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Entry version 137 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Methionine aminopeptidase 1b

Gene

METAP1b

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins (PubMed:16983082, PubMed:27023914).

The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity).

May play an important role in parasite growth during the blood asexual stage (PubMed:16983082).

UniRule annotation2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Co2+UniRule annotation1 Publication, Zn2+UniRule annotation1 Publication, Mn2+UniRule annotation1 Publication, Fe2+UniRule annotation1 PublicationNote: Highest activity with zinc and cobalt ions, and low activity with manganese or divalent iron ions (PubMed:27023914). Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site (By similarity).UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by pyrimidine derivative XC11.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 13.9 min(-1) with methionine containing-oligopeptide as substrate (PubMed:16983082). kcat is 552.49 min(-1) in presence of 1 µM Zn2+, 442.48 min(-1) in presence of 10 µM Zn2+ and 364.30 min(-1) in presence of 100 µM Zn2+, with Met-Gly-Met-Met peptide as substrate (PubMed:27023914). kcat is 1005 min(-1) in presence of 1 µM Co2+, 583.09 min(-1) in presence of 10 µM Co2+ and 547.95 min(-1) in presence of 100 µM Co2+, with Met-Gly-Met-Met peptide as substrate (PubMed:27023914).2 Publications
  1. KM=327.3 µM for methionine containing-oligopeptide1 Publication
  2. KM=845.08 µM for Met-Gly-Met-Met peptide (in presence of 1 µM Zn2+, at 37 degrees Celsius, pH 7.5)1 Publication
  3. KM=1117.7 µM for Met-Gly-Met-Met peptide (in presence of 10 µM Zn2+, at 37 degrees Celsius, pH 7.5)1 Publication
  4. KM=1662.4 µM for Met-Gly-Met-Met peptide (in presence of 100 µM Zn2+, at 37 degrees Celsius, pH 7.5)1 Publication
  5. KM=1759 µM for Met-Gly-Met-Met peptide (in presence of 1 µM Co2+, at 37 degrees Celsius, pH 7.5)1 Publication
  6. KM=1142.4 µM for Met-Gly-Met-Met peptide (in presence of 10 µM Co2+, at 37 degrees Celsius, pH 7.5)1 Publication
  7. KM=1061.5 µM for Met-Gly-Met-Met peptide (in presence of 100 µM Co2+, at 37 degrees Celsius, pH 7.5)1 Publication

    pH dependencei

    Optimum pH is 7.5.1 Publication

    Temperature dependencei

    Optimum temperature is 37 degrees Celsius (PubMed:27023914). However, has substantial activity at 25 degrees Celsius (PubMed:27023914).1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei316Important for substrate specificity to methionine1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei325SubstrateUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi342Divalent metal cation 1UniRule annotation1
    Metal bindingi353Divalent metal cation 1UniRule annotation1
    Metal bindingi353Divalent metal cation 2; catalyticUniRule annotationCombined sources1
    Metal bindingi419Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotationCombined sources1
    Binding sitei426SubstrateUniRule annotation1
    Metal bindingi452Divalent metal cation 2; catalyticUniRule annotationCombined sources1
    Metal bindingi483Divalent metal cation 1UniRule annotation1
    Metal bindingi483Divalent metal cation 2; catalyticUniRule annotationCombined sources1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Protease
    LigandMetal-binding

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M24.017

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Methionine aminopeptidase 1b1 Publication (EC:3.4.11.18UniRule annotation2 Publications)
    Alternative name(s):
    PfMetAP1b1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:METAP1b1 Publication
    ORF Names:PF3D7_1015300Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    PlasmoDB:PF3D7_1015300

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi316C → S: 50% reduction in activity with Zn(2+) as cofactor. Increases activity with Co(2+) as cofactor and acquires new substrate specificity to leucine, tryptophan and phenylalanine. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004511901 – 517Methionine aminopeptidase 1bAdd BLAST517

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8IJP2

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q8IJP2, 2 interactors

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1517
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8IJP2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 94DisorderedSequence analysisAdd BLAST21

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi76 – 94Polar residuesSequence analysisAdd BLAST19

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_015857_2_0_1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SKMYVMP

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01086, MetAP1, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.230.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01974, MetAP_1, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036005, Creatinase/aminopeptidase-like
    IPR000994, Pept_M24
    IPR001714, Pept_M24_MAP
    IPR002467, Pept_M24A_MAP1
    IPR031615, Zfn-C6H2

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00557, Peptidase_M24, 1 hit
    PF15801, zf-C6H2, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00599, MAPEPTIDASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55920, SSF55920, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00500, met_pdase_I, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00680, MAP_1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8IJP2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MANIDDIEKQ IENIKINSDD NKNNVSKNKN ILLNGVNLKD HEIKDNVKSV
    60 70 80 90 100
    DYNNNNNEND TMNEINKHVK NDEYCNKENS NNNNNNNNNN NNNLDTQINE
    110 120 130 140 150
    TLNLNEKFEK KNEENLCSGC KKVLIKKLSC PICLKNKIFS YFCNQECFKG
    160 170 180 190 200
    SWKEHQKIHE NMNKENNEKE DHLKTIVKKH LSPENFDPTN RKYWVYDDHL
    210 220 230 240 250
    KNFVNFKFTG DVRPWPLSKI NHVPSHIERP DYAISSIPES ELIYKRKSDI
    260 270 280 290 300
    YVNNEEEIQR IREACILGRK TLDYAHTLVS PGVTTDEIDR KVHEFIIKNN
    310 320 330 340 350
    AYPSTLNYYK FPKSCCTSVN EIVCHGIPDY RPLKSGDIIN IDISVFYKGV
    360 370 380 390 400
    HSDLNETYFV GDINDVPKEG KELVETCYFS LMEAIKKCKP GMFYKNIGTL
    410 420 430 440 450
    IDAYVSKKNF SVVRSYSGHG VGKLFHSNPT VPHFKKNKAV GIMKPGHVFT
    460 470 480 490 500
    IEPMINQGHY SDVLWPDQWT SATSDGKLSA QFEHTLLITN NGVEILTKRT
    510
    QDSPPLGFDT KDELYYN
    Length:517
    Mass (Da):59,724
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD216A8F8D25E7AF
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    LN999944 Genomic DNA Translation: CZT98405.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_001347435.1, XM_001347399.1

    Genome annotation databases

    Ensembl protists genome annotation project

    More...
    EnsemblProtistsi
    CZT98405; CZT98405; PF3D7_1015300

    GeneDB pathogen genome database from Sanger Institute

    More...
    GeneDBi
    PF3D7_1015300.1:pep

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    810308

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    pfa:PF3D7_1015300

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    LN999944 Genomic DNA Translation: CZT98405.1
    RefSeqiXP_001347435.1, XM_001347399.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3S6BX-ray1.95A168-517[»]
    SMRiQ8IJP2
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    IntActiQ8IJP2, 2 interactors

    Protein family/group databases

    MEROPSiM24.017

    Proteomic databases

    PRIDEiQ8IJP2

    Genome annotation databases

    EnsemblProtistsiCZT98405; CZT98405; PF3D7_1015300
    GeneDBiPF3D7_1015300.1:pep
    GeneIDi810308
    KEGGipfa:PF3D7_1015300

    Organism-specific databases

    VEuPathDBiPlasmoDB:PF3D7_1015300

    Phylogenomic databases

    HOGENOMiCLU_015857_2_0_1
    OMAiSKMYVMP

    Family and domain databases

    CDDicd01086, MetAP1, 1 hit
    Gene3Di3.90.230.10, 1 hit
    HAMAPiMF_01974, MetAP_1, 1 hit
    InterProiView protein in InterPro
    IPR036005, Creatinase/aminopeptidase-like
    IPR000994, Pept_M24
    IPR001714, Pept_M24_MAP
    IPR002467, Pept_M24A_MAP1
    IPR031615, Zfn-C6H2
    PfamiView protein in Pfam
    PF00557, Peptidase_M24, 1 hit
    PF15801, zf-C6H2, 1 hit
    PRINTSiPR00599, MAPEPTIDASE
    SUPFAMiSSF55920, SSF55920, 1 hit
    TIGRFAMsiTIGR00500, met_pdase_I, 1 hit
    PROSITEiView protein in PROSITE
    PS00680, MAP_1, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP1B_PLAF7
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IJP2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 7, 2020
    Last sequence update: March 1, 2003
    Last modified: June 2, 2021
    This is version 137 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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