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Entry version 123 (31 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

M17 leucyl aminopeptidase

Gene

PF3D7_1446200

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi374Zinc 1Combined sources1
Metal bindingi379MagnesiumCombined sources1
Metal bindingi379Zinc 1Combined sources1
Metal bindingi379Zinc 2Combined sources1
Metal bindingi379Zinc 3Combined sources1
Metal bindingi399Zinc 1Combined sources1
Metal bindingi459MagnesiumCombined sources1
Metal bindingi459Zinc 2Combined sources1
Metal bindingi459Zinc 3Combined sources1
Metal bindingi459Zinc 4Combined sources1
Metal bindingi461MagnesiumCombined sources1
Metal bindingi461Zinc 1Combined sources1
Metal bindingi461Zinc 2Combined sources1
Metal bindingi461Zinc 4Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidaseImported, Hydrolase, Protease
LigandMagnesiumCombined sources, Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PF14_0439-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M17.008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
M17 leucyl aminopeptidaseImported (EC:3.4.11.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1446200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1446200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1293313

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8IL11

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IL11

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15833302,EBI-15833302

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-58533N

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IL11

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini457 – 464CYTOSOL_APInterPro annotation8

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K01255

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGCAYCI

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00433 Peptidase_M17, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00181 Cytosol_peptidase_M17, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept

The PANTHER Classification System

More...
PANTHERi
PTHR11963 PTHR11963, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00883 Peptidase_M17, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00481 LAMNOPPTDASE

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IL11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYFSSLCKFL PISEKEKIYL NIVKKRFCKS NIYYNNNNNN IINYNKRGLK
60 70 80 90 100
FYPFCNNLKK NINFVNINNK KGINFHSINK ERKMASEVPQ VVSLDPTSIP
110 120 130 140 150
IEYNTPIHDI KVQVYDIKGG CNVEEGLTIF LVNNPGKENG PVKISSKVND
160 170 180 190 200
KNVSEFLKDE NMEKFNVKLG TSKHFYMFND NKNSVAVGYV GCGSVADLSE
210 220 230 240 250
ADMKRVVLSL VTMLHDNKLS KLTVVFEINV DKNLFRFFLE TLFYEYMTDE
260 270 280 290 300
RFKSTDKNVN MEYIKHLGVY INNADTYKEE VEKARVYYFG TYYASQLIAA
310 320 330 340 350
PSNYCNPVSL SNAAVELAQK LNLEYKILGV KELEELKMGA YLSVGKGSMY
360 370 380 390 400
PNKFIHLTYK SKGDVKKKIA LVGKGITFDS GGYNLKAAPG SMIDLMKFDM
410 420 430 440 450
SGCAAVLGCA YCVGTLKPEN VEIHFLSAVC ENMVSKNSYR PGDIITASNG
460 470 480 490 500
KTIEVGNTDA EGRLTLADAL VYAEKLGVDY IVDIATLTGA MLYSLGTSYA
510 520 530 540 550
GVFGNNEELI NKILNSSKTS NEPVWWLPII NEYRATLNSK YADINNISSS
560 570 580 590 600
VKASSIVASL FLKEFVQNTA WAHIDIAGVS WNFKARKPKG FGVRLLTEFV

LNDAL
Length:605
Mass (Da):67,821
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA30B9A341AB9F44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00157.1

NCBI Reference Sequences

More...
RefSeqi
XP_001348613.1, XM_001348577.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZU00157; CZU00157; PF3D7_1446200

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1446200.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812021

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1446200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00157.1
RefSeqiXP_001348613.1, XM_001348577.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KQXX-ray2.01A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
3KQZX-ray2.39A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
3KR4X-ray2.00A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
3KR5X-ray2.56A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
3T8WX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
4K3NX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
4R6TX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
4R76X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
4R7MX-ray2.85A/B/C/D/E/F/G/H/I/J/K/L84-605[»]
4X2TX-ray2.73A/B/C/D/E/F/G/H/I/J/K/L85-603[»]
SMRiQ8IL11
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-58533N

Chemistry databases

ChEMBLiCHEMBL1293313

Protein family/group databases

MEROPSiM17.008

PTM databases

SwissPalmiQ8IL11

Proteomic databases

PRIDEiQ8IL11

Genome annotation databases

EnsemblProtistsiCZU00157; CZU00157; PF3D7_1446200
GeneDBiPF3D7_1446200.1:pep
GeneIDi812021
KEGGipfa:PF3D7_1446200

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1446200

Phylogenomic databases

KOiK01255
OMAiLGCAYCI

Enzyme and pathway databases

BioCyciPLASMO:PF14_0439-MONOMER

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IL11_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IL11
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 31, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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