UniProtKB - Q8IIC3 (Q8IIC3_PLAF7)
Protein
Submitted name:
Endoplasmic reticulum oxidoreductin, putative
Gene
PF3D7_1124000
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Cofactori
FADUniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 186 | FADUniRule annotation | 1 | |
Binding sitei | 194 | FADUniRule annotation | 1 | |
Binding sitei | 221 | FADUniRule annotation | 1 | |
Binding sitei | 272 | FADUniRule annotation | 1 | |
Active sitei | 365 | NucleophileUniRule annotation | 1 | |
Active sitei | 368 | UniRule annotation | 1 |
GO - Molecular functioni
- oxidoreductase activity Source: GeneDB
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Source: InterPro
- protein disulfide isomerase activity Source: GO_Central
- protein disulfide oxidoreductase activity Source: GO_Central
GO - Biological processi
- protein folding Source: GeneDB
- protein folding in endoplasmic reticulum Source: GO_Central
Keywordsi
Molecular function | IsomeraseImported |
Biological process | Electron transportARBA annotation, Transport |
Ligand | FADUniRule annotation, Flavoprotein |
Enzyme and pathway databases
Reactomei | R-PFA-3299685, Detoxification of Reactive Oxygen Species |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1124000Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1124000 |
Subcellular locationi
- Endoplasmic reticulum membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Lumenal side ARBA annotation
GO - Cellular componenti
- endoplasmic reticulum Source: GeneDB
- endoplasmic reticulum membrane Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, MembraneARBA annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 111 ↔ 117 | Redox-activeUniRule annotation | ||
Disulfide bondi | 365 ↔ 368 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | Q8IIC3 |
PTM databases
SwissPalmi | Q8IIC3 |
Family & Domainsi
Sequence similaritiesi
Belongs to the EROs family.ARBA annotation
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
HOGENOMi | CLU_588621_0_0_1 |
OMAi | YRENCFQ |
Family and domain databases
InterProi | View protein in InterPro IPR007266, Ero1 IPR037192, ERO1-like_sf |
PANTHERi | PTHR12613, PTHR12613, 1 hit |
Pfami | View protein in Pfam PF04137, ERO1, 1 hit |
PIRSFi | PIRSF017205, ERO1, 1 hit |
SUPFAMi | SSF110019, SSF110019, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IIC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKICLIPVFL SLIIYVILFL KGKKIGDLYI TEHLRNKFEN ILLYFNIFEV
60 70 80 90 100
QYPESYLNNE KLLGLHVRDI EKDAYRAYPI LKELKQKDYF RIFKVNLHLS
110 120 130 140 150
CKVFLKGNEK CKEIKKCSVC ECEQDEIPYN FRTNEIEIIE NKMTNEDLKK
160 170 180 190 200
TFIESKLYKD ILGIYAPSNE GFISYVDLVY NSPSFTAYEG RNIWNMIYKE
210 220 230 240 250
NCFQNEKSEC EEMNSFYKII SGMQSNIAVL SSEYFYLKND FLFGEIQINN
260 270 280 290 300
KFNNDYFKNL NYDYSVTFFK EKIGLYPERI ENLYFTFAIL LRSMCRLKSL
310 320 330 340 350
FKQCKCNSGY EQNDKEAVRL LDDLLENFYH SCSSKEFLEP LFPQHGKDIL
360 370 380 390 400
SKFMNITNIL DCVPCVKCRL HGKLKTTALQ IALVEGVSDE HIGSLERNEI
410 420 430 440 450
TALINALYYF ADSILIINKF EDRLKLKKTI FIFYVLSFSL FLFLVIYSII
460
FLTIRNYKKK KKKVA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999945 Genomic DNA Translation: CZT98902.1 |
RefSeqi | XP_001347922.2, XM_001347886.2 |
Genome annotation databases
EnsemblProtistsi | CZT98902; CZT98902; PF3D7_1124000 |
GeneDBi | PF3D7_1124000.1:pep |
GeneIDi | 810798 |
KEGGi | pfa:PF3D7_1124000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999945 Genomic DNA Translation: CZT98902.1 |
RefSeqi | XP_001347922.2, XM_001347886.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | Q8IIC3 |
Proteomic databases
PRIDEi | Q8IIC3 |
Genome annotation databases
EnsemblProtistsi | CZT98902; CZT98902; PF3D7_1124000 |
GeneDBi | PF3D7_1124000.1:pep |
GeneIDi | 810798 |
KEGGi | pfa:PF3D7_1124000 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1124000 |
Phylogenomic databases
HOGENOMi | CLU_588621_0_0_1 |
OMAi | YRENCFQ |
Enzyme and pathway databases
Reactomei | R-PFA-3299685, Detoxification of Reactive Oxygen Species |
Family and domain databases
InterProi | View protein in InterPro IPR007266, Ero1 IPR037192, ERO1-like_sf |
PANTHERi | PTHR12613, PTHR12613, 1 hit |
Pfami | View protein in Pfam PF04137, ERO1, 1 hit |
PIRSFi | PIRSF017205, ERO1, 1 hit |
SUPFAMi | SSF110019, SSF110019, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IIC3_PLAF7 | |
Accessioni | Q8IIC3Primary (citable) accession number: Q8IIC3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | September 22, 2009 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |