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Entry version 148 (25 May 2022)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Calcium-dependent protein kinase 6

Gene

PF3D7_1122800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1486Calcium 1Combined sources1
Metal bindingi1488Calcium 1Combined sources1
Metal bindingi1490Calcium 1Combined sources1
Metal bindingi1492Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi1555Calcium 2Combined sources1
Metal bindingi1559Calcium 2Combined sources1
Metal bindingi1561Calcium 2; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase
LigandCalciumCombined sourcesARBA annotation, Metal-bindingCombined sourcesARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-5687128, MAPK6/MAPK4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium-dependent protein kinase 6Imported (EC:2.7.11.17Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1122800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_1122800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8IID5, 9 interactors

STRING: functional protein association networks

More...
STRINGi
5833.PF11_0239

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q8IID5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IID5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IID5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1066 – 1101EF-handInterPro annotationAdd BLAST36
Domaini1178 – 1430Protein kinaseInterPro annotationAdd BLAST253
Domaini1473 – 1508EF-handInterPro annotationAdd BLAST36
Domaini1542 – 1577EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni176 – 211DisorderedSequence analysisAdd BLAST36
Regioni297 – 439DisorderedSequence analysisAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili697 – 717Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 209Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi301 – 402Acidic residuesSequence analysisAdd BLAST102
Compositional biasi403 – 420Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi421 – 438Acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003482_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IID5

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTPFYIK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IID5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13202, EF-hand_5, 2 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 4 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 3 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IID5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLEILKNNY KGNGENYYNK NKKHQKKNKG KINVLDDDEY DNENDDKNVD
60 70 80 90 100
SANNSELCYL YEIYKNGFNK EENNGIILSH KNNKKGLIYK NKINALYDNS
110 120 130 140 150
KEMLHYRNQE NEENDIFEED IYENDNFDDN NFVEEENVEY KTYNSFTNEE
160 170 180 190 200
ANMLNNYSRV NIKNILDSHN INKRELYNKH NNNNGDNNNA NKKKNDQKNF
210 220 230 240 250
NKDDSNIREY SKNNNITRNL YKKNLLYFHE KYNEKDKSTY EYHIDACDNF
260 270 280 290 300
YEYGDEYNSN HKSKGKNIFE IKDVNIDRKG TKKFQKLDKN KETTKDMDYD
310 320 330 340 350
YYDEDNVDYE DDNVEGEDDN IEDEDDNIED EDDNIEDEDD NIEVEDDNVD
360 370 380 390 400
DEDDNVDDED DNIDDEDDNV DDEDDNVDDE DDNVDDEDDN VDDEDDHISD
410 420 430 440 450
EDYKDDKEDN YIKYNENDNV NDDEDNYYDE EENNYNNDDN YDEEIKDFNK
460 470 480 490 500
YLKNNDKEES IKNDVNKELS HFNFNNDLKQ KYIDVKGFKN ENIFNFKNII
510 520 530 540 550
KEDNNTLKRE ELFSFGNGKK LYNREENKIE VATFGMCNKN EWFEKYDVKI
560 570 580 590 600
ENCKKYNNYK NENNDNKNKN PFGFKGLDKH IEEKEEYDKM YMDGNNYMKG
610 620 630 640 650
KLIGNISPKI QRSHTDNNIE NYISDSENMN TYNIMNEVNR VLPYNNINNN
660 670 680 690 700
INNNNNNNKL IYNQGDTLNS IEHTNNISKY TTVDYSNDIL KTGKETYKEL
710 720 730 740 750
TKRKNEEICE LLNSEDKKKH NIKHFLDKMK SKKHIEDFFK KEDKICERSE
760 770 780 790 800
KKEKLKIKFT DILHAGAFGH FFHRNKNGLS RSFVSSDVKR NNSFNSINKI
810 820 830 840 850
NKKDQLKYNT LEKYETKIGA FDESKLGNVR NDKTVSYNQI ECKNSINYNS
860 870 880 890 900
KTELNIDKNK DFNFDKNKWY KMNDNEEKIH FLKFPNGLLD NDKKKELKSN
910 920 930 940 950
DNGIDDKLLS YVEDVKYKKY NDMSKQKNGI PKQIVNNRRN MINKDYYEKK
960 970 980 990 1000
YNIKVNRNNE ENGVDEKMLS VHGGVFNKND FEYGGKIKGI PNFPLNIEFI
1010 1020 1030 1040 1050
KQNGRYKEKG NEKYENDLEV NIDQTLSRKM LENNKLKKQN NIDEDIMVTP
1060 1070 1080 1090 1100
FYIKSKIDKV LKNNEIFEKS ARATFQQFDV KNKNFLHFSE IESLIQKLCH
1110 1120 1130 1140 1150
NLELPPVDKN ILSIVYKDYD SSKNNRMNYT DFRQMYWDLL KQIKKKYYPT
1160 1170 1180 1190 1200
KNFKIKRNCI ISRKKLGGYD YSSIYNYLSF KKILGYGAFG EVHLVEDNIC
1210 1220 1230 1240 1250
KLYKVVKILK KKSMKHIKIN EEINVLIYLD HPNIIKIFDV YENVDCTYIV
1260 1270 1280 1290 1300
MELCEGGELM SRIKNSESFN ETYIKNIMFQ ILCAIAYMHS NNIAHKDLKP
1310 1320 1330 1340 1350
ENILFKEKGD DTLKIIDFGL AELINKSEGI SKTAAGTVLY MAPEVFKKKF
1360 1370 1380 1390 1400
TIKCDIWSAG VIMFFLFTKS LPFGGNTYDE VKQSIFRDEP DYKSLKSKLS
1410 1420 1430 1440 1450
QTALHMLKLM LQKDYNKRPM ASVLLHHPWF QGYFDPIQIS PNVLNNMKSY
1460 1470 1480 1490 1500
MKHSNIRNII INIMAHELSV INNHIKYINE LFYKLDTNHN GSLSHREIYT
1510 1520 1530 1540 1550
VLASVGIKKW DINRILQALD INDRGNITYT EFMAGCYRWK NIESTFLKAA
1560 1570 1580 1590 1600
FNKIDKDEDG YISKSDIVSL VHDKVLDNND IDNFFLSVHS IKKGIPREHI
1610
INKISFQEFK DYMLSTF
Length:1,617
Mass (Da):191,814
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E3323B1F4DB8FC6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98890.1

NCBI Reference Sequences

More...
RefSeqi
XP_001347910.1, XM_001347874.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98890; CZT98890; PF3D7_1122800

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
810786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1122800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98890.1
RefSeqiXP_001347910.1, XM_001347874.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MSEX-ray2.10B1439-1617[»]
AlphaFoldDBiQ8IID5
SMRiQ8IID5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ8IID5, 9 interactors
STRINGi5833.PF11_0239

Genome annotation databases

EnsemblProtistsiCZT98890; CZT98890; PF3D7_1122800
GeneIDi810786
KEGGipfa:PF3D7_1122800

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1122800

Phylogenomic databases

HOGENOMiCLU_003482_0_0_1
InParanoidiQ8IID5
OMAiVTPFYIK
PhylomeDBiQ8IID5

Enzyme and pathway databases

ReactomeiR-PFA-5687128, MAPK6/MAPK4 signaling

Miscellaneous databases

EvolutionaryTraceiQ8IID5

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13202, EF-hand_5, 2 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 4 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 3 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IID5_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IID5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 25, 2022
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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