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Entry version 97 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Surface protein P113

Gene

P113

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane receptor which tethers secreted RH5 to the merozoite membrane during merozoite invasion of host erythocytes.

1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Surface protein P113Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P1131 Publication
ORF Names:PF3D7_1420700Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_1420700

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501910773423 – 945Surface protein P113Sequence analysisAdd BLAST923
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000448667946 – 969Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi207N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi268N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi317N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi360N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi661N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi697N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi779N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi876N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi938N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi941N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi945GPI-anchor amidated asparagineSequence analysis1
Glycosylationi945N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8ILP3

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8ILP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186). Within the complex, interacts with RH5 (via N-terminus); the interaction tethers RH5 to the merozoite membrane (PubMed:28186186).

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8ILP3, 9 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1969
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8ILP3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni223 – 328DisorderedSequence analysisAdd BLAST106
Regioni688 – 947DisorderedSequence analysisAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi229 – 261Polar residuesSequence analysisAdd BLAST33
Compositional biasi272 – 297Polar residuesSequence analysisAdd BLAST26
Compositional biasi311 – 326Polar residuesSequence analysisAdd BLAST16
Compositional biasi688 – 724Polar residuesSequence analysisAdd BLAST37
Compositional biasi725 – 771Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi782 – 796Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi808 – 824Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi838 – 853Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi861 – 921Basic and acidic residuesSequence analysisAdd BLAST61

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_306005_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NATIHYT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8ILP3

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ILP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIPFFILHI LLLQFLLCLI RCYVHNDVIK FGEENSLKCS QGNLYVLHCE
60 70 80 90 100
VQCLNGNNEI IHKRCNDDIE KKCNGNNKCI YFFEYELRKK TQSFRNKNSI
110 120 130 140 150
EISECVESEQ NEVKTSTTCL LSNSFILDEA FIQYFFFIKN KNEEPVICKD
160 170 180 190 200
GNINIKSALL HSPFCEIKLK DISEYIRKKC DNNKECLIDP LDVQKNLLNE
210 220 230 240 250
EDPCYINNSY VSVNVVCNKE EEIGDESTDS SSMEIQDSTS NEQDENVKGM
260 270 280 290 300
SSSQEMNSNN DENKNQDNES DDDVNNNNNN NNDDQDEQGN DGDVTSSMNK
310 320 330 340 350
NEDNKDLEHG SSNDVNNNTD TLVNNKENKE FVLKEKSSLT SKINKELAHR
360 370 380 390 400
TALFNKLADN ISLLLNKKYD SFEIKDVLED RYNEMKRDAN PDVYYIYLMD
410 420 430 440 450
TLDIEKIEDI NLEEVKMSLL ASLKETMNKI DTIEKKIEEF KNKYISLYNK
460 470 480 490 500
VKTTMPELFD LNEDLVLLYN DFPFDNGMIS SDIFFKYNPS ENIMDHQEMV
510 520 530 540 550
KKGSITEDEL RIVNDLEPLD NYRRRKRITE LRKILVEKLR ILYLEKNNLF
560 570 580 590 600
NTQASCIKSY CYKNPLNLKT LEVLLKKNYY RLKENKDYDV VSSIIQHLDN
610 620 630 640 650
VDANKKKKWL THERILKKLQ VLIAEGYKRI NEKEKDIDRR MAVYNALYEK
660 670 680 690 700
AQSYNLQKLF NDSNDFLKKY AIMGNSFDDG DEVFGSQSSN FNIFDSNNTD
710 720 730 740 750
QNNEQEQPKQ DDQLLNNNND DVLSESNNEN KEKTSDDATH KETQEKSDQE
760 770 780 790 800
PSQNIQEDNS DEKHAENEEN VEQIETDSNV SEEANDENKD NMQTTTDEGT
810 820 830 840 850
EELQQNDEDA ESLTKENSKS EEQENEDSTD AEAIDKEEVE TEEKGKDEQK
860 870 880 890 900
KDEQKEQDEE EDGEKENKHK SSETTNETVT DIEENKNEVK GEEHLQGSEQ
910 920 930 940 950
SIEASESSQK DETKETEDKE EYVNANDDES SEEDTTPNET NKTDNGSSFF
960
FAMSNALLVI LLLLFIEFL
Length:969
Mass (Da):112,574
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i323C98B89520153C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZT99914.1

NCBI Reference Sequences

More...
RefSeqi
XP_001348374.1, XM_001348338.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT99914; CZT99914; PF3D7_1420700

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1420700.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
811782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1420700

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZT99914.1
RefSeqiXP_001348374.1, XM_001348338.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6Z2LX-ray1.95A23-219[»]
SMRiQ8ILP3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ8ILP3, 9 interactors

PTM databases

SwissPalmiQ8ILP3

Proteomic databases

PRIDEiQ8ILP3

Genome annotation databases

EnsemblProtistsiCZT99914; CZT99914; PF3D7_1420700
GeneDBiPF3D7_1420700.1:pep
GeneIDi811782
KEGGipfa:PF3D7_1420700

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1420700

Phylogenomic databases

HOGENOMiCLU_306005_0_0_1
OMAiNATIHYT
PhylomeDBiQ8ILP3

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP113_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8ILP3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2019
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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