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UniProtKB - Q8IKG4 (DXR_PLAF7)
Protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Gene
DXR
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
2 PublicationsCatalytic activityi
- 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH2 PublicationsEC:1.1.1.2672 PublicationsThis reaction proceeds in the backward2 Publications direction.
Cofactori
Mg2+By similarity, Mn2+2 PublicationsNote: Binds 1 divalent cation per subunit. Mg2+ or Mn2+.2 Publications
Activity regulationi
Inhibited by fosmidomycin and its derivatives.2 Publications
: isopentenyl diphosphate biosynthesis via DXP pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.2 Publications This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 205 | 1-deoxy-D-xylulose 5-phosphateBy similarity | 1 | |
Binding sitei | 206 | NADPBy similarity | 1 | |
Metal bindingi | 231 | Divalent metal cationCombined sources2 Publications | 1 | |
Metal bindingi | 233 | Divalent metal cationCombined sources2 Publications | 1 | |
Binding sitei | 233 | 1-deoxy-D-xylulose 5-phosphateBy similarity | 1 | |
Binding sitei | 270 | 1-deoxy-D-xylulose 5-phosphateBy similarity | 1 | |
Binding sitei | 293 | 1-deoxy-D-xylulose 5-phosphateBy similarity | 1 | |
Binding sitei | 299 | NADP; via amide nitrogenBy similarity | 1 | |
Metal bindingi | 315 | Divalent metal cationCombined sources2 Publications | 1 | |
Binding sitei | 315 | 1-deoxy-D-xylulose 5-phosphateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 86 – 89 | NADPBy similarity | 4 | |
Nucleotide bindingi | 115 – 117 | NADPBy similarity | 3 |
GO - Molecular functioni
- 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: GO_Central
- manganese ion binding Source: GO_Central
- NADPH binding Source: GO_Central
GO - Biological processi
- isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Isoprene biosynthesis |
Ligand | Magnesium, Manganese, Metal-binding, NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.267, 4889 |
UniPathwayi | UPA00056;UER00092 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (EC:1.1.1.2672 Publications)Short name: 1-deoxyxylulose-5-phosphate reductoisomerase Short name: DOXP reductoisomerase Short name: DXP reductoisomerase |
Gene namesi | Name:DXR ORF Names:PF14_0641, PF3D7_1467300 |
Organismi | Plasmodium falciparum (isolate 3D7) |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1467300 |
Subcellular locationi
Other locations
- apicoplast By similarity
Other locations
- apicoplast Source: GeneDB
Keywords - Cellular componenti
Apicoplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 72 | ApicoplastCuratedAdd BLAST | 72 | |
ChainiPRO_0000415609 | 73 – 488 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplasticAdd BLAST | 416 |
Proteomic databases
PRIDEi | Q8IKG4 |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsProtein-protein interaction databases
STRINGi | 5833.PF14_0641 |
Chemistry databases
BindingDBi | Q8IKG4 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IKG4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 306 – 312 | Binding to substrate phosphate groupBy similarity | 7 |
Sequence similaritiesi
Belongs to the DXR family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
HOGENOMi | CLU_035714_4_0_1 |
InParanoidi | Q8IKG4 |
OMAi | PIDSEHF |
PhylomeDBi | Q8IKG4 |
Family and domain databases
HAMAPi | MF_00183, DXP_reductoisom, 1 hit |
InterProi | View protein in InterPro IPR003821, DXP_reductoisomerase IPR013644, DXP_reductoisomerase_C IPR013512, DXP_reductoisomerase_N IPR026877, DXPR_C IPR036169, DXPR_C_sf IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR30525, PTHR30525, 1 hit |
Pfami | View protein in Pfam PF08436, DXP_redisom_C, 1 hit PF02670, DXP_reductoisom, 1 hit PF13288, DXPR_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF69055, SSF69055, 1 hit |
TIGRFAMsi | TIGR00243, Dxr, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8IKG4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKYIYIYFF FITITINDLV INNTSKCVSI ERRKNNAYIN YGIGYNGPDN
60 70 80 90 100
KITKSRRCKR IKLCKKDLID IGAIKKPINV AIFGSTGSIG TNALNIIREC
110 120 130 140 150
NKIENVFNVK ALYVNKSVNE LYEQAREFLP EYLCIHDKSV YEELKELVKN
160 170 180 190 200
IKDYKPIILC GDEGMKEICS SNSIDKIVIG IDSFQGLYST MYAIMNNKIV
210 220 230 240 250
ALANKESIVS AGFFLKKLLN IHKNAKIIPV DSEHSAIFQC LDNNKVLKTK
260 270 280 290 300
CLQDNFSKIN NINKIFLCSS GGPFQNLTMD ELKNVTSENA LKHPKWKMGK
310 320 330 340 350
KITIDSATMM NKGLEVIETH FLFDVDYNDI EVIVHKECII HSCVEFIDKS
360 370 380 390 400
VISQMYYPDM QIPILYSLTW PDRIKTNLKP LDLAQVSTLT FHKPSLEHFP
410 420 430 440 450
CIKLAYQAGI KGNFYPTVLN ASNEIANNLF LNNKIKYFDI SSIISQVLES
460 470 480
FNSQKVSENS EDLMKQILQI HSWAKDKATD IYNKHNSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZU00370.1 |
RefSeqi | XP_001348815.1, XM_001348779.1 |
Genome annotation databases
EnsemblProtistsi | CZU00370; CZU00370; PF3D7_1467300 |
GeneIDi | 812223 |
KEGGi | pfa:PF3D7_1467300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999946 Genomic DNA Translation: CZU00370.1 |
RefSeqi | XP_001348815.1, XM_001348779.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Y67 | X-ray | 1.60 | A/B | 75-488 | [»] | |
4Y6P | X-ray | 1.90 | A/B | 75-488 | [»] | |
4Y6R | X-ray | 1.90 | A/B | 75-488 | [»] | |
4Y6S | X-ray | 2.10 | A/B | 75-488 | [»] | |
5JAZ | X-ray | 1.40 | A/B | 75-488 | [»] | |
5JBI | X-ray | 1.70 | A/B | 75-488 | [»] | |
5JC1 | X-ray | 1.65 | A/B | 75-488 | [»] | |
5JMP | X-ray | 1.70 | A/B | 75-488 | [»] | |
5JMW | X-ray | 1.55 | A/B | 75-488 | [»] | |
5JNL | X-ray | 1.60 | A/B | 75-488 | [»] | |
5JO0 | X-ray | 1.80 | A/B | 75-488 | [»] | |
SMRi | Q8IKG4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 5833.PF14_0641 |
Chemistry databases
BindingDBi | Q8IKG4 |
ChEMBLi | CHEMBL4295619 |
Proteomic databases
PRIDEi | Q8IKG4 |
Genome annotation databases
EnsemblProtistsi | CZU00370; CZU00370; PF3D7_1467300 |
GeneIDi | 812223 |
KEGGi | pfa:PF3D7_1467300 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1467300 |
Phylogenomic databases
HOGENOMi | CLU_035714_4_0_1 |
InParanoidi | Q8IKG4 |
OMAi | PIDSEHF |
PhylomeDBi | Q8IKG4 |
Enzyme and pathway databases
UniPathwayi | UPA00056;UER00092 |
BRENDAi | 1.1.1.267, 4889 |
Family and domain databases
HAMAPi | MF_00183, DXP_reductoisom, 1 hit |
InterProi | View protein in InterPro IPR003821, DXP_reductoisomerase IPR013644, DXP_reductoisomerase_C IPR013512, DXP_reductoisomerase_N IPR026877, DXPR_C IPR036169, DXPR_C_sf IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR30525, PTHR30525, 1 hit |
Pfami | View protein in Pfam PF08436, DXP_redisom_C, 1 hit PF02670, DXP_reductoisom, 1 hit PF13288, DXPR_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF69055, SSF69055, 1 hit |
TIGRFAMsi | TIGR00243, Dxr, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DXR_PLAF7 | |
Accessioni | Q8IKG4Primary (citable) accession number: Q8IKG4 Secondary accession number(s): A0A144A2T4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families