UniProtKB - Q8ILA4 (Q8ILA4_PLAF7)
Protein
Glucose-6-phosphate isomerase
Gene
PF3D7_1436000
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
- EC:5.3.1.9UniRule annotationARBA annotation
: glycolysis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationARBA annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Phosphotransferase (PF3D7_0624000)
- Glucose-6-phosphate isomerase (PF3D7_1436000)
- ATP-dependent 6-phosphofructokinase (PF3D7_1128300), Probable ATP-dependent 6-phosphofructokinase (PF3D7_0915400)
- Fructose-bisphosphate aldolase (PF3D7_1444800), Fructose-bisphosphate aldolase (PF14_0425)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 380 | Fructose-6-phosphateCombined sources | 1 | |
Binding sitei | 411 | Fructose-6-phosphateCombined sources | 1 | |
Binding sitei | 540 | Fructose-6-phosphateCombined sources | 1 |
GO - Molecular functioni
- glucose-6-phosphate isomerase activity Source: GO_Central
- monosaccharide binding Source: GO_Central
GO - Biological processi
- gluconeogenesis Source: GeneDB
- glucose 6-phosphate metabolic process Source: GO_Central
- glycolytic process Source: GeneDB
- pentose-phosphate shunt Source: GeneDB
Keywordsi
Molecular function | IsomeraseUniRule annotationImportedARBA annotation |
Biological process | GluconeogenesisUniRule annotationARBA annotation, GlycolysisUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-PFA-5628897, TP53 Regulates Metabolic Genes R-PFA-6798695, Neutrophil degranulation R-PFA-70171, Glycolysis R-PFA-70263, Gluconeogenesis |
UniPathwayi | UPA00109;UER00181 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate isomeraseUniRule annotationARBA annotation (EC:5.3.1.9UniRule annotationARBA annotation) |
Gene namesi | ORF Names:PF3D7_1436000Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1436000 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 159 | Fructose-6-phosphate bindingCombined sources | 2 | |
Regioni | 231 – 236 | Fructose-6-phosphate bindingCombined sources | 6 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_017947_3_1_1 |
OMAi | TNSQHAF |
Family and domain databases
CDDi | cd05015, SIS_PGI_1, 1 hit cd05016, SIS_PGI_2, 1 hit |
Gene3Di | 1.10.1390.10, 1 hit |
HAMAPi | MF_00473, G6P_isomerase, 1 hit |
InterProi | View protein in InterPro IPR001672, G6P_Isomerase IPR023096, G6P_Isomerase_C IPR018189, Phosphoglucose_isomerase_CS IPR035476, SIS_PGI_1 IPR035482, SIS_PGI_2 |
PANTHERi | PTHR11469, PTHR11469, 1 hit |
Pfami | View protein in Pfam PF00342, PGI, 1 hit |
PRINTSi | PR00662, G6PISOMERASE |
PROSITEi | View protein in PROSITE PS00765, P_GLUCOSE_ISOMERASE_1, 1 hit PS00174, P_GLUCOSE_ISOMERASE_2, 1 hit PS51463, P_GLUCOSE_ISOMERASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8ILA4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL
60 70 80 90 100
SRQRYSEKTL NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI
110 120 130 140 150
PIEKINTHKI IIDNKNVLED VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN
160 170 180 190 200
VICIGIGGSY LGTEFVYEAM KYYYYNMELN KNEKDQVNNF NNNYDQDNVF
210 220 230 240 250
NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM LNARSIKKWL
260 270 280 290 300
SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS
310 320 330 340 350
VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS
360 370 380 390 400
HFFDYKNVAI LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV
410 420 430 440 450
YFGEPGTNGQ HSFYQLIHQG QVIPVELIGF KHSHFPIKFD KEVVSNHDEL
460 470 480 490 500
MTNFFAQADA LAIGKTYEQV KEENEKNKMS PELLTHKVFN GNRPSTLLLF
510 520 530 540 550
DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK VLAKEVRNYF
560 570
NDTRNQKKSD NTYNFNESTK ILLNYYLSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZU00058.1 |
RefSeqi | XP_001348515.1, XM_001348479.2 |
Genome annotation databases
EnsemblProtistsi | CZU00058; CZU00058; PF3D7_1436000 |
GeneDBi | PF3D7_1436000.1:pep |
GeneIDi | 811923 |
KEGGi | pfa:PF3D7_1436000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZU00058.1 |
RefSeqi | XP_001348515.1, XM_001348479.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PR3 | X-ray | 2.45 | A/B | 1-579 | [»] | |
3QKI | X-ray | 1.92 | A/B/C | 1-579 | [»] | |
SMRi | Q8ILA4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q8ILA4, 1 interactor |
MINTi | Q8ILA4 |
PTM databases
SwissPalmi | Q8ILA4 |
Proteomic databases
PRIDEi | Q8ILA4 |
Genome annotation databases
EnsemblProtistsi | CZU00058; CZU00058; PF3D7_1436000 |
GeneDBi | PF3D7_1436000.1:pep |
GeneIDi | 811923 |
KEGGi | pfa:PF3D7_1436000 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1436000 |
Phylogenomic databases
HOGENOMi | CLU_017947_3_1_1 |
OMAi | TNSQHAF |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00181 |
Reactomei | R-PFA-5628897, TP53 Regulates Metabolic Genes R-PFA-6798695, Neutrophil degranulation R-PFA-70171, Glycolysis R-PFA-70263, Gluconeogenesis |
Family and domain databases
CDDi | cd05015, SIS_PGI_1, 1 hit cd05016, SIS_PGI_2, 1 hit |
Gene3Di | 1.10.1390.10, 1 hit |
HAMAPi | MF_00473, G6P_isomerase, 1 hit |
InterProi | View protein in InterPro IPR001672, G6P_Isomerase IPR023096, G6P_Isomerase_C IPR018189, Phosphoglucose_isomerase_CS IPR035476, SIS_PGI_1 IPR035482, SIS_PGI_2 |
PANTHERi | PTHR11469, PTHR11469, 1 hit |
Pfami | View protein in Pfam PF00342, PGI, 1 hit |
PRINTSi | PR00662, G6PISOMERASE |
PROSITEi | View protein in PROSITE PS00765, P_GLUCOSE_ISOMERASE_1, 1 hit PS00174, P_GLUCOSE_ISOMERASE_2, 1 hit PS51463, P_GLUCOSE_ISOMERASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8ILA4_PLAF7 | |
Accessioni | Q8ILA4Primary (citable) accession number: Q8ILA4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |