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Protein

Thioredoxin-T

Gene

TrxT

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline.

Miscellaneous

The TrxT gene, which encodes an testis specific thioredoxin, is adjacent to the dhd gene and shares some regulatory region with it.

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to oxidative stress Source: GO_Central
  • glycerol ether metabolic process Source: InterPro
  • oxidation-reduction process Source: UniProtKB
  • protein folding Source: FlyBase

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-T
Short name:
ThioredoxinT
Gene namesi
Name:TrxT
ORF Names:CG3315
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0029752 TrxT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200361 – 157Thioredoxin-TAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 35Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8IFW4
PRIDEiQ8IFW4

Expressioni

Tissue specificityi

Testis specific. Not expressed in the embryo. Becomes progressively more strongly expressed during larval and pupal development. In testis, it is strongly expressed in young spermatocytes, and postmeiotic spermatid stages, then expression decreases at the nuclear elongation stage. Strongly expressed in the waste bag, in which material no longer needed for the mature sperm is eliminated. Not expressed in the stem cells and spermatogonial cells.1 Publication

Developmental stagei

Not expressed maternally.1 Publication

Gene expression databases

BgeeiFBgn0029752
ExpressionAtlasiQ8IFW4 baseline and differential
GenevisibleiQ8IFW4 DM

Interactioni

Protein-protein interaction databases

BioGridi57953, 1 interactor
IntActiQ8IFW4, 12 interactors
STRINGi7227.FBpp0070722

Structurei

3D structure databases

ProteinModelPortaliQ8IFW4
SMRiQ8IFW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 107ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907 Eukaryota
COG0526 LUCA
InParanoidiQ8IFW4
KOiK03671
OrthoDBiEOG091G01FG
PhylomeDBiQ8IFW4

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IFW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYPVRNKDD LDQQLILAED KLVVIDFYAD WCGPCKIIAP KLDELAHEYS
60 70 80 90 100
DRVVVLKVNV DENEDITVEY NVNSMPTFVF IKGGNVLELF VGCNSDKLAK
110 120 130 140 150
LMEKHAGVYT DEAADVKAVH IDGECIVDLT AESSESDNDN NNVNEVSAHD

ENAVLEH
Length:157
Mass (Da):17,499
Last modified:March 1, 2003 - v1
Checksum:i5D8EAB28344BFA6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47 – 48HE → QQ in AAF46018 (PubMed:10731132).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507731 mRNA Translation: CAD45644.1
AE014298 Genomic DNA Translation: AAF46018.2
RefSeqiNP_001284881.1, NM_001297952.1
NP_572212.1, NM_131984.1
UniGeneiDm.8001

Genome annotation databases

GeneIDi31443
KEGGidme:Dmel_CG3315

Similar proteinsi

Entry informationi

Entry nameiTHIOT_DROME
AccessioniPrimary (citable) accession number: Q8IFW4
Secondary accession number(s): Q9W4D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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