]FASTAAdd to basket
Also known as: A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-617: R → E
     618-955: Missing.

Show »
Length:516
Mass (Da):55,086
Checksum:iE91B5D22099FF65B
GO
Isoform I (identifier: Q8IN81-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-94: LPLPPASPR → MLQKNSVRK

Note: No experimental confirmation available.
Show »
Length:870
Mass (Da):93,771
Checksum:i4F1911F85760770A
GO
Isoform J (identifier: Q8IN81-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-51: Missing.
     52-94: HAHSHYAALD...PLPLPPASPR → SRISRNIDSA...RPPLDALPLW

Show »
Length:906
Mass (Da):97,595
Checksum:iA740B79FB6699DB6
GO
Isoform K (identifier: Q8IN81-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
     92-93: SP → MT
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):76,675
Checksum:iF2D99E279741D9EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KG97A0A0B4KG97_DROME
Fruitless, isoform O
fru BTB-VI, BtbVI, CG33541, CG7688, cg7688
882Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JIP5E1JIP5_DROME
Fruitless, isoform N
fru BTB-VI, BtbVI, CG33541, CG7688, cg7688
960Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93P → PSLQIS in ABC86512 (Ref. 6) Curated1
Sequence conflicti107C → S in AAA50838 (PubMed:7938017).Curated1
Sequence conflicti131C → R in BAA12664 (PubMed:10934470).Curated1
Sequence conflicti212 – 218RGLTDNN → CANQGSI in AAA50838 (PubMed:7938017).Curated7
Sequence conflicti722 – 723RA → QRN in AAB92662 (PubMed:8790392).Curated2
Sequence conflicti722 – 723RA → QRN in BAA12663 (PubMed:10934470).Curated2
Sequence conflicti722 – 723RA → QRN in BAA12664 (PubMed:10934470).Curated2
Isoform Type-C1 Publication (identifier: Q8IN81-8)
Sequence conflicti539S → P in AAG28590 (PubMed:10934470).Curated1
Sequence conflicti617H → R in AAG28590 (PubMed:10934470).Curated1
Isoform Female-B1 Publication (identifier: Q8IN81-7)
Sequence conflicti650T → A in AAG28589 (PubMed:10934470).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0504971 – 101Missing in isoform Female-I, isoform Female-A, isoform Type-D, isoform Type-C, isoform Female-B and isoform Female-E. 3 PublicationsAdd BLAST101
Alternative sequenceiVSP_0393961 – 91Missing in isoform K. CuratedAdd BLAST91
Alternative sequenceiVSP_0393971 – 85Missing in isoform I. CuratedAdd BLAST85
Alternative sequenceiVSP_0393983 – 51Missing in isoform J. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_03939952 – 94HAHSH…PASPR → SRISRNIDSASCLACPTCIT CPTGPAFPICHIRRPPLDAL PLW in isoform J. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_03940086 – 94LPLPPASPR → MLQKNSVRK in isoform I. Curated9
Alternative sequenceiVSP_03940192 – 93SP → MT in isoform K. Curated2
Alternative sequenceiVSP_050498324 – 336Missing in isoform Female-I and isoform Male-I. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_050499572 – 766SAALK…NQAYL → VKKSEAFLGSTGNKSMHQML LHQAVEAQLKSFQLHYQNEG LDSAMHRLLAQQQQHQEQQQ QHQQQPHHSLGKSQSPAIPS GSAGGSSRKSGRFRANWLYQ FEWLQYDERANTMFCRHCRK WSGELADIRTSFVEGNSNFR LEIVNHHNKCKSHRMCYERE LQEQQQHPMPSGSAGGSSKR RSPEIITINVGKNSA in isoform Type-C. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_050500617 – 796RVKCF…PPSAT → SKAWHMRLTFERLSGGCNLH RCKLCGKVVTHIRNHYHVHF PGRFECPLCRATYTRSDNLR THCKFKHPMYNPDTRKFDNL MSSSAVGAAATPTASQLAVA SQAAMAAAAAAAFNAAQQQQ QQQQQQQQHQHQQQQQHQQS QQQQQQQQQSQQQLHALAQQ HMLQLQPQHHQQQQHNATSE in isoform Female-E, isoform K and isoform Male-E. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_050501617 – 789RVKCF…NHQLH → SSARHHLSTPLSTSSSASPP PPPFGMHLSAALKREYHPLH YMAAGNGHNGPSALGYGNQG SGNAPNSAGGAGSVAGGVGA GGGAGGATGAAGHNSHHTMS YHNMFTPSRDPGTMWRCRSC GKEVTNRWHHFHSHTAQRSM CPYCPATYSRIDTLRSHLRV KHPDRLLKLNSSI in isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B. 2 PublicationsAdd BLAST173
Alternative sequenceiVSP_050502617R → E in isoform Type-D. 1 Publication1
Alternative sequenceiVSP_050503618 – 955Missing in isoform Type-D. 1 PublicationAdd BLAST338
Alternative sequenceiVSP_050504767 – 955Missing in isoform Type-C. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_050505790 – 955Missing in isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B. 2 PublicationsAdd BLAST166
Alternative sequenceiVSP_050506797 – 955Missing in isoform Female-E, isoform K and isoform Male-E. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF039231 mRNA Translation: AAB96677.1
U72492 mRNA Translation: AAB92662.1
D84437 mRNA Translation: BAA12663.1
D84438 mRNA Translation: BAA12664.1
AF220176 mRNA Translation: AAG28587.1
AF220177 mRNA Translation: AAG28588.1
AF220178 mRNA Translation: AAG28589.1
AF220179 mRNA Translation: AAG28590.1
AF220180 mRNA Translation: AAG28591.1
AF220181 mRNA Translation: AAG28592.1
AE014297 Genomic DNA Translation: AAF55562.2
AE014297 Genomic DNA Translation: AAF55563.2
AE014297 Genomic DNA Translation: AAF55564.2
AE014297 Genomic DNA Translation: AAF55565.2
AE014297 Genomic DNA Translation: AAN13774.1
AE014297 Genomic DNA Translation: AAN13775.1
AE014297 Genomic DNA Translation: AAN13776.1
AE014297 Genomic DNA Translation: AAN13777.1
AE014297 Genomic DNA Translation: AAS65172.1
AE014297 Genomic DNA Translation: AAS65173.1
AE014297 Genomic DNA Translation: AAS65174.1
AE014297 Genomic DNA Translation: AAS65175.1
AE014297 Genomic DNA Translation: AAS65176.1
BT024450 mRNA Translation: ABC86512.1
AY152837 mRNA Translation: AAN74532.1
AY152838 mRNA Translation: AAN74533.1
U14403 Genomic DNA Translation: AAA50838.1

