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UniProtKB - Q8IH00 (NOL6_DROME)

Entry version 117 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Nucleolar protein 6

Gene

Mat89Ba

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 6By similarity
Alternative name(s):
Maternal transcript 89Ba1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mat89Ba1 Publication
ORF Names:CG12785
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0261286, Mat89Ba

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003836241 – 1193Nucleolar protein 6Add BLAST1193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IH00

PRoteomics IDEntifications database

More...PRIDEi		Q8IH00

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IH00

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in nurse cells at stages 9-10 of oogenesis and exported to the oocyte.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0261286, Expressed in embryo and 47 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IH00, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be associated with rRNA.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		67021, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q8IH00, 8 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0082727

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IH00

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAP family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2054, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003502_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IH00

Identification of Orthologs from Complete Genome Data

More...OMAi		VWNQLAN

Database of Orthologous Groups

More...OrthoDBi		176625at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IH00

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005554, NOL6/Upt22
IPR035082, Nrap_D1
IPR035367, Nrap_D2
IPR035368, Nrap_D3
IPR035369, Nrap_D4
IPR035370, Nrap_D5
IPR035371, Nrap_D6
IPR043519, NT_sf

The PANTHER Classification System

More...PANTHERi		PTHR17972, PTHR17972, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03813, Nrap, 1 hit
PF17403, Nrap_D2, 1 hit
PF17404, Nrap_D3, 1 hit
PF17405, Nrap_D4, 1 hit
PF17406, Nrap_D5, 1 hit
PF17407, Nrap_D6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IH00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFVQGNIMP GKLVGSPKGA ARTGTQAIAH AGDHSDLDEP KPKIAKSDPP 
        60         70         80         90        100
STAIPKKNNF KQREGTKNVK PPTLEEMKEL RDTQNLFHSN LFKLQVKEML 
       110        120        130        140        150
EELQLKQKYT DFIENWLESF TAFTRQLKDG LMERTHLEVP MKLSEKPTGF 
       160        170        180        190        200
VFSKPTREPY LIGAAATGTL LGPKIVVDVA LEMPKESLHK EDYLNLRYDQ 
       210        220        230        240        250
KRALYLTYVT ERMMESPDYA EDQFNFNYYA NNPLKPVLEL IPVTKQVNKH 
       260        270        280        290        300
LQVRLFITAP LSSFKPGRFV PWNNNIRPSF YGDEWDEKDP LPSTQHYNAN 
       310        320        330        340        350
VLFDLTLSEN QAQLDKAFKS RRNFQDGLLL LKVWLRQRQL DIGYSGFGAH 
       360        370        380        390        400
ILAAFIVYLN TQRILHQSSS SYQVARTVWN QLANTDWTKG ISLSVAPIQT 
       410        420        430        440        450
EELNKFAEHY DVCFIDFTGQ HNLCANIPLY LYQRVREEAK LAVELLNDMK 
       460        470        480        490        500
LNSFPLIFMQ KCPLYSRVDN ILKISNYSCI NQMLTLHSHP RIKYDFANYG 
       510        520        530        540        550
YPQLLHLLTE LLKKGLAERV HSILPLETAT AAWPVEKKAP VIGKYIQLGL 
       560        570        580        590        600
ILQPEHAYQV LNKGPAANDD HEGAEEFRRF WGEKSNLRRF QDGSITEAVV 
       610        620        630        640        650
WGTAQDSPAK KRLIVRQIVL HLLEHHLQLD SKEVQYIGGE LDQVYQLSPW 
       660        670        680        690        700
FKVNKLKTKL PLGQDTDAEA LSPHVIRCYD ELARQLHGLN DLPLEIVSIS 
       710        720        730        740        750
GVSPIFRYCE PQPVLPQALL VENRILASSI QRVVIQLGQS GKWPTELGAL 
       760        770        780        790        800
RALKTAFLIE IGEKLEAQCR LHWVMSADGL LVLKQGYCFL IELAHNKELA 
       810        820        830        840        850
LLKQEVTERG ITTYIDNAAS RSLERQHYIL PKVSGALHSL HQTYSAFGST 
       860        870        880        890        900
VLLAKRWLAT QLLDDGLWPD MATELLVAHL FQQRYAPQSI AAPQTGFIRF 
       910        920        930        940        950
LQLLSHSDFN GELFLLNFNN SWQEQQIADL EHNYRSNRQS YPPLAVATSY 
       960        970        980        990       1000
DMQHAGRLWT SDQSPSQRVL GHVTRLARHA LEIIETSLMS KDLRFVRPAQ 
      1010       1020       1030       1040       1050
LFRASNEGYD LVIQFKPDLV PNSLSYDLGS PFVSFSQPNF SLPRAGSDYI 
      1060       1070       1080       1090       1100
ARIVGLLRSA YSDFAAFFYN PHGGKELGIV WRPPTEFAAK PFKVTELQAC 
      1110       1120       1130       1140       1150
SPCGNKKVQV LKETLLEDFK LLLKDFYLRI ATPEELKREQ REHQKPMRYF 
      1160       1170       1180       1190 
DANKAEEESK PKPKKHRQRK GTGKKALPKR KRLIKSSTLK VLK
Length:1,193
Mass (Da):136,385
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48175B8B5280D893
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55292.2
BT001511 mRNA Translation: AAN71266.1
BT016113 mRNA Translation: AAV36998.1
U47618 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_650530.2, NM_142273.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0083275; FBpp0082727; FBgn0261286

Database of genes from NCBI RefSeq genomes

More...GeneIDi		41973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12785

UCSC genome browser

More...UCSCi		CG12785-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55292.2
BT001511 mRNA Translation: AAN71266.1
BT016113 mRNA Translation: AAV36998.1
U47618 Genomic DNA No translation available.
RefSeqiNP_650530.2, NM_142273.4

3D structure databases

SMRiQ8IH00
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi67021, 4 interactors
IntActiQ8IH00, 8 interactors
STRINGi7227.FBpp0082727

PTM databases

iPTMnetiQ8IH00

Proteomic databases

PaxDbiQ8IH00
PRIDEiQ8IH00

Genome annotation databases

EnsemblMetazoaiFBtr0083275; FBpp0082727; FBgn0261286
GeneIDi41973
KEGGidme:Dmel_CG12785
UCSCiCG12785-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		41973
FlyBaseiFBgn0261286, Mat89Ba

Phylogenomic databases

eggNOGiKOG2054, Eukaryota
GeneTreeiENSGT00390000018619
HOGENOMiCLU_003502_0_1_1
InParanoidiQ8IH00
OMAiVWNQLAN
OrthoDBi176625at2759
PhylomeDBiQ8IH00

Enzyme and pathway databases

ReactomeiR-DME-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		41973, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		41973

Protein Ontology

More...PROi		PR:Q8IH00

Gene expression databases

BgeeiFBgn0261286, Expressed in embryo and 47 other tissues
GenevisibleiQ8IH00, DM

Family and domain databases

Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR005554, NOL6/Upt22
IPR035082, Nrap_D1
IPR035367, Nrap_D2
IPR035368, Nrap_D3
IPR035369, Nrap_D4
IPR035370, Nrap_D5
IPR035371, Nrap_D6
IPR043519, NT_sf
PANTHERiPTHR17972, PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813, Nrap, 1 hit
PF17403, Nrap_D2, 1 hit
PF17404, Nrap_D3, 1 hit
PF17405, Nrap_D4, 1 hit
PF17406, Nrap_D5, 1 hit
PF17407, Nrap_D6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOL6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IH00
Secondary accession number(s): Q9VEX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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