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UniProtKB - Q8IIL5 (Q8IIL5_PLAF7)
Protein
Non-specific serine/threonine protein kinase
Gene
PF3D7_1114700
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 394 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- mRNA cis splicing, via spliceosome Source: InterPro
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseImportedARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | ORF Names:PF3D7_1114700Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1114700 |
Subcellular locationi
Interactioni
Protein-protein interaction databases
IntActi | Q8IIL5, 9 interactors |
STRINGi | 5833.PF11_0156 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 365 – 687 | Protein kinaseInterPro annotationAdd BLAST | 323 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 101 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 274 – 305 | DisorderedSequence analysisAdd BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 110 – 151 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 227 – 254 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 17 – 68 | Basic and acidic residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 69 – 101 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 274 – 288 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_000288_5_5_1 |
InParanoidi | Q8IIL5 |
OMAi | HERTKMN |
PhylomeDBi | Q8IIL5 |
Family and domain databases
CDDi | cd14135, STKc_PRP4, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044092, STKc_PRP4 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IIL5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKDKRNSFA SNSFDSSNDE KKSKNGNKIY KSKHEENSPD GDSYKINNNE
60 70 80 90 100
KEKSKEKLKK DQKKKSKEIY NSFNSPNSTS SDSDGNGLHL NFSNASSSSS
110 120 130 140 150
ENGFKILRTQ ENEDKLLEER RRKREALKEK LKNMVKENEQ NNDANEILQN
160 170 180 190 200
DQINKDYNNE TFLLSENKND NDIITNEIPS NPSYIDQNDA ACIFAPNNDV
210 220 230 240 250
IEDTCSSLSS DHEIIEEKQN KEKPEAVKEC SDLYNDLKKK IDEEKAKIRS
260 270 280 290 300
FIIKQKELHE RLKMNVDDSL YVNKSKGNAD THNNLTNKKS PLENEEDEMQ
310 320 330 340 350
EEYDEDNDDF DMFSCVQANK KRKVEKVHIT DYYTTGNNAN LSDNWNDSEG
360 370 380 390 400
YYKAMVGEVI DKRYSVVCEL VGKGVFSNVL KCYDMVNKIP VAVKVIRDND
410 420 430 440 450
MMKKAAEKEI SILKKLNQYD KDNKRHIIRL LSSIKYKNHL CLVFEWMWGN
460 470 480 490 500
LRIALKKYGN GHGLNATAVH CYTKQLFIAL RHMRKCRIMH ADLKPDNILI
510 520 530 540 550
NEKFNALKVC DLGSASDISE NEITSYLVSR FYRAPEIILG FRYDAQIDVW
560 570 580 590 600
SAAATVFELA TGKILFPGKS NNHMIKLMME YKGKFSHKMI KGGQFYSQHF
610 620 630 640 650
NENLDFLYVD RDHYSKKEVV RVISDLRPTK NITCDLLEHQ YWLKGNSPKM
660 670 680 690
QFLKKKIKQL GDLLEKCLIL DPSKRYTPDQ ALQHPYLRES IHFSKSQNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999945 Genomic DNA Translation: CZT98807.1 |
RefSeqi | XP_001347827.2, XM_001347791.2 |
Genome annotation databases
EnsemblProtistsi | CZT98807; CZT98807; PF3D7_1114700 |
GeneIDi | 810703 |
KEGGi | pfa:PF3D7_1114700 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999945 Genomic DNA Translation: CZT98807.1 |
RefSeqi | XP_001347827.2, XM_001347791.2 |
3D structure databases
AlphaFoldDBi | Q8IIL5 |
SMRi | Q8IIL5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8IIL5, 9 interactors |
STRINGi | 5833.PF11_0156 |
Chemistry databases
GuidetoPHARMACOLOGYi | 3105 |
Proteomic databases
PRIDEi | Q8IIL5 |
Genome annotation databases
EnsemblProtistsi | CZT98807; CZT98807; PF3D7_1114700 |
GeneIDi | 810703 |
KEGGi | pfa:PF3D7_1114700 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1114700 |
Phylogenomic databases
HOGENOMi | CLU_000288_5_5_1 |
InParanoidi | Q8IIL5 |
OMAi | HERTKMN |
PhylomeDBi | Q8IIL5 |
Family and domain databases
CDDi | cd14135, STKc_PRP4, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044092, STKc_PRP4 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IIL5_PLAF7 | |
Accessioni | Q8IIL5Primary (citable) accession number: Q8IIL5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | September 22, 2009 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |