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Protein

Calcium-dependent protein kinase 2

Gene

CPK2

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent kinase that may play a role in mosquito transmission of P.falciparum.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Activated by calcium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101ATPPROSITE-ProRule annotation1
Active sitei192Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 86ATPPROSITE-ProRule annotation9
Calcium bindingi383 – 3941PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi419 – 4312PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi455 – 4663PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-dependent protein kinase 2 (EC:2.7.11.1)
Alternative name(s):
PfCDPK2
Gene namesi
Name:CPK2
Synonyms:CDPK2
ORF Names:MAL6P1.108, PFF0520w
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0610600

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000858372 – 509Calcium-dependent protein kinase 2Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

May be myristoylated; myristoylation may target it to different subcellular compartments.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiQ8ICR0

Expressioni

Developmental stagei

Expressed in sexual stages, but not in asexual stages.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8ICR0
SMRiQ8ICR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 326Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini370 – 405EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini406 – 441EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini442 – 477EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000233030
InParanoidiQ8ICR0
OMAiCACKAIS
PhylomeDBiQ8ICR0

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ICR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNHLSVNKL KRKKKKKSFL NIYGKNTNEN TSKQSNDYKY DINTSCISRE
60 70 80 90 100
GTTTLERKNL ILCHSGKLED KYIIDEKLGQ GTYGCVYKGI DKVTNQLYAI
110 120 130 140 150
KEEKKDRLKN INRFFQEIEI MKKLDHPNIV KLYETYENDN YIYLIMELCS
160 170 180 190 200
GRELFDSIIE NGSFTEKNAA TIMKQIFSAI FYLHSLNIVH RDLKPENFLF
210 220 230 240 250
QSENKDSLLK IIDFGLSKNL GTGEFTTTKA GTPYYVAPQV LDGKYDKKCD
260 270 280 290 300
IWSSGVIMYT LLCGYPPFYG DTDNEVLKKV KKGEFCFYEN DWGSISSDAK
310 320 330 340 350
NLITKLLTYN PNERCTIEEA LNHPWITQMT KSHEHVELSS TLLKNLKNFK
360 370 380 390 400
KENELKKIAL TIIAKHLCDV EINNLRNIFI ALDVDNSGTL SSQEILDGLK
410 420 430 440 450
KIGYQKIPPD IHQVLRDIDS NASGQIHYTD FLAATIDKQT YLKKEVCLIP
460 470 480 490 500
FKFFDIDGNG KISVEELKRI FGRDDIENPL IDKAIDSLLQ EVDLNGDGEV

NKNYNHEKG
Length:509
Mass (Da):58,465
Last modified:January 23, 2007 - v3
Checksum:iA2A90DF4904835FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844505 Genomic DNA Translation: CAG25347.1
RefSeqiXP_966095.1, XM_961002.1

Genome annotation databases

EnsemblProtistsiCAG25347; CAG25347; PF3D7_0610600
GeneDBiPF3D7_0610600.1:pep

Similar proteinsi

Entry informationi

Entry nameiCDPK2_PLAF7
AccessioniPrimary (citable) accession number: Q8ICR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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