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Protein

Probable cathepsin C

Gene

PF11_0174

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol protease. Has a role as a digestive enzyme.

Cofactori

chlorideBy similarityNote: Binds 1 Cl- ion per heavy chain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei398By similarity1
Binding sitei450ChlorideBy similarity1
Binding sitei549ChlorideBy similarity1
Active sitei624By similarity1
Active sitei648By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15382

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cathepsin C (EC:3.4.22.-)
Gene namesi
ORF Names:PF11_0174
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1116700

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • food vacuole Source: GeneDB
  • symbiont-containing vacuole Source: GeneDB

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1250372

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000026355? – 700Probable cathepsin C
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000002635428 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi395 ↔ 446By similarity
Modified residuei416Sulfothreonine1 Publication1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi490N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation, Zymogen

Proteomic databases

PRIDEiQ8IIJ9

Interactioni

Protein-protein interaction databases

BioGridi1206117, 3 interactors
IntActiQ8IIJ9, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8IIJ9
SMRiQ8IIJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000282290
InParanoidiQ8IIJ9
KOiK01275
OMAiCGSCYIA

Family and domain databases

Gene3Di2.40.128.80, 1 hit
InterProiView protein in InterPro
IPR014882 CathepsinC_exc
IPR036496 CathepsinC_exc_dom_sf
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08773 CathepsinC_exc, 1 hit
PF00112 Peptidase_C1, 2 hits
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
SSF75001 SSF75001, 2 hits
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IIJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRIFSVSF LLVLLNVLHI CIKFSVADLP THVETKNLLG KWKILRTKTS
60 70 80 90 100
PNLTTCGSSQ PNKNTYNVGI TDYKKYLLEN NYEFVSELNV ILSDDYVLYG
110 120 130 140 150
DIYNTQDNEH RSKWKVLAVY DENKRVIGTW TTICDEGFEI KIGNETYAAL
160 170 180 190 200
MHYEPNGKCG PVSDEDSLDS NGDTDCYTTS FSKIRYGWLD VENEKNEHLH
210 220 230 240 250
GCFYAERIFD NVNEIKHLDS FTIDKDSQNV LQTFTYDTKL NNILNSNNML
260 270 280 290 300
YKFGNLQKPT FTKRNNTNVQ FNSELNWHRM KHHGKKKPLK KSMLDASRQT
310 320 330 340 350
YACPCNANEV VDNVINKGDS DNPVSPTLIQ LNNNLKNTTQ TGNKDTNEMD
360 370 380 390 400
LENYEDTLNS PKRELEINEL PKNFTWGDPW NKNTREYEVT NQLLCGSCYI
410 420 430 440 450
ASQLYAFKRR IEVALTKKLD RKYLNNFDDQ LSIQTVLSCS FYDQGCNGGF
460 470 480 490 500
PYLVSKLAKL QGIPLNVYFP YSATEETCPY NISKHPNDMN GSAKLREINA
510 520 530 540 550
IFNSNNNMST YNNINNDHHQ LGVYANTASS QEQHGISEEN RWYAKDFNYV
560 570 580 590 600
GGCYGCNQCN GEKIMMNEIY RNGPIVSSFE ASPDFYDYAD GVYFVEDFPH
610 620 630 640 650
ARRCTIEPKN DGVYNITGWD RVNHAIVLLG WGEEEINGKL YKYWIGRNSW
660 670 680 690 700
GNGWGKEGYF KILRGQNFSG IESQSLFIEP DFSRGAGKIL LEKMQKELGN
Length:700
Mass (Da):80,412
Last modified:March 1, 2003 - v1
Checksum:iEFD504796C8D377B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014186 Genomic DNA Translation: AAN35758.1
RefSeqiXP_001347845.1, XM_001347809.1

Genome annotation databases

GeneDBiPF3D7_1116700.1:pep
GeneIDi810721
KEGGipfa:PF11_0174

Similar proteinsi

Entry informationi

Entry nameiCATC_PLAF7
AccessioniPrimary (citable) accession number: Q8IIJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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