UniProtKB - Q8IL80 (Q8IL80_PLAF7)
Protein
Submitted name:
Thioredoxin peroxidase 1
Gene
PF3D7_1438900
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.UniRule annotation
GO - Molecular functioni
- antioxidant activity Source: GeneDB
- protein dimerization activity Source: GeneDB
- thioredoxin peroxidase activity Source: GeneDB
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- DNA protection Source: GeneDB
- response to heat Source: GeneDB
- response to oxidative stress Source: GeneDB
Keywordsi
Molecular function | AntioxidantUniRule annotation, Oxidoreductase, PeroxidaseUniRule annotationImported |
Enzyme and pathway databases
Reactomei | R-PFA-3299685, Detoxification of Reactive Oxygen Species R-PFA-5628897, TP53 Regulates Metabolic Genes R-PFA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1438900Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1438900 |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: GeneDB
Protein-protein interaction databases
IntActi | Q8IL80, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 162 | ThioredoxinInterPro annotationAdd BLAST | 160 |
Sequence similaritiesi
Belongs to the peroxiredoxin family.UniRule annotation
Keywords - Domaini
Redox-active centerUniRule annotationPhylogenomic databases
HOGENOMi | CLU_042529_21_1_1 |
OMAi | FWYPKDF |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IL80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASYVGREAP YFKAEAVFAD NTFGEVNLHD FIGKKYVLLY FYPLDFTFVC
60 70 80 90 100
PSEIIALDKA LDAFKERNVE LIGCSVDSKY THLAWKKTPL TKGGIGNIQH
110 120 130 140 150
TLISDITKSI SRSYNVLFGD SVSLRAFVLI DKQGVVQHLL VNNLAIGRSV
160 170 180 190
EEVLRIIDAV QHHEQHGDVC PANWKKGKVA MKPSEEGVSE YLSKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZU00085.1 |
RefSeqi | XP_001348542.1, XM_001348506.1 |
Genome annotation databases
EnsemblProtistsi | CZU00085; CZU00085; PF3D7_1438900 |
GeneDBi | PF3D7_1438900.1:pep |
GeneIDi | 811950 |
KEGGi | pfa:PF3D7_1438900 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZU00085.1 |
RefSeqi | XP_001348542.1, XM_001348506.1 |
3D structure databases
SMRi | Q8IL80 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8IL80, 1 interactor |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
SwissPalmi | Q8IL80 |
Proteomic databases
PRIDEi | Q8IL80 |
Genome annotation databases
EnsemblProtistsi | CZU00085; CZU00085; PF3D7_1438900 |
GeneDBi | PF3D7_1438900.1:pep |
GeneIDi | 811950 |
KEGGi | pfa:PF3D7_1438900 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1438900 |
Phylogenomic databases
HOGENOMi | CLU_042529_21_1_1 |
OMAi | FWYPKDF |
Enzyme and pathway databases
Reactomei | R-PFA-3299685, Detoxification of Reactive Oxygen Species R-PFA-5628897, TP53 Regulates Metabolic Genes R-PFA-6798695, Neutrophil degranulation |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IL80_PLAF7 | |
Accessioni | Q8IL80Primary (citable) accession number: Q8IL80 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |