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UniProtKB - Q8IKG4 (DXR_PLAF7)

Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

Gene

DXR

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).By similarity

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 divalent cation per subunit. Mg2+ or Mn2+.By similarity

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (DXR)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ISPF)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136NADPBy similarity1
Binding sitei205SubstrateBy similarity1
Binding sitei206NADPBy similarity1
Metal bindingi231Divalent metal cationBy similarity1
Binding sitei232SubstrateBy similarity1
Metal bindingi233Divalent metal cationBy similarity1
Binding sitei293SubstrateBy similarity1
Metal bindingi315Divalent metal cationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 89NADPBy similarity6
Nucleotide bindingi113 – 117NADPBy similarity5

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandMagnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.1.1.267 4889
UniPathwayi
UPA00056;UER00092

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (EC:1.1.1.267)
Short name:
1-deoxyxylulose-5-phosphate reductoisomerase
Short name:
DOXP reductoisomerase
Short name:
DXP reductoisomerase
Gene namesi
Name:DXR
ORF Names:PF14_0641
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1467300

Subcellular locationi

GO - Cellular componenti

  • apicoplast Source: GeneDB
View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Apicoplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 72ApicoplastBy similarityAdd BLAST72
ChainiPRO_000041560973 – 4881-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplasticAdd BLAST416

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

Secondary structure

1488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IKG4
SMRiQ8IKG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni269 – 270Binding to substrate phosphate groupBy similarity2
Regioni311 – 315Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the DXR family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000007220
InParanoidiQ8IKG4
KOiK00099
OMAiDSEHFGL
PhylomeDBiQ8IKG4

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IKG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKYIYIYFF FITITINDLV INNTSKCVSI ERRKNNAYIN YGIGYNGPDN 
        60         70         80         90        100
KITKSRRCKR IKLCKKDLID IGAIKKPINV AIFGSTGSIG TNALNIIREC 
       110        120        130        140        150
NKIENVFNVK ALYVNKSVNE LYEQAREFLP EYLCIHDKSV YEELKELVKN 
       160        170        180        190        200
IKDYKPIILC GDEGMKEICS SNSIDKIVIG IDSFQGLYST MYAIMNNKIV 
       210        220        230        240        250
ALANKESIVS AGFFLKKLLN IHKNAKIIPV DSEHSAIFQC LDNNKVLKTK 
       260        270        280        290        300
CLQDNFSKIN NINKIFLCSS GGPFQNLTMD ELKNVTSENA LKHPKWKMGK 
       310        320        330        340        350
KITIDSATMM NKGLEVIETH FLFDVDYNDI EVIVHKECII HSCVEFIDKS 
       360        370        380        390        400
VISQMYYPDM QIPILYSLTW PDRIKTNLKP LDLAQVSTLT FHKPSLEHFP 
       410        420        430        440        450
CIKLAYQAGI KGNFYPTVLN ASNEIANNLF LNNKIKYFDI SSIISQVLES 
       460        470        480 
FNSQKVSENS EDLMKQILQI HSWAKDKATD IYNKHNSS
Length:488
Mass (Da):55,757
Last modified:March 1, 2003 - v1
Checksum:i4E280C81CDFAD3EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN37254.1
RefSeqiXP_001348815.1, XM_001348779.1

Genome annotation databases

GeneDBiPF3D7_1467300.1:pep
GeneIDi812223
KEGGipfa:PF3D7_1467300

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN37254.1
RefSeqiXP_001348815.1, XM_001348779.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y67X-ray1.60A/B75-488[»]
4Y6PX-ray1.90A/B75-488[»]
4Y6RX-ray1.90A/B75-488[»]
4Y6SX-ray2.10A/B75-488[»]
5JAZX-ray1.40A/B75-488[»]
5JBIX-ray1.70A/B75-488[»]
5JC1X-ray1.65A/B75-488[»]
5JMPX-ray1.70A/B75-488[»]
5JMWX-ray1.55A/B75-488[»]
5JNLX-ray1.60A/B75-488[»]
5JO0X-ray1.80A/B75-488[»]
ProteinModelPortaliQ8IKG4
SMRiQ8IKG4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiPF3D7_1467300.1:pep
GeneIDi812223
KEGGipfa:PF3D7_1467300

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1467300

Phylogenomic databases

HOGENOMiHOG000007220
InParanoidiQ8IKG4
KOiK00099
OMAiDSEHFGL
PhylomeDBiQ8IKG4

Enzyme and pathway databases

UniPathwayi
UPA00056;UER00092

BRENDAi1.1.1.267 4889

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDXR_PLAF7
AccessioniPrimary (citable) accession number: Q8IKG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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