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UniProtKB - Q8IID5 (Q8IID5_PLAF7)

Entry version 148 (25 May 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein
Submitted name:

Calcium-dependent protein kinase 6

Gene

PF3D7_1122800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1486Calcium 1Combined sources1
Metal bindingi1488Calcium 1Combined sources1
Metal bindingi1490Calcium 1Combined sources1
Metal bindingi1492Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi1555Calcium 2Combined sources1
Metal bindingi1559Calcium 2Combined sources1
Metal bindingi1561Calcium 2; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase
LigandCalciumCombined sourcesARBA annotation, Metal-bindingCombined sourcesARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-PFA-5687128, MAPK6/MAPK4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium-dependent protein kinase 6Imported (EC:2.7.11.17Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1122800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		PlasmoDB:PF3D7_1122800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8IID5, 9 interactors

STRING: functional protein association networks

More...STRINGi		5833.PF11_0239

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8IID5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IID5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8IID5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1066 – 1101EF-handInterPro annotationAdd BLAST36
Domaini1178 – 1430Protein kinaseInterPro annotationAdd BLAST253
Domaini1473 – 1508EF-handInterPro annotationAdd BLAST36
Domaini1542 – 1577EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni176 – 211DisorderedSequence analysisAdd BLAST36
Regioni297 – 439DisorderedSequence analysisAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili697 – 717Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 209Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi301 – 402Acidic residuesSequence analysisAdd BLAST102
Compositional biasi403 – 420Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi421 – 438Acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003482_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IID5

