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Entry version 108 (18 Sep 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase

Gene

PF14_0511

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme which catalyzes the first two steps of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

G6PD activity is inhibited by glucosamine-6-phosphate, NADPH, and 4-(4-bromophenyl)-7-(3,4-dimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1 H,3H)-dione. G6PD and 6PGL activities can be reversibly inhibited by S-glutathionylation (in vitro).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=19.2 µM for glucose-6-phosphate (at 25 degrees Celsius)1 Publication
  2. KM=6.5 µM for NADP+ (at 25 degrees Celsius)1 Publication
  3. KM=172 µM for 6-phosphoglucono-gamma-lactone (at 25 degrees Celsius)1 Publication
  1. Vmax=5.2 µmol/min/mg enzyme towards glucose-6-phosphate (at 25 degrees Celsius)1 Publication
  2. Vmax=4.6 µmol/min/mg enzyme towards NADP+ (at 25 degrees Celsius)1 Publication
  3. Vmax=46.6 µmol/min/mg enzyme with 6-phosphoglucono-gamma-lactone as substrate (at 25 degrees Celsius)1 Publication

pH dependencei

Optimum pH is 8.0 for G6PD activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).1 Publication
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase (PF14_0511)
  2. Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase (PF14_0511)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (PF3D7_1454700)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei379NADPBy similarity1
Binding sitei548NADP; via carbonyl oxygenBy similarity1
Binding sitei548SubstrateBy similarity1
Binding sitei616SubstrateBy similarity1
Binding sitei635SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei640Proton acceptor; for G6PD activityBy similarity1
Binding sitei745SubstrateBy similarity1
Binding sitei779SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi345 – 352NADPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Oxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PF14_0511-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-5628897 TP53 Regulates Metabolic Genes
R-PFA-71336 Pentose phosphate pathway

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00115;UER00408
UPA00115;UER00409

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase1 Publication
Short name:
PfGluPho1 Publication
Including the following 2 domains:
6-phosphogluconolactonase1 Publication (EC:3.1.1.311 Publication)
Short name:
6PGL1 Publication
Glucose-6-phosphate 1-dehydrogenase1 Publication (EC:1.1.1.491 Publication)
Short name:
G6PD1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF14_0511
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1453800

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004245581 – 910Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonaseAdd BLAST910

Keywords - PTMi

Glutathionylation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8IKU0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IKU0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1706-phosphogluconolactonaseSequence analysisAdd BLAST170
Regioni171 – 276LinkerSequence analysisAdd BLAST106
Regioni277 – 910Glucose-6-phosphate 1-dehydrogenaseSequence analysisAdd BLAST634
Regioni578 – 582Substrate bindingBy similarity5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.Sequence analysis
In the C-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.Sequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000282031

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IKU0

KEGG Orthology (KO)

More...
KOi
K00036

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYNNEFV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IKU0

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00966 G6PD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001282 G6P_DH
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR006148 Glc/Gal-6P_isomerase
IPR036291 NAD(P)-bd_dom_sf
IPR037171 NagB/RpiA_transferase-like

The PANTHER Classification System

More...
PANTHERi
PTHR23429 PTHR23429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PF01182 Glucosamine_iso, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00079 G6PDHDRGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 1 hit
SSF51735 SSF51735, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IKU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYENFVKSA EEINNLHNVN YLETKDLNDF NWKAAYYICK EIYDKQQINK
60 70 80 90 100
DGYVVIGLSG GRTPIDVYKN MCLIKDIKID KSKLIFFIID ERYKSDDHKF
110 120 130 140 150
SNYNNIKFLF HNLNINEKEQ LYKPDTTKSI VDCILDYNDK IKIMIEKYKK
160 170 180 190 200
VDIAILGMGS DFHIASLFPN IFYNIYMNNY QNNYIYNEKT LDFINNDQDN
210 220 230 240 250
DNLKYLKEYV YFTTTNQFDV RKRITVSLNL LANASSKIFL LNSKDKLDLW
260 270 280 290 300
KNMLIKSYIE VNYNLYPATY LIDTSCTNEN VNINNNNNNN NKNKNNYCYS
310 320 330 340 350
NTTVISCGYE NYTKSIEEIY DSKYALSLYS NSLNKEELLT IIIFGCSGDL
360 370 380 390 400
AKKKIYPALF KLFCNNSLPK DLLIIGFART VQDFDTFFDK IVIYLKRCLL
410 420 430 440 450
CYEDWSISKK KDLLNGFKNR CRYFVGNYSS SESFENFNKY LTTIEEEEAK
460 470 480 490 500
KKYYATCYKM NGSDYNISNN VAEDNISIDD ENKTNEYFQM CTPKNCPDNV
510 520 530 540 550
FSSNYNFPYV INRMLYLALP PHIFVSTLKN YKKNCLNSKG TDKILLEKPF
560 570 580 590 600
GNDLDSFKML SKQILENFNE QQIYRIDHYL GKDMVSGLLK LKFTNTFLLS
610 620 630 640 650
LMNRHFIKCI KITLKETKGV YGRGQYFDPY GIIRDVMQNH MLQLLTLITM
660 670 680 690 700
EDPIDLNDES VKNEKIKILK SIPSIKLEDT IIGQYEKAEN FKEDENNDDE
710 720 730 740 750
SKKNHSYHDD PHIDKNSITP TFCTCILYIN SINWYGVPII FKSGKGLNKD
760 770 780 790 800
ICEIRIQFHN IMGSSDENMN NNEFVIILQP VEAIYLKMMI KKTGCEEMEE
810 820 830 840 850
VQLNLTVNEK NKKINVPEAY ETLLLECFKG HKKKFISDEE LYESWRIFTP
860 870 880 890 900
LLKELQEKQV KPLKYSFGSS GPKEVFGLVK KYYNYGKNYT HRPEFVRKSS
910
FYEDDLLDIN
Length:910
Mass (Da):106,987
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00BF883431E018A4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN37124.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S40259
S47533

NCBI Reference Sequences

More...
RefSeqi
XP_001348685.1, XM_001348649.2

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1453800.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1453800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN37124.1
PIRiS40259
S47533
RefSeqiXP_001348685.1, XM_001348649.2

3D structure databases

SMRiQ8IKU0
ModBaseiSearch...

Proteomic databases

PRIDEiQ8IKU0

Genome annotation databases

GeneDBiPF3D7_1453800.1:pep
GeneIDi812093
KEGGipfa:PF3D7_1453800

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1453800

Phylogenomic databases

HOGENOMiHOG000282031
InParanoidiQ8IKU0
KOiK00036
OMAiMYNNEFV
PhylomeDBiQ8IKU0

Enzyme and pathway databases

UniPathwayiUPA00115;UER00408
UPA00115;UER00409
BioCyciPLASMO:PF14_0511-MONOMER
ReactomeiR-PFA-5628897 TP53 Regulates Metabolic Genes
R-PFA-71336 Pentose phosphate pathway

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR006148 Glc/Gal-6P_isomerase
IPR036291 NAD(P)-bd_dom_sf
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PF01182 Glucosamine_iso, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF100950 SSF100950, 1 hit
SSF51735 SSF51735, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLUPH_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IKU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2013
Last sequence update: March 1, 2003
Last modified: September 18, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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