NCBI Reference Sequences

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RefSeqi
NP_001163648.1, NM_001170177.2
NP_524397.2, NM_079673.3 [Q8IN81-7]
NP_732344.1, NM_169816.2 [Q8IN81-6]
NP_732345.1, NM_169817.2 [Q8IN81-12]
NP_732346.1, NM_169818.2 [Q8IN81-10]
NP_732347.1, NM_169819.2 [Q8IN81-1]
NP_732348.1, NM_169820.2 [Q8IN81-4]
NP_732349.1, NM_169821.2 [Q8IN81-9]
NP_732350.1, NM_169822.2 [Q8IN81-8]
NP_996234.1, NM_206512.2 [Q8IN81-4]
NP_996235.1, NM_206513.2 [Q8IN81-4]
NP_996236.1, NM_206514.2 [Q8IN81-15]
NP_996237.1, NM_206515.2 [Q8IN81-14]
NP_996238.1, NM_206516.2 [Q8IN81-13]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.4626

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0083640; FBpp0083060; FBgn0004652 [Q8IN81-10]
FBtr0083641; FBpp0083061; FBgn0004652 [Q8IN81-6]
FBtr0083642; FBpp0083062; FBgn0004652 [Q8IN81-4]
FBtr0083643; FBpp0083063; FBgn0004652 [Q8IN81-1]
FBtr0083644; FBpp0083064; FBgn0004652 [Q8IN81-7]
FBtr0083645; FBpp0083065; FBgn0004652 [Q8IN81-12]
FBtr0083646; FBpp0083066; FBgn0004652 [Q8IN81-9]
FBtr0083647; FBpp0083067; FBgn0004652 [Q8IN81-8]
FBtr0083648; FBpp0089355; FBgn0004652 [Q8IN81-13]
FBtr0083649; FBpp0089356; FBgn0004652 [Q8IN81-14]
FBtr0083650; FBpp0089357; FBgn0004652 [Q8IN81-15]
FBtr0083651; FBpp0089358; FBgn0004652 [Q8IN81-4]
FBtr0083652; FBpp0089359; FBgn0004652 [Q8IN81-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
42226

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG14307

UCSC genome browser

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UCSCi
CG14307-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039231 mRNA Translation: AAB96677.1
U72492 mRNA Translation: AAB92662.1
D84437 mRNA Translation: BAA12663.1
D84438 mRNA Translation: BAA12664.1
AF220176 mRNA Translation: AAG28587.1
AF220177 mRNA Translation: AAG28588.1
AF220178 mRNA Translation: AAG28589.1
AF220179 mRNA Translation: AAG28590.1
AF220180 mRNA Translation: AAG28591.1
AF220181 mRNA Translation: AAG28592.1
AE014297 Genomic DNA Translation: AAF55562.2
AE014297 Genomic DNA Translation: AAF55563.2
AE014297 Genomic DNA Translation: AAF55564.2
AE014297 Genomic DNA Translation: AAF55565.2
AE014297 Genomic DNA Translation: AAN13774.1
AE014297 Genomic DNA Translation: AAN13775.1
AE014297 Genomic DNA Translation: AAN13776.1
AE014297 Genomic DNA Translation: AAN13777.1
AE014297 Genomic DNA Translation: AAS65172.1
AE014297 Genomic DNA Translation: AAS65173.1
AE014297 Genomic DNA Translation: AAS65174.1
AE014297 Genomic DNA Translation: AAS65175.1
AE014297 Genomic DNA Translation: AAS65176.1
BT024450 mRNA Translation: ABC86512.1
AY152837 mRNA Translation: AAN74532.1
AY152838 mRNA Translation: AAN74533.1
U14403 Genomic DNA Translation: AAA50838.1
RefSeqiNP_001163648.1, NM_001170177.2
NP_524397.2, NM_079673.3 [Q8IN81-7]
NP_732344.1, NM_169816.2 [Q8IN81-6]
NP_732345.1, NM_169817.2 [Q8IN81-12]
NP_732346.1, NM_169818.2 [Q8IN81-10]
NP_732347.1, NM_169819.2 [Q8IN81-1]
NP_732348.1, NM_169820.2 [Q8IN81-4]
NP_732349.1, NM_169821.2 [Q8IN81-9]
NP_732350.1, NM_169822.2 [Q8IN81-8]
NP_996234.1, NM_206512.2 [Q8IN81-4]
NP_996235.1, NM_206513.2 [Q8IN81-4]
NP_996236.1, NM_206514.2 [Q8IN81-15]
NP_996237.1, NM_206515.2 [Q8IN81-14]
NP_996238.1, NM_206516.2 [Q8IN81-13]
UniGeneiDm.4626

3D structure databases

ProteinModelPortaliQ8IN81
SMRiQ8IN81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67237, 35 interactors
DIPiDIP-17120N
IntActiQ8IN81, 6 interactors
STRINGi7227.FBpp0290499

Proteomic databases

PaxDbiQ8IN81
PeptideAtlasiQ8IN81
PRIDEiQ8IN81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083640; FBpp0083060; FBgn0004652 [Q8IN81-10]
FBtr0083641; FBpp0083061; FBgn0004652 [Q8IN81-6]
FBtr0083642; FBpp0083062; FBgn0004652 [Q8IN81-4]
FBtr0083643; FBpp0083063; FBgn0004652 [Q8IN81-1]
FBtr0083644; FBpp0083064; FBgn0004652 [Q8IN81-7]
FBtr0083645; FBpp0083065; FBgn0004652 [Q8IN81-12]
FBtr0083646; FBpp0083066; FBgn0004652 [Q8IN81-9]
FBtr0083647; FBpp0083067; FBgn0004652 [Q8IN81-8]
FBtr0083648; FBpp0089355; FBgn0004652 [Q8IN81-13]
FBtr0083649; FBpp0089356; FBgn0004652 [Q8IN81-14]
FBtr0083650; FBpp0089357; FBgn0004652 [Q8IN81-15]
FBtr0083651; FBpp0089358; FBgn0004652 [Q8IN81-4]
FBtr0083652; FBpp0089359; FBgn0004652 [Q8IN81-4]
GeneIDi42226
KEGGidme:Dmel_CG14307
UCSCiCG14307-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
42226
FlyBaseiFBgn0004652 fru

Phylogenomic databases

eggNOGiENOG410IXAR Eukaryota
ENOG4111JXS LUCA
GeneTreeiENSGT00530000064321
InParanoidiQ8IN81

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42226

Protein Ontology

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PROi
PR:Q8IN81

Gene expression databases

BgeeiFBgn0004652 Expressed in 27 organ(s), highest expression level in head
ExpressionAtlasiQ8IN81 differential
GenevisibleiQ8IN81 DM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRU_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IN81
Secondary accession number(s): A4V334
, O44708, P91618, P91619, Q24004, Q29QE0, Q7KSD2, Q7KSD5, Q7KSD6, Q8IN80, Q8IN82, Q8IN83, Q8IS35, Q8IS36, Q9GU18, Q9GU19, Q9GU20, Q9GU21, Q9GU22, Q9VE64, Q9VE65, Q9VE66, Q9VE67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: January 16, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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