Identification of Orthologs from Complete Genome Data

More...OMAi		VTPFYIK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IID5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13202, EF-hand_5, 2 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 4 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 3 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IID5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLEILKNNY KGNGENYYNK NKKHQKKNKG KINVLDDDEY DNENDDKNVD 
        60         70         80         90        100
SANNSELCYL YEIYKNGFNK EENNGIILSH KNNKKGLIYK NKINALYDNS 
       110        120        130        140        150
KEMLHYRNQE NEENDIFEED IYENDNFDDN NFVEEENVEY KTYNSFTNEE 
       160        170        180        190        200
ANMLNNYSRV NIKNILDSHN INKRELYNKH NNNNGDNNNA NKKKNDQKNF 
       210        220        230        240        250
NKDDSNIREY SKNNNITRNL YKKNLLYFHE KYNEKDKSTY EYHIDACDNF 
       260        270        280        290        300
YEYGDEYNSN HKSKGKNIFE IKDVNIDRKG TKKFQKLDKN KETTKDMDYD 
       310        320        330        340        350
YYDEDNVDYE DDNVEGEDDN IEDEDDNIED EDDNIEDEDD NIEVEDDNVD 
       360        370        380        390        400
DEDDNVDDED DNIDDEDDNV DDEDDNVDDE DDNVDDEDDN VDDEDDHISD 
       410        420        430        440        450
EDYKDDKEDN YIKYNENDNV NDDEDNYYDE EENNYNNDDN YDEEIKDFNK 
       460        470        480        490        500
YLKNNDKEES IKNDVNKELS HFNFNNDLKQ KYIDVKGFKN ENIFNFKNII 
       510        520        530        540        550
KEDNNTLKRE ELFSFGNGKK LYNREENKIE VATFGMCNKN EWFEKYDVKI 
       560        570        580        590        600
ENCKKYNNYK NENNDNKNKN PFGFKGLDKH IEEKEEYDKM YMDGNNYMKG 
       610        620        630        640        650
KLIGNISPKI QRSHTDNNIE NYISDSENMN TYNIMNEVNR VLPYNNINNN 
       660        670        680        690        700
INNNNNNNKL IYNQGDTLNS IEHTNNISKY TTVDYSNDIL KTGKETYKEL 
       710        720        730        740        750
TKRKNEEICE LLNSEDKKKH NIKHFLDKMK SKKHIEDFFK KEDKICERSE 
       760        770        780        790        800
KKEKLKIKFT DILHAGAFGH FFHRNKNGLS RSFVSSDVKR NNSFNSINKI 
       810        820        830        840        850
NKKDQLKYNT LEKYETKIGA FDESKLGNVR NDKTVSYNQI ECKNSINYNS 
       860        870        880        890        900
KTELNIDKNK DFNFDKNKWY KMNDNEEKIH FLKFPNGLLD NDKKKELKSN 
       910        920        930        940        950
DNGIDDKLLS YVEDVKYKKY NDMSKQKNGI PKQIVNNRRN MINKDYYEKK 
       960        970        980        990       1000
YNIKVNRNNE ENGVDEKMLS VHGGVFNKND FEYGGKIKGI PNFPLNIEFI 
      1010       1020       1030       1040       1050
KQNGRYKEKG NEKYENDLEV NIDQTLSRKM LENNKLKKQN NIDEDIMVTP 
      1060       1070       1080       1090       1100
FYIKSKIDKV LKNNEIFEKS ARATFQQFDV KNKNFLHFSE IESLIQKLCH 
      1110       1120       1130       1140       1150
NLELPPVDKN ILSIVYKDYD SSKNNRMNYT DFRQMYWDLL KQIKKKYYPT 
      1160       1170       1180       1190       1200
KNFKIKRNCI ISRKKLGGYD YSSIYNYLSF KKILGYGAFG EVHLVEDNIC 
      1210       1220       1230       1240       1250
KLYKVVKILK KKSMKHIKIN EEINVLIYLD HPNIIKIFDV YENVDCTYIV 
      1260       1270       1280       1290       1300
MELCEGGELM SRIKNSESFN ETYIKNIMFQ ILCAIAYMHS NNIAHKDLKP 
      1310       1320       1330       1340       1350
ENILFKEKGD DTLKIIDFGL AELINKSEGI SKTAAGTVLY MAPEVFKKKF 
      1360       1370       1380       1390       1400
TIKCDIWSAG VIMFFLFTKS LPFGGNTYDE VKQSIFRDEP DYKSLKSKLS 
      1410       1420       1430       1440       1450
QTALHMLKLM LQKDYNKRPM ASVLLHHPWF QGYFDPIQIS PNVLNNMKSY 
      1460       1470       1480       1490       1500
MKHSNIRNII INIMAHELSV INNHIKYINE LFYKLDTNHN GSLSHREIYT 
      1510       1520       1530       1540       1550
VLASVGIKKW DINRILQALD INDRGNITYT EFMAGCYRWK NIESTFLKAA 
      1560       1570       1580       1590       1600
FNKIDKDEDG YISKSDIVSL VHDKVLDNND IDNFFLSVHS IKKGIPREHI 
      1610 
INKISFQEFK DYMLSTF
Length:1,617
Mass (Da):191,814
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E3323B1F4DB8FC6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98890.1

NCBI Reference Sequences

More...RefSeqi		XP_001347910.1, XM_001347874.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CZT98890; CZT98890; PF3D7_1122800

Database of genes from NCBI RefSeq genomes

More...GeneIDi		810786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pfa:PF3D7_1122800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98890.1
RefSeqiXP_001347910.1, XM_001347874.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MSEX-ray2.10B1439-1617[»]
AlphaFoldDBiQ8IID5
SMRiQ8IID5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ8IID5, 9 interactors
STRINGi5833.PF11_0239

Genome annotation databases

EnsemblProtistsiCZT98890; CZT98890; PF3D7_1122800
GeneIDi810786
KEGGipfa:PF3D7_1122800

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1122800

Phylogenomic databases

HOGENOMiCLU_003482_0_0_1
InParanoidiQ8IID5
OMAiVTPFYIK
PhylomeDBiQ8IID5

Enzyme and pathway databases

ReactomeiR-PFA-5687128, MAPK6/MAPK4 signaling

Miscellaneous databases

EvolutionaryTraceiQ8IID5

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13202, EF-hand_5, 2 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 4 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 3 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IID5_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IID5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 25, 2022
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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