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Entry version 152 (10 Feb 2021)
Sequence version 2 (13 Nov 2007)
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Protein

Protein pangolin, isoform J

Gene

pan

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi714 – 782HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor, Segmentation polarity protein
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-201722, Formation of the beta-catenin:TCF transactivating complex
R-DME-3769402, Deactivation of the beta-catenin transactivating complex
R-DME-4086398, Ca2+ pathway
R-DME-4641265, Repression of WNT target genes
R-DME-8853884, Transcriptional Regulation by VENTX
R-DME-8951430, RUNX3 regulates WNT signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein pangolin, isoform J
Alternative name(s):
dTCF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:panImported
Synonyms:TCF1 Publication
ORF Names:CG34403
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0085432, pan

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit a segment polarity phenotype and altered expression of the wg target genes en and Ubx.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225571 – 1192Protein pangolin, isoform JAdd BLAST1192

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IMA8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IMA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0085432, Expressed in central nervous system and 42 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IMA8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IMA8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the beta-catenin homolog arm or to gro.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
68607, 66 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IMA8, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0111569

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IMA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi351 – 357Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi197 – 200Poly-AsnSequence analysis4
Compositional biasi489 – 494Poly-SerSequence analysis6
Compositional biasi792 – 798Poly-LysSequence analysis7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCF/LEF family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3248, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168653

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_271719_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IMA8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IMA8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR028782, Pangolin-like
IPR024940, TCF/LEF

The PANTHER Classification System

More...
PANTHERi
PTHR10373, PTHR10373, 1 hit
PTHR10373:SF38, PTHR10373:SF38, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00505, HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform J1 Publication (identifier: Q8IMA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHCGTTNSE INLNSNELIS YQKKKSNEDL QKKHDKKCSI NLKTSQVPDG
60 70 80 90 100
GFNNQYTQLT ANKIEQYNCN DLDKVCIVPS SRSDGMEASF SELLLSPNKL
110 120 130 140 150
ISQPWQTAEE IENWQNDSFR QRNEMFSCIY TNSMLNQQPC SQQQLLATQL
160 170 180 190 200
LYARLLRSQL AEREFHSNKF NMVHYSGSKK TMLREDELLS TPSSQDNNNN
210 220 230 240 250
IKLIKDIENS ISCVDPPLFE FSNVHQRAEQ KNKQDDKNCY SPKLKSNKEA
260 270 280 290 300
LDGYDLQHTC DFIREQKNIL IDIKKKLDNL SDSSGKFRKR LSVRQSHIEV
310 320 330 340 350
NNGSNSALEE SVRRQLNGNR KSIENLLEEV KRLYNQWSSA ELYYVRSLQR
360 370 380 390 400
LGLPSEEDGE YTSTPTHTIM ALAAIALSNE SILPQKTNAV HSKIPDVESE
410 420 430 440 450
SDFFLTSAKP KTLVEIEDII LQLASSVNMH QSSSASTPHE SYSDSVKSDC
460 470 480 490 500
EESNSAPTCI WHSTRQTFRH KKDVEPCSTA AEIILEYASL SSSSNIETSR
510 520 530 540 550
LLTSASNLTD VTENYNVTTQ LPIVFNYNRE SSAESIVTDP LLVPEFSTAP
560 570 580 590 600
STPSTGSNSG CSTGMVSGIF GLSQNRRKQR LARHIETLTT NSFKSNAIRG
610 620 630 640 650
NVDNEITNQL KTSPSIRALP TENVSHLITK TLSSANASLT AQELSITNLF
660 670 680 690 700
KERLCALQGN AGSMKTEIFP MIDAPYDLSI GSKTKHMNLE AKHTSNAQSN
710 720 730 740 750
ESKETTNDKK KPHIKKPLNA FMLYMKEMRA KVVAECTLKE SAAINQILGR
760 770 780 790 800
RWHELSREEQ SKYYEKARQE RQLHMELYPG WSARDNYGYV SKKKKRKKDR
810 820 830 840 850
STTDSGGNNM KKCRARFGLD QQSQWCKPCR RKKKCIRYME ALNGNGPAED
860 870 880 890 900
GSCFDEHGSQ LSDDDEDDYD DDKLGGSCGS ADETNKIEDE DSESLNQSMP
910 920 930 940 950
SPGCLSGLSS LQSPSTTMSL ASPLNMNANS ATNVIFPASS NALLIVGADQ
960 970 980 990 1000
PTAQQRPTLV STSGSSSGST SSISTTPNTS STVSPVTCMT GPCLGSSQER
1010 1020 1030 1040 1050
AMMLGNRFSH LGMGLSPPVV STSTSKSEPF FKPHPTVCNN PIFALPSIGN
1060 1070 1080 1090 1100
CSLNISSMPN TSRNPIGANP RDINNPLSIN QLTKRREYKN VELIEASESK
1110 1120 1130 1140 1150
TIVAHAATSI IQHVAVNGYH ANHSLLNSNL GHLHHQLNNR TENPNRSEQT
1160 1170 1180 1190
MLSVSNHSVN SSECHKESDS QAIVSSNPPN AGSSDNGVIS VS
Length:1,192
Mass (Da):132,080
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i173ED73F8673DAA6
GO
Isoform S (identifier: P91943-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P91943.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:733
Mass (Da):79,936
GO
Isoform A1 Publication (identifier: P91943-3) [UniParc]FASTAAdd to basket
Also known as: C1 Publication, D1 Publication, E1 Publication, F1 Publication, G1 Publication
The sequence of this isoform can be found in the external entry P91943.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:751
Mass (Da):81,892
GO
Isoform H1 Publication (identifier: P91943-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P91943.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:747
Mass (Da):81,391
GO
Isoform I1 Publication (identifier: P91943-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P91943.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:410
Mass (Da):46,291
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P91943PANG1_DROME
Protein pangolin, isoforms A/H/I/S
pan TCF, CG34403
751Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9XVM0H9XVM0_DROME
Pangolin, isoform Q
pan CG17964, CG32005, d-TCF, Dm Pan, Dmel\CG34403
494Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAN06549.2
BT029282 mRNA Translation: ABK30919.1
AY312729 Genomic DNA Translation: AAQ67543.1
AY312730 Genomic DNA Translation: AAQ67544.1
AY312731 Genomic DNA Translation: AAQ67545.1
AY312732 Genomic DNA Translation: AAQ67546.1
AY312733 Genomic DNA Translation: AAQ67547.1
AY312734 Genomic DNA Translation: AAQ67548.1
AY312735 Genomic DNA Translation: AAQ67549.1
AY312736 Genomic DNA Translation: AAQ67550.1
AY312737 Genomic DNA Translation: AAQ67551.1
AY312738 Genomic DNA Translation: AAQ67552.1
AY312739 Genomic DNA Translation: AAQ67553.1
AY312740 Genomic DNA Translation: AAQ67554.1
AY312741 Genomic DNA Translation: AAQ67555.1
AY312742 Genomic DNA Translation: AAQ67556.1
AY312743 Genomic DNA Translation: AAQ67557.1
AY312744 Genomic DNA Translation: AAQ67558.1
AY312745 Genomic DNA Translation: AAQ67559.1
AY312746 Genomic DNA Translation: AAQ67560.1
AY312747 Genomic DNA Translation: AAQ67561.1
AY312748 Genomic DNA Translation: AAQ67562.1
AY312749 Genomic DNA Translation: AAQ67563.1
AY312750 Genomic DNA Translation: AAQ67564.1
AY312751 Genomic DNA Translation: AAQ67565.1
AY312752 Genomic DNA Translation: AAQ67566.1

