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Protein

DNA topoisomerase

Gene

PF3D7_1347100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.UniRule annotation

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • DNA topological change Source: GO_Central
  • DNA unwinding involved in DNA replication Source: GeneDB

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseUniRule annotation (EC:5.99.1.2UniRule annotation)
Gene namesi
ORF Names:PF3D7_1347100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1347100

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ8IDM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 151ToprimInterPro annotationAdd BLAST147

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili313 – 333Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the type IA topoisomerase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000184377
InParanoidiQ8IDM7
KOiK03165
OMAiKPFTEGD
PhylomeDBiQ8IDM7

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
cd03362 TOPRIM_TopoIA_TopoIII, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 2 hits
2.70.20.10, 2 hits
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR003601 Topo_IA_2
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
IPR006171 TOPRIM_domain
IPR034144 TOPRIM_TopoIII
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 2 hits
PF01751 Toprim, 1 hit
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SM00436 TOP1Bc, 1 hit
SM00493 TOPRIM, 1 hit
SUPFAMiSSF56712 SSF56712, 2 hits
PROSITEiView protein in PROSITE
PS50880 TOPRIM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IDM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLKVLNVA EKPSVASSIA EILSKGRPNK IKSCSKYNPV FTFDYKIKND
60 70 80 90 100
IWYMYVTSVT GHLTDQKFDD RYKNWHNTDP QELFDAEITV YVEKDKKNIE
110 120 130 140 150
NNLKKYSKEC NMLILWLDCD REGEHICFEV INACRITNRK LIIHRAQFSA
160 170 180 190 200
VTEKDIIHAI NNLKEPNKNL AYSVDVRREI DLRMGSIFTR FMTIRYIELV
210 220 230 240 250
KHETSIISYG PCQFPTLGFV VNRYLDIKNF KNEYYWSIKM KYVYNNDEIN
260 270 280 290 300
PMDDENNYDD HDDEQMDSDS DESDSYYTNN DDSNNYSDET DDYYGDEKKK
310 320 330 340 350
KKKKKTKKKK KKKNSTKKKK KKKKNKINNN NKKNKHNNVV DFTWSRIRLF
360 370 380 390 400
DHLAVILIYE ELLKNPLCKI TNVYESETRK YKPYPLNTLQ MTKLVSIYFK
410 420 430 440 450
ISSKECMMLA EKLYNKGYIS YPRTETNYFP DSMNLHKIIN ELRKNDNFGW
460 470 480 490 500
YANKLCEEHK YQKPRKGKMN DKAHPPIHPV KNMNKSLKVE EKEWKLYEFI
510 520 530 540 550
CKHFLAVCSN DAIGYNTKVT AKIQEEQFFC KGLKIKEKNY LEIYTYEKWN
560 570 580 590 600
DKIIPSFQVD DEFYPTSLLI EEGITQPPKY LSESNLLTLM DKFSIGTDAT
610 620 630 640 650
MHEHIENIQK RNYVIKNSKS LFIPTNLGIA LVQSYKKFKD IGIDLTDPSL
660 670 680 690 700
RAKMEKDMSL VASGVKQKNE IIRNYIDIMK YIYQEIYNRI DVLDKNIHYY
710
LNNPDQLSYT
Length:710
Mass (Da):84,306
Last modified:March 1, 2003 - v1
Checksum:i44286A56EEDB3AC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52594.1
RefSeqiXP_001350185.1, XM_001350149.1

Genome annotation databases

EnsemblProtistsiCAD52594; CAD52594; PF3D7_1347100
GeneDBiPF3D7_1347100.1:pep
GeneIDi814216
KEGGipfa:PF3D7_1347100

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52594.1
RefSeqiXP_001350185.1, XM_001350149.1

3D structure databases

ProteinModelPortaliQ8IDM7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD52594; CAD52594; PF3D7_1347100
GeneDBiPF3D7_1347100.1:pep
GeneIDi814216
KEGGipfa:PF3D7_1347100

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1347100

Phylogenomic databases

HOGENOMiHOG000184377
InParanoidiQ8IDM7
KOiK03165
OMAiKPFTEGD
PhylomeDBiQ8IDM7

Family and domain databases

CDDicd00186 TOP1Ac, 1 hit
cd03362 TOPRIM_TopoIA_TopoIII, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 2 hits
2.70.20.10, 2 hits
InterProiView protein in InterPro
IPR000380 Topo_IA
IPR003601 Topo_IA_2
IPR013497 Topo_IA_cen
IPR013824 Topo_IA_cen_sub1
IPR013825 Topo_IA_cen_sub2
IPR013826 Topo_IA_cen_sub3
IPR023405 Topo_IA_core_domain
IPR003602 Topo_IA_DNA-bd_dom
IPR006171 TOPRIM_domain
IPR034144 TOPRIM_TopoIII
PANTHERiPTHR11390 PTHR11390, 1 hit
PfamiView protein in Pfam
PF01131 Topoisom_bac, 2 hits
PF01751 Toprim, 1 hit
PRINTSiPR00417 PRTPISMRASEI
SMARTiView protein in SMART
SM00437 TOP1Ac, 1 hit
SM00436 TOP1Bc, 1 hit
SM00493 TOPRIM, 1 hit
SUPFAMiSSF56712 SSF56712, 2 hits
PROSITEiView protein in PROSITE
PS50880 TOPRIM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IDM7_PLAF7
AccessioniPrimary (citable) accession number: Q8IDM7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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