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Protein

Uracil-DNA glycosylase

Gene

PF3D7_1415000

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169Proton acceptorUniRule annotation1

GO - Molecular functioni

  • uracil DNA N-glycosylase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseImported, Hydrolase
Biological processDNA damage, DNA repairUniRule annotation

Enzyme and pathway databases

ReactomeiR-PFA-110329 Cleavage of the damaged pyrimidine
R-PFA-110357 Displacement of DNA glycosylase by APEX1

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
ORF Names:PF3D7_1415000Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1415000

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

MitochondrionUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8ILU6

Structurei

3D structure databases

SMRiQ8ILU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

KOiK03648
OMAiDNGYLMP

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ILU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNPTIQKTI DQFFKVKRKS SILSGEIEKK RKKVILEEVE EKSLEGSLKE
60 70 80 90 100
ENVNILKTKK LMNNDEDIEK MGTISNISMS TSTIDNEINN NVKQNVCEQG
110 120 130 140 150
YMEEIKKLMH IEWYELLKDE LKKNYFKNMY LKIKEERKTK VIYPPEQLVF
160 170 180 190 200
NAFLKTPLSN IKVVIVGQDP YHQKDQAMGL CFSVPIGVKI PPSLKNILKE
210 220 230 240 250
MKQKSNHGNL ISWSEQGVFL LNTSLTVEEN KPASHKNYGW ETFTDTVINI
260 270 280 290 300
INRQKEKIIF MLWGNFAIKK CKNIDINKHF ILKAGHPSPL SIKHFENCNH
310 320
FAKCNKILAQ HNLTPIKWEL PQ
Length:322
Mass (Da):37,461
Last modified:March 1, 2003 - v1
Checksum:iDF9AF469A2098C38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZT99861.1
RefSeqiXP_001348321.1, XM_001348285.1

Genome annotation databases

EnsemblProtistsiCZT99861; CZT99861; PF3D7_1415000
GeneDBiPF3D7_1415000.1:pep
GeneIDi811729
KEGGipfa:PF3D7_1415000

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZT99861.1
RefSeqiXP_001348321.1, XM_001348285.1

3D structure databases

SMRiQ8ILU6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8ILU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZT99861; CZT99861; PF3D7_1415000
GeneDBiPF3D7_1415000.1:pep
GeneIDi811729
KEGGipfa:PF3D7_1415000

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1415000

Phylogenomic databases

KOiK03648
OMAiDNGYLMP

Enzyme and pathway databases

ReactomeiR-PFA-110329 Cleavage of the damaged pyrimidine
R-PFA-110357 Displacement of DNA glycosylase by APEX1

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8ILU6_PLAF7
AccessioniPrimary (citable) accession number: Q8ILU6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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