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Protein

DNA repair protein RAD51 homolog

Gene

PF3D7_1107400

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: GeneDB
  • damaged DNA binding Source: GeneDB
  • DNA binding Source: GeneDB
  • DNA-dependent ATPase activity Source: GeneDB
  • double-stranded DNA binding Source: GO_Central
  • four-way junction DNA binding Source: GO_Central
  • recombinase activity Source: GeneDB
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homologUniRule annotation
Gene namesi
ORF Names:PF3D7_1107400Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1107400

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8IIS8

Structurei

3D structure databases

SMRiQ8IIS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.UniRule annotation

Phylogenomic databases

KOiK04482
OMAiYNTDHQT

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IIS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQANTKEDK SQKISNSSTI DEIEEEQLYT GPLKIEQLLA KGFVKRDLEL
60 70 80 90 100
LKEGGLQTVE CVAYAPMRTL CAIKGISEQK AEKLKKACKE LCNSGFCNAI
110 120 130 140 150
DYHDARQNLI KFTTGSKQLD ALLKGGIETG GITELFGEFR TGKSQLCHTL
160 170 180 190 200
AITCQLPIEQ SGGEGKCLWI DTEGTFRPER IVAIAKRYGL HPTDCLNNIA
210 220 230 240 250
YAKAYNCDHQ TELLIDASAM MADARFALLI VDSATALYRS EYIGRGELAN
260 270 280 290 300
RQSHLCRFLR GLQRIADIYG VAVIITNQVV AKVDAMSMFG GHEKIPIGGN
310 320 330 340 350
IIAHASQTRL YLRKGRGESR ICKIYDSPVL PEGEAVFAIT EGGIADYEEK
Length:350
Mass (Da):38,592
Last modified:September 22, 2009 - v2
Checksum:i5BA0988628B164CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98740.1
RefSeqiXP_001347762.2, XM_001347726.2

Genome annotation databases

EnsemblProtistsiCZT98740; CZT98740; PF3D7_1107400
GeneDBiPF3D7_1107400.1:pep
GeneIDi810638
KEGGipfa:PF3D7_1107400

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98740.1
RefSeqiXP_001347762.2, XM_001347726.2

3D structure databases

SMRiQ8IIS8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8IIS8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZT98740; CZT98740; PF3D7_1107400
GeneDBiPF3D7_1107400.1:pep
GeneIDi810638
KEGGipfa:PF3D7_1107400

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1107400

Phylogenomic databases

KOiK04482
OMAiYNTDHQT

Enzyme and pathway databases

ReactomeiR-PFA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02239 recomb_RAD51, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
PS50163 RECA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IIS8_PLAF7
AccessioniPrimary (citable) accession number: Q8IIS8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: September 22, 2009
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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