NCBI Reference Sequences

More...
RefSeqi
NP_726528.2, NM_166724.4 [Q8IMA8-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0112657; FBpp0111569; FBgn0085432 [Q8IMA8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43769

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAN06549.2
BT029282 mRNA Translation: ABK30919.1
AY312729 Genomic DNA Translation: AAQ67543.1
AY312730 Genomic DNA Translation: AAQ67544.1
AY312731 Genomic DNA Translation: AAQ67545.1
AY312732 Genomic DNA Translation: AAQ67546.1
AY312733 Genomic DNA Translation: AAQ67547.1
AY312734 Genomic DNA Translation: AAQ67548.1
AY312735 Genomic DNA Translation: AAQ67549.1
AY312736 Genomic DNA Translation: AAQ67550.1
AY312737 Genomic DNA Translation: AAQ67551.1
AY312738 Genomic DNA Translation: AAQ67552.1
AY312739 Genomic DNA Translation: AAQ67553.1
AY312740 Genomic DNA Translation: AAQ67554.1
AY312741 Genomic DNA Translation: AAQ67555.1
AY312742 Genomic DNA Translation: AAQ67556.1
AY312743 Genomic DNA Translation: AAQ67557.1
AY312744 Genomic DNA Translation: AAQ67558.1
AY312745 Genomic DNA Translation: AAQ67559.1
AY312746 Genomic DNA Translation: AAQ67560.1
AY312747 Genomic DNA Translation: AAQ67561.1
AY312748 Genomic DNA Translation: AAQ67562.1
AY312749 Genomic DNA Translation: AAQ67563.1
AY312750 Genomic DNA Translation: AAQ67564.1
AY312751 Genomic DNA Translation: AAQ67565.1
AY312752 Genomic DNA Translation: AAQ67566.1
RefSeqiNP_726528.2, NM_166724.4 [Q8IMA8-1]

3D structure databases

SMRiQ8IMA8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68607, 66 interactors
IntActiQ8IMA8, 9 interactors
STRINGi7227.FBpp0111569

Proteomic databases

PaxDbiQ8IMA8
PRIDEiQ8IMA8

Genome annotation databases

EnsemblMetazoaiFBtr0112657; FBpp0111569; FBgn0085432 [Q8IMA8-1]
GeneIDi43769

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43769
FlyBaseiFBgn0085432, pan

Phylogenomic databases

eggNOGiKOG3248, Eukaryota
GeneTreeiENSGT00940000168653
HOGENOMiCLU_271719_0_0_1
InParanoidiQ8IMA8
PhylomeDBiQ8IMA8

Enzyme and pathway databases

ReactomeiR-DME-201722, Formation of the beta-catenin:TCF transactivating complex
R-DME-3769402, Deactivation of the beta-catenin transactivating complex
R-DME-4086398, Ca2+ pathway
R-DME-4641265, Repression of WNT target genes
R-DME-8853884, Transcriptional Regulation by VENTX
R-DME-8951430, RUNX3 regulates WNT signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43769, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
pan, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43769

Gene expression databases

BgeeiFBgn0085432, Expressed in central nervous system and 42 other tissues
ExpressionAtlasiQ8IMA8, baseline and differential
GenevisibleiQ8IMA8, DM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR028782, Pangolin-like
IPR024940, TCF/LEF
PANTHERiPTHR10373, PTHR10373, 1 hit
PTHR10373:SF38, PTHR10373:SF38, 1 hit
PfamiView protein in Pfam
PF00505, HMG_box, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANG2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IMA8
Secondary accession number(s): A0AVW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 13, 2007
Last modified: February 10, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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