UniProtKB - Q8IE14 (Q8IE14_PLAF7)
Protein
Signal peptidase I
Gene
PF3D7_1331300
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
- Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.ARBA annotation EC:3.4.21.89
GO - Molecular functioni
- peptidase activity Source: GeneDB
- serine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- signal peptide processing Source: GeneDB
Keywordsi
Molecular function | Hydrolase, ProteaseARBA annotation |
Protein family/group databases
MEROPSi | S26.010 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1331300Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1331300 |
Subcellular locationi
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 183 | HelicalSequence analysisAdd BLAST | 18 |
GO - Cellular componenti
- endoplasmic reticulum Source: GeneDB
- integral component of membrane Source: UniProtKB-KW
- signal peptidase complex Source: GeneDB
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 131 | Peptidase_S24InterPro annotationAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the peptidase S26B family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_089996_0_0_1 |
InParanoidi | Q8IE14 |
OMAi | MLTIWVN |
PhylomeDBi | Q8IE14 |
Family and domain databases
InterProi | View protein in InterPro IPR036286, LexA/Signal_pep-like_sf IPR019758, Pept_S26A_signal_pept_1_CS IPR015927, Peptidase_S24_S26A/B/C IPR001733, Peptidase_S26B |
PANTHERi | PTHR10806, PTHR10806, 1 hit |
Pfami | View protein in Pfam PF00717, Peptidase_S24, 1 hit |
PRINTSi | PR00728, SIGNALPTASE |
SUPFAMi | SSF51306, SSF51306, 1 hit |
TIGRFAMsi | TIGR02228, sigpep_I_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00761, SPASE_I_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IE14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFIKEQYNS LVLDLRKTFR NKRDGLSHIL NVICLLLNAL MIWKLLVVFT
60 70 80 90 100
GCESPVVVVL SGSMEPGYYR GDTLALYHPP KIHAGDVVVY QINGRDIPIV
110 120 130 140 150
HRILSLHTSK DNKFHLLSKG DNNNIDDRGL YDPHQYWLEN EHVLGLSVGY
160 170 180
TPYIGILTIW INEYPVVKWA IVSIMLIMIL MGYE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844509 Genomic DNA Translation: CAD52453.1 |
RefSeqi | XP_001350045.1, XM_001350009.1 |
Genome annotation databases
EnsemblProtistsi | CAD52453; CAD52453; PF3D7_1331300 |
GeneDBi | PF3D7_1331300.1:pep |
GeneIDi | 813720 |
KEGGi | pfa:PF3D7_1331300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844509 Genomic DNA Translation: CAD52453.1 |
RefSeqi | XP_001350045.1, XM_001350009.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | S26.010 |
PTM databases
SwissPalmi | Q8IE14 |
Proteomic databases
PRIDEi | Q8IE14 |
Genome annotation databases
EnsemblProtistsi | CAD52453; CAD52453; PF3D7_1331300 |
GeneDBi | PF3D7_1331300.1:pep |
GeneIDi | 813720 |
KEGGi | pfa:PF3D7_1331300 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1331300 |
Phylogenomic databases
HOGENOMi | CLU_089996_0_0_1 |
InParanoidi | Q8IE14 |
OMAi | MLTIWVN |
PhylomeDBi | Q8IE14 |
Family and domain databases
InterProi | View protein in InterPro IPR036286, LexA/Signal_pep-like_sf IPR019758, Pept_S26A_signal_pept_1_CS IPR015927, Peptidase_S24_S26A/B/C IPR001733, Peptidase_S26B |
PANTHERi | PTHR10806, PTHR10806, 1 hit |
Pfami | View protein in Pfam PF00717, Peptidase_S24, 1 hit |
PRINTSi | PR00728, SIGNALPTASE |
SUPFAMi | SSF51306, SSF51306, 1 hit |
TIGRFAMsi | TIGR02228, sigpep_I_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00761, SPASE_I_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IE14_PLAF7 | |
Accessioni | Q8IE14Primary (citable) accession number: Q8IE14 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |