UniProtKB - Q8IIS8 (Q8IIS8_PLAF7)
Protein
DNA repair protein RAD51 homolog
Gene
PF3D7_1107400
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.UniRule annotation
GO - Molecular functioni
- ATP binding Source: GeneDB
- damaged DNA binding Source: GeneDB
- DNA binding Source: GeneDB
- DNA-dependent ATPase activity Source: GeneDB
- double-stranded DNA binding Source: GO_Central
- recombinase activity Source: GeneDB
- single-stranded DNA binding Source: GO_Central
GO - Biological processi
- chromosome organization involved in meiotic cell cycle Source: GO_Central
- DNA recombinase assembly Source: GO_Central
- DNA recombination Source: GeneDB
- DNA repair Source: GeneDB
- mitotic recombination Source: GO_Central
- mitotic recombination-dependent replication fork processing Source: InterPro
- reciprocal meiotic recombination Source: GO_Central
- response to ionizing radiation Source: GO_Central
- strand invasion Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Biological process | DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: DNA repair protein RAD51 homologUniRule annotation |
Gene namesi | ORF Names:PF3D7_1107400Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1107400 |
Subcellular locationi
- Nucleus UniRule annotation
GO - Cellular componenti
- condensed nuclear chromosome Source: GO_Central
- nucleus Source: GeneDB
Keywords - Cellular componenti
NucleusUniRule annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_041732_0_0_1 |
OMAi | GFHTIEA |
Family and domain databases
CDDi | cd01123, Rad51_DMC1_radA, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011941, DNA_recomb/repair_Rad51 IPR013632, DNA_recomb/repair_Rad51_C IPR016467, DNA_recomb/repair_RecA-like IPR010995, DNA_repair_Rad51/TF_NusA_a-hlx IPR027417, P-loop_NTPase IPR033925, Rad51_DMC1_RadA IPR020588, RecA_ATP-bd IPR020587, RecA_monomer-monomer_interface |
Pfami | View protein in Pfam PF08423, Rad51, 1 hit |
PIRSFi | PIRSF005856, Rad51, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF47794, SSF47794, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02239, recomb_RAD51, 1 hit |
PROSITEi | View protein in PROSITE PS50162, RECA_2, 1 hit PS50163, RECA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IIS8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQANTKEDK SQKISNSSTI DEIEEEQLYT GPLKIEQLLA KGFVKRDLEL
60 70 80 90 100
LKEGGLQTVE CVAYAPMRTL CAIKGISEQK AEKLKKACKE LCNSGFCNAI
110 120 130 140 150
DYHDARQNLI KFTTGSKQLD ALLKGGIETG GITELFGEFR TGKSQLCHTL
160 170 180 190 200
AITCQLPIEQ SGGEGKCLWI DTEGTFRPER IVAIAKRYGL HPTDCLNNIA
210 220 230 240 250
YAKAYNCDHQ TELLIDASAM MADARFALLI VDSATALYRS EYIGRGELAN
260 270 280 290 300
RQSHLCRFLR GLQRIADIYG VAVIITNQVV AKVDAMSMFG GHEKIPIGGN
310 320 330 340 350
IIAHASQTRL YLRKGRGESR ICKIYDSPVL PEGEAVFAIT EGGIADYEEK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999945 Genomic DNA Translation: CZT98740.1 |
RefSeqi | XP_001347762.2, XM_001347726.2 |
Genome annotation databases
EnsemblProtistsi | CZT98740; CZT98740; PF3D7_1107400 |
GeneDBi | PF3D7_1107400.1:pep |
GeneIDi | 810638 |
KEGGi | pfa:PF3D7_1107400 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999945 Genomic DNA Translation: CZT98740.1 |
RefSeqi | XP_001347762.2, XM_001347726.2 |
3D structure databases
SMRi | Q8IIS8 |
ModBasei | Search... |
PTM databases
SwissPalmi | Q8IIS8 |
Proteomic databases
PRIDEi | Q8IIS8 |
Genome annotation databases
EnsemblProtistsi | CZT98740; CZT98740; PF3D7_1107400 |
GeneDBi | PF3D7_1107400.1:pep |
GeneIDi | 810638 |
KEGGi | pfa:PF3D7_1107400 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1107400 |
Phylogenomic databases
HOGENOMi | CLU_041732_0_0_1 |
OMAi | GFHTIEA |
Family and domain databases
CDDi | cd01123, Rad51_DMC1_radA, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011941, DNA_recomb/repair_Rad51 IPR013632, DNA_recomb/repair_Rad51_C IPR016467, DNA_recomb/repair_RecA-like IPR010995, DNA_repair_Rad51/TF_NusA_a-hlx IPR027417, P-loop_NTPase IPR033925, Rad51_DMC1_RadA IPR020588, RecA_ATP-bd IPR020587, RecA_monomer-monomer_interface |
Pfami | View protein in Pfam PF08423, Rad51, 1 hit |
PIRSFi | PIRSF005856, Rad51, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF47794, SSF47794, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR02239, recomb_RAD51, 1 hit |
PROSITEi | View protein in PROSITE PS50162, RECA_2, 1 hit PS50163, RECA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IIS8_PLAF7 | |
Accessioni | Q8IIS8Primary (citable) accession number: Q8IIS8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |