UniProtKB - Q8IMC2 (Q8IMC2_DROME)
Protein
Receptor protein-tyrosine kinase
Gene
Eph
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 726 | ATPUniRule annotation | 1 | |
Active sitei | 819 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 698 – 706 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane-ephrin receptor activity Source: FlyBase
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- ephrin receptor signaling pathway Source: FlyBase
- melanotic encapsulation of foreign target Source: FlyBase
- multicellular organism development Source: GO_Central
- mushroom body development Source: FlyBase
- peripheral nervous system development Source: FlyBase
- positive regulation of kinase activity Source: GO_Central
- protein autophosphorylation Source: FlyBase
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, ReceptorImportedARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EphImported Synonyms:CT3831Imported, DEKImported, DekImported, dekImported, Dek7Imported, DephImported, Dmel\CG1511Imported, Ek7Imported, ephImported, lincRNA.923Imported, RPTK Dek7Imported ORF Names:CG1511Imported, Dmel_CG1511Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0025936, Eph |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: FlyBase
Other locations
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 606 – 629 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0025936, Expressed in central nervous system and 43 other tissues |
ExpressionAtlasi | Q8IMC2, baseline and differential |
Genevisiblei | Q8IMC2, DM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 233 | Eph LBDInterPro annotationAdd BLAST | 184 | |
Domaini | 356 – 464 | Fibronectin type-IIIInterPro annotationAdd BLAST | 109 | |
Domaini | 500 – 593 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 692 – 961 | Protein kinaseInterPro annotationAdd BLAST | 270 | |
Domaini | 990 – 1046 | SAMInterPro annotationAdd BLAST | 57 |
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000165255 |
OMAi | WQTDSYK |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS50105, SAM_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8IMC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKSALKSAF YKNQAPISEQ NRSQIVSRMS LLRTILLIII SIHFKLAHAD
60 70 80 90 100
QVVLLDTTRE ATLEWTRYPY GPQAQTPGWV EESFTDFVKG INWRSYVVCD
110 120 130 140 150
VAYHNVNNWL WSPFIDRGSA NRLYIEIQFT IRDCSLFPGN ALSCKETFSL
160 170 180 190 200
LFYEFDAATR EPPPWQTDSY RLIARIAAGE GRFNQNSDVD INTEVKSIAV
210 220 230 240 250
NKKGVYFAFR DQGACISVLA VKVYYITCPA VTENFAHFNE TPTGREITII
260 270 280 290 300
EKQNGTCVDN AEPYETPTYL CKGDGKWTIL TGGCRCKAGY EPNYTNKTCT
310 320 330 340 350
ECPLGTFKSP EVTKCTPCPP NSNASKTGSP FCKCASGFYR HPNDGRHMPC
360 370 380 390 400
YSPPAAPTNL TLLFVDQTSA IISWSAPAKN ESFSSETNSK IYHSDIVYKI
410 420 430 440 450
KCNICSPNVV YNPSTDTFNE TKITLTNLEP VTTYTVQIHA INSVSHINEF
460 470 480 490 500
KRHSNESSLV AVSDIVFSNT SLLNIPLDLN EVKTGQAEIV FTTESVLLST
510 520 530 540 550
VFNLRILAIT NKDADLEWDK PVQSDFPLEF YEVRWFPKVE LDAINKSALN
560 570 580 590 600
TKETKAHIVG LLENTEYGFQ VRCKTNNGFG SYSNMIYAQT LQSVGSVYDD
610 620 630 640 650
SVQIRFIAGA IVTGVLFLVI FIIATVYFMR SKHQDDLDKK STNHLPLPLD
660 670 680 690 700
YASNEVTTPL FGNSRSYVDP HTYEDPNQAI REFAREIDAN YITIEAIIGG
710 720 730 740 750
GEFGDVCRGR LKIPPNFVQD IDVAIKTLKP GSSEKARCDF LTEASIMGQF
760 770 780 790 800
DHPNVIYLQG VVTRSNPVMI ITEYMENGSL DTFLRVNDGK FQTLQLIVML
810 820 830 840 850
RGIASGMSYL SDMNYVHRDL AARNVLVNAQ LICKIADFGL SREIENASDA
860 870 880 890 900
YTTRGGKIPV RWTAPEAIAF RKFTSASDVW SYGVVLWEVM SYGERPYWNW
910 920 930 940 950
SNQDVIKSIE KGYRLPAPMD CPEALYQLML DCWQKQRTHR PTFASIVSTL
960 970 980 990 1000
DNLARQPQSL LTTRPSPESD GNHILDGQRG QNIFISTDLW LEHIKMSRYC
1010 1020 1030 1040
HHFKEANLIN AQQISRLTAQ QLSDMGITLV GHQKKILHQA RQLDTII
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9V4E5 | Q9V4E5_DROME | Receptor protein-tyrosine kinase | Eph CT3831, DEK, Dek, dek, Dek7 | 1,096 | Annotation score: | ||
Q0KIF4 | Q0KIF4_DROME | Receptor protein-tyrosine kinase | Eph CT3831, DEK, Dek, dek, Dek7 | 1,080 | Annotation score: | ||
D1YSF9 | D1YSF9_DROME | Receptor protein-tyrosine kinase | Eph CT3831, DEK, Dek, dek, Dek7 | 1,005 | Annotation score: | ||
Q59DQ4 | Q59DQ4_DROME | Receptor protein-tyrosine kinase | Eph CT3831, DEK, Dek, dek, Dek7 | 1,080 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014135 Genomic DNA Translation: AAN06504.2 |
RefSeqi | NP_726591.2, NM_166777.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0089083; FBpp0088152; FBgn0025936 |
GeneIDi | 43803 |
UCSCi | CG1511-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014135 Genomic DNA Translation: AAN06504.2 |
RefSeqi | NP_726591.2, NM_166777.4 |
3D structure databases
SMRi | Q8IMC2 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0089083; FBpp0088152; FBgn0025936 |
GeneIDi | 43803 |
UCSCi | CG1511-RB, d. melanogaster |
Organism-specific databases
CTDi | 43803 |
FlyBasei | FBgn0025936, Eph |
Phylogenomic databases
GeneTreei | ENSGT00940000165255 |
OMAi | WQTDSYK |
Miscellaneous databases
BioGRID-ORCSi | 43803, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43803 |
Gene expression databases
Bgeei | FBgn0025936, Expressed in central nervous system and 43 other tissues |
ExpressionAtlasi | Q8IMC2, baseline and differential |
Genevisiblei | Q8IMC2, DM |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IMC2_DROME | |
Accessioni | Q8IMC2Primary (citable) accession number: Q8IMC2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | April 26, 2005 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |