Oo18 RNA-binding protein, isoform B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mRNA 3'-UTR binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mRNA binding Source: FlyBase <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "The drosophila melanogaster genome: translation factors and RNA binding proteins."
    Lasko P.
    J Cell Biol 150:F51-6(2000) [PubMed] [Europe PMC] [Abstract]
• ribosome binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• translation factor activity, RNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• translation repressor activity, mRNA regulatory element binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Rasputin functions as a positive regulator of orb in Drosophila oogenesis."
    Costa A., Pazman C., Sinsimer K.S., Wong L.C., McLeod I., Yates J., Haynes S., Schedl P.
    PLoS One 8:e72864-e72864(2013) [PubMed] [Europe PMC] [Abstract]
• germ cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Cytoplasmic localization and evolutionary conservation of MEI-218, a protein required for meiotic crossing-over in Drosophila."
    Manheim E.A., Jang J.K., Dominic D., McKim K.S.
    Mol Biol Cell 13:84-95(2002) [PubMed] [Europe PMC] [Abstract]
• mRNA polyadenylation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte."
    Castagnetti S., Ephrussi A.
    Development 130:835-843(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cytoplasmic translation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• oocyte anterior/posterior axis specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis."
    Christerson L.B., McKearin D.M.
    Genes Dev 8:614-628(1994) [PubMed] [Europe PMC] [Abstract]
• oocyte dorsal/ventral axis specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway."
    Costa A., Wang Y., Dockendorff T.C., Erdjument-Bromage H., Tempst P., Schedl P., Jongens T.A.
    Dev Cell 8:331-342(2005) [PubMed] [Europe PMC] [Abstract]
  • "orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis."
    Christerson L.B., McKearin D.M.
    Genes Dev 8:614-628(1994) [PubMed] [Europe PMC] [Abstract]
• pole plasm oskar mRNA localization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis."
    Christerson L.B., McKearin D.M.
    Genes Dev 8:614-628(1994) [PubMed] [Europe PMC] [Abstract]
• regulation of oskar mRNA translation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte."
    Castagnetti S., Ephrussi A.
    Development 130:835-843(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLGVEKPYVV EPAMAVAQDS FEFGSNGDGS STNSHTSNAS SKDLGRLTSG 
        60         70         80         90        100
DGAQNFAQDS SANSIDQDST DNTNSDCNPI TLNDLLGLCG ASTANEVVGT 
       110        120        130        140        150
GQTPSTSAPI LGAGGGGRAN GVTAGAATAT GVGVGAGGTL PGPGVPSIQG 
       160        170        180        190        200
GGGGGVVGQQ TNASCNTSAA NPSASFGGNG SSSDVNNLLL ASAAAAAAAA 
       210        220        230        240        250
AGDGAQLSAN AAAYAPLTPS STHSSASPGT KSNFDYFQFE NVAQSNPLKA 
       260        270        280        290        300
FQRTNISFDC SAPLSPSTPT SIYNRSFHSS PLVSDSSNSS SGIGLSMDSI 
       310        320        330        340        350
NMFYNQQQQQ QQPEQQGYTS LGNSMGSGLG LSLANASTRS NSPESQNSSN 
       360        370        380        390        400
STTEQNLLDM INLLSVNSNK IPHQQQQQQQ QQQQQQQQQQ QNQQQLQVQQ 
       410        420        430        440        450
QHQLQQQFVN LNRNYEQQIS ANLGSQQHGF EHNGVGVGAS SSGNENCFSQ 
       460        470        480        490        500
YNLENITSVD MELAKLQNLQ RINTLKLLHA QAQQMPLINQ LLQSYAGNAI 
       510        520        530        540        550
GSVGGSNLGN LMSAGGSSLM TEMAGNVGGI ITTNDGHLDR VAKFYKSSAA 
       560        570        580        590        600
LCDATCTWSG HLPPRSHRML NYSPKVFLGG IPWDISEQSL IQIFKPFGSI 
       610        620        630        640        650
KVEWPGKEQQ AAQPKGYVYI IFESDKQVKA LLSACVLQVD DSHCGRNYFF 
       660        670        680        690        700
KISSRRIKSK DVEVIPWIIA DSNFVRSSSQ KLDPTKTVFV GALHGKLTAE 
       710        720        730        740        750
GLGNIMDDLF DGVLYAGIDT DKYKYPIGSG RVTFSNFRSY MKAVSAAFIE 
       760        770        780        790        800
IRTTKFTKKV QVDPYLEDAL CSICGVQHGP YYCRELSCFR YFCRSCWQWQ 
       810        820        830        840        850
HSCDIVKNHK PLTRNSKSQS LVGIGPSSSN VSLPFSGQRS IRDNRMGNGQ 
       860        870        880        890        900
HQQHQQHQYQ QQKHRQLQEY SQPHSLNVMG NSGAANAAAT SMVTLQQRQI 
       910 
HKVRIQRQQH QAI                                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