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Entry version 95 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

GTP-binding protein, putative

Gene

PF3D7_1462300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GTP-binding protein, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1462300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_1462300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1155 – 1178HelicalSequence analysisAdd BLAST24
Transmembranei1185 – 1204HelicalSequence analysisAdd BLAST20
Transmembranei1224 – 1246HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501920764919 – 1357Sequence analysisAdd BLAST1339

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8IKL1

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IKL1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 216GBPInterPro annotationAdd BLAST79
Domaini274 – 400GBPInterPro annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 65DisorderedSequence analysisAdd BLAST33
Regioni552 – 586DisorderedSequence analysisAdd BLAST35
Regioni1326 – 1357DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili237 – 257Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi552 – 566Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi567 – 586Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_263119_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYKDEIC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IKL1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015894, Guanylate-bd_N
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02263, GBP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IKL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKLFFLCFL VIIIYSLSIY YCNDNILENA NNDDSTKDIN NINKNSSNKS
60 70 80 90 100
KSEKTSNYNN DQYNIDDAYN EDEENDEEEG DDDENDHFEV PINCSGGNCF
110 120 130 140 150
DSMDDINKII DNKKKKMKYR RRRGKAIQII KPNVNHTELI IIEENLEIFK
160 170 180 190 200
RIDKPIAIVS VLGDMHTGKS FLLNLLNEHV IPDINKSNKY IENGFKVGND
210 220 230 240 250
ITASTYGIWI WSEPIRINVK KLKKIYEYIN ENFTNFIKSY EYEKDEYNEE
260 270 280 290 300
IIDLLNLYKT DDWISNVEEL NLSDTDEVNL ILMDTQGLNS PNVNKRYDEI
310 320 330 340 350
LYALTNLIST DIIFLTMKMI NNKDLEFIEN ITKDANLFML RAYTRSSGST
360 370 380 390 400
FSIKKNNFHK ILDTLNNNLE NNSLILESIA SKNLMWVVHD FSQRLDVRKG
410 420 430 440 450
KLWLDILLNS DRRDLDIKYW KKIISNKSKD KHDAYTTKKQ KIAYLTYNEN
460 470 480 490 500
SSSGLLPNNN NNNNNSNDSS SNYKLNILYK NIDCVLLRNM YHNKEFDFTK
510 520 530 540 550
ANINDLNEEY KNDVLLLRYK IYLRALLFPK KMYSDVQINN IINKIRKEQK
560 570 580 590 600
LREEQEKNKD NKKNDTNNQT NDLNSNKDET SGSQVTNRFM SGHDVYDFIT
610 620 630 640 650
FLVKSANQNL FTNVNQFFKH FKINRAEISR NDLIFLYKKY LLQFMENEDV
660 670 680 690 700
EFISNLNDEN DDLFLQKEGN NTSVNHDENS DADSLFNDHD ENMQLKEHNI
710 720 730 740 750
KDGEDNTHQK KDSYKLPPLL NEIKKYEELI REQILNIWYK YTESDFHDEE
760 770 780 790 800
EKELIKDIEN NLYERLDQIK IEMLELGEMN IRKFCKIACE DALQIVVEDI
810 820 830 840 850
KMKSDQYPIK QKDLTTFFES VSYNLIKYLE KKLSKNSDKL DLIYYKDNIC
860 870 880 890 900
SPLINNTFQE FYFLKKKNIT LNENRLKSYF SNAVEKGKEV FEVLAENTEN
910 920 930 940 950
ITEYFKNKNM FYTVLDKWTS EAINTYTLTL SDFAKEEKEI NDEYLNVLNN
960 970 980 990 1000
DIKLLKQKAM EKWHNHCRDK TSALYNMHKS NLKKNFLENF NFPLDELVLQ
1010 1020 1030 1040 1050
DIFLNLKGQE ELKYMDIYCA NEDSWNSEYK NFLKLTDEIF QFIKDENLKA
1060 1070 1080 1090 1100
IQITCQQPLD ELKNGIKGEI HKYYLWSSLK STLYNRALIV LSSNIENIYI
1110 1120 1130 1140 1150
KNQRENKIQS NLDEKYNNKN KNYKRISKDL MSKVINRWLN NDIYNVYYPI
1160 1170 1180 1190 1200
IRKQFLHRIV CYLGIAILIF IISLVVYFKK FHASFLFLII LALFMVFGYQ
1210 1220 1230 1240 1250
QISIYGKTFF RHVVFYMYEG IANVFGTEGA IIVSILFISV TAIYVYNYHI
1260 1270 1280 1290 1300
VKFKKRVAKN TKKLLQSQNI MNMSGQNPYN DYNPSSKMRI FKPNFWRFQD
1310 1320 1330 1340 1350
YDKDPKYHAP NIPHDYKMHN DSSQYMDLKN RSNRPNEMDD YTSFNNSSKF

QRRSYLD
Length:1,357
Mass (Da):161,219
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA600959E38D18F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00320.1

NCBI Reference Sequences

More...
RefSeqi
XP_001348767.1, XM_001348731.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZU00320; CZU00320; PF3D7_1462300

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1462300.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1462300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00320.1
RefSeqiXP_001348767.1, XM_001348731.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiQ8IKL1

Proteomic databases

PRIDEiQ8IKL1

Genome annotation databases

EnsemblProtistsiCZU00320; CZU00320; PF3D7_1462300
GeneDBiPF3D7_1462300.1:pep
GeneIDi812175
KEGGipfa:PF3D7_1462300

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1462300

Phylogenomic databases

HOGENOMiCLU_263119_0_0_1
OMAiYYKDEIC
PhylomeDBiQ8IKL1

Family and domain databases

InterProiView protein in InterPro
IPR015894, Guanylate-bd_N
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF02263, GBP, 2 hits
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IKL1_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IKL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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