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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

PF14_0127

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.By similarity

Catalytic activityi

Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein].

GO - Molecular functioni

GO - Biological processi

  • N-terminal peptidyl-glycine N-myristoylation Source: GO_Central
  • response to drug Source: GeneDB

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97 4889

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name:
NMT
Peptide N-myristoyltransferase
Gene namesi
ORF Names:PF14_0127
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1412800

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2169722

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642301 – 410Glycylpeptide N-tetradecanoyltransferaseAdd BLAST410

Proteomic databases

PRIDEiQ8ILW6

PTM databases

SwissPalmiQ8ILW6

Interactioni

Chemistry databases

BindingDBiQ8ILW6

Structurei

3D structure databases

ProteinModelPortaliQ8ILW6
SMRiQ8ILW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 31Myristoyl-CoA bindingBy similarity3
Regioni163 – 165Myristoyl-CoA bindingBy similarity3
Regioni171 – 175Myristoyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

HOGENOMiHOG000189123
InParanoidiQ8ILW6
KOiK00671
OMAiYNWRCPG
PhylomeDBiQ8ILW6

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ILW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDDKKDFVG RDLYQLIRNA KDKIKIDYKF WYTQPVPKIN DEFDENVNEP
60 70 80 90 100
FISDNKVEDV RKEEYKLPSG YAWCVCDITK ENDRSDIYNL LTDNYVEDDD
110 120 130 140 150
NVFRFNYSSE FLLWALSSPN YVKNWHIGVK YESTNKLVGF ISAIPIDMCV
160 170 180 190 200
NKNIIKMAEV NFLCVHKSLR SKRLAPVLIK EITRRINLES IWQAIYTAGV
210 220 230 240 250
YLPKPISTAR YFHRSINVKK LIEIGFSCLN TRLTMSRAIK LYRIDDTLNI
260 270 280 290 300
KNLRLMKKKD IDGLQKLLNE HLKQYNLHAI FSKEDVAHWF TPIDQVIYTY
310 320 330 340 350
VNEENGEIKD LISFYSLPSK VLGNNKYNIL NAAFSFYNIT TTTTFKNLIQ
360 370 380 390 400
DAICLAKRNN FDVFNALEVM DNYSVFQDLK FGEGDGSLKY YLYNWKCASC
410
HPSKIGIVLL
Length:410
Mass (Da):47,970
Last modified:March 1, 2003 - v1
Checksum:iAA823DD100D80C10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN36739.1
RefSeqiXP_001348300.1, XM_001348264.1

Genome annotation databases

GeneDBiPF3D7_1412800.1:pep
GeneIDi811708
KEGGipfa:PF3D7_1412800

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN36739.1
RefSeqiXP_001348300.1, XM_001348264.1

3D structure databases

ProteinModelPortaliQ8ILW6
SMRiQ8ILW6
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ8ILW6
ChEMBLiCHEMBL2169722

PTM databases

SwissPalmiQ8ILW6

Proteomic databases

PRIDEiQ8ILW6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiPF3D7_1412800.1:pep
GeneIDi811708
KEGGipfa:PF3D7_1412800

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1412800

Phylogenomic databases

HOGENOMiHOG000189123
InParanoidiQ8ILW6
KOiK00671
OMAiYNWRCPG
PhylomeDBiQ8ILW6

Enzyme and pathway databases

BRENDAi2.3.1.97 4889

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMT_PLAF7
AccessioniPrimary (citable) accession number: Q8ILW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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