UniProtKB - Q8ILY9 (Q8ILY9_PLAF7)
Protein
Protein-synthesizing GTPase
Gene
PF3D7_1410600
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
- EC:3.6.5.3ARBA annotation
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: GeneDB
- translation initiation factor activity Source: GO_Central
- tRNA binding Source: InterPro
GO - Biological processi
- formation of translation preinitiation complex Source: GO_Central
- positive regulation of translational fidelity Source: GO_Central
- translational initiation Source: GeneDB
Keywordsi
Molecular function | HydrolaseARBA annotation, Initiation factorImportedARBA annotation |
Biological process | Protein biosynthesis |
Ligand | GTP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-PFA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-PFA-381042, PERK regulates gene expression R-PFA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-PFA-72702, Ribosomal scanning and start codon recognition R-PFA-72731, Recycling of eIF2:GDP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1410600Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1410600 |
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: GO_Central
- cytosol Source: GO_Central
- eukaryotic translation initiation factor 2 complex Source: GeneDB
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 241 | Tr-type GInterPro annotationAdd BLAST | 209 |
Phylogenomic databases
HOGENOMi | CLU_027154_0_1_1 |
OMAi | NIGMVGH |
Family and domain databases
CDDi | cd01888, eIF2_gamma, 1 hit cd03688, eIF2_gamma_II, 1 hit cd15490, eIF2_gamma_III, 1 hit |
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR015256, eIF2g_C IPR044127, eIF2g_dom_2 IPR044128, eIF2g_GTP-bd IPR027417, P-loop_NTPase IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C |
Pfami | View protein in Pfam PF09173, eIF2_C, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51722, G_TR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8ILY9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNINEKDKLA EQNLETLDVT KLTPLSEDVI SRQATINLGT IGHVAHGKST
60 70 80 90 100
LVHAISGVHT VRFKHEKERN ITIKLGYANA KIYKCTNPDC LPPECYKSYE
110 120 130 140 150
SSKEDNPICP RKDCNHEMKL LRHVSFVDCP GHDILMATML NGAAVMDAAL
160 170 180 190 200
LLVAGNESCP QPQTSEHLAA VEIMRLKHIL ILQNKVELIK EEQALKQQEE
210 220 230 240 250
IRNFVSGTAA DSAPIIPISA VLKYNIDVVC EYIVTQISIP KRDFISSPHM
260 270 280 290 300
IVIRSFDVNK PGEDIETLQG GVAGGSILHG VLKVGDKIEI RPGIISKDDK
310 320 330 340 350
GEITCRPIIS QILSMFAENN NLKYAVPGGL IGVGTKIDPI LTRADRLVGQ
360 370 380 390 400
VIGHLNKLPD CFAEIEISYY LLRRLLGVKS QDGEKNTKVA KLKNGEFLMI
410 420 430 440 450
NIGSTSIGCR VTGIKTELAK LELTGPVCTK IGDKIALSRR VDKHWRLIGW
460
GQINKGKPLE LQEPI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZT99814.1 |
RefSeqi | XP_001348277.1, XM_001348241.1 |
Genome annotation databases
EnsemblProtistsi | CZT99814; CZT99814; PF3D7_1410600 |
GeneDBi | PF3D7_1410600.1:pep |
GeneIDi | 811685 |
KEGGi | pfa:PF3D7_1410600 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZT99814.1 |
RefSeqi | XP_001348277.1, XM_001348241.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | Q8ILY9 |
Proteomic databases
PRIDEi | Q8ILY9 |
Genome annotation databases
EnsemblProtistsi | CZT99814; CZT99814; PF3D7_1410600 |
GeneDBi | PF3D7_1410600.1:pep |
GeneIDi | 811685 |
KEGGi | pfa:PF3D7_1410600 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1410600 |
Phylogenomic databases
HOGENOMi | CLU_027154_0_1_1 |
OMAi | NIGMVGH |
Enzyme and pathway databases
Reactomei | R-PFA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-PFA-381042, PERK regulates gene expression R-PFA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-PFA-72702, Ribosomal scanning and start codon recognition R-PFA-72731, Recycling of eIF2:GDP |
Family and domain databases
CDDi | cd01888, eIF2_gamma, 1 hit cd03688, eIF2_gamma_II, 1 hit cd15490, eIF2_gamma_III, 1 hit |
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR015256, eIF2g_C IPR044127, eIF2g_dom_2 IPR044128, eIF2g_GTP-bd IPR027417, P-loop_NTPase IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C |
Pfami | View protein in Pfam PF09173, eIF2_C, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51722, G_TR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8ILY9_PLAF7 | |
Accessioni | Q8ILY9Primary (citable) accession number: Q8ILY9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |