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Protein
Submitted name:

Cullin-1, putative

Gene

PF3D7_0811000

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-PFA-68949 Orc1 removal from chromatin
R-PFA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-PFA-917937 Iron uptake and transport
R-PFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Cullin-1, putativeImported
Gene namesi
ORF Names:PF3D7_0811000Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0811000

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PRIDEiQ8IAU5

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8IAU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini440 – 709CULLIN_2InterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000280965
InParanoidiQ8IAU5
KOiK03347
OMAiTTHKHIE
PhylomeDBiQ8IAU5

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR016159 Cullin_repeat-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
PF10557 Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182 CULLIN, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF74788 SSF74788, 2 hits
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS50069 CULLIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IAU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIVNINFES GWKIIREEAI EKIEKYLENE HIEKNKNLFS ATEYTRLYTV
60 70 80 90 100
VYNMCAKKNP FCYSKEVYRK YGESLSMYTI DKIKPLLKNS DELNKTKILI
110 120 130 140 150
DAWFKYSFYT KWMNKFLRYL DRYYVEYNSS LCLSAYTKNI FKITLFNELR
160 170 180 190 200
EDIKNIIYEI YNNLRLQEEI DQKELFCNIV ELYKELDNES NEKMYEHDIE
210 220 230 240 250
KKIVENVNNF YKKKAEEWIN DYPFDDYIIS IENAIEKEYE KNKSLNLNDD
260 270 280 290 300
TCEKVTNIIV KILIYEKLNT LIDNKNNIFH LLKNNNLSSL RRTYILFSYF
310 320 330 340 350
PEALTGLKKI IGEYIKMEGN ELKDKYVQLS RKMHMSKNVN NMQNVDDNTM
360 370 380 390 400
EDNDNYIDIS NDDNNNNDNS NNNNIMNTEQ NDDIILCDYI EQLIKLHNHY
410 420 430 440 450
DNIFKLSFFN ISNKNIDPNF NECLKDYFES FVEHEDEYFS TVKLLVIYTD
460 470 480 490 500
NILKRDLNNE NSVDEKQKIH MNKEEKNDEQ TKFLMKKMSE IVEIFNYTSN
510 520 530 540 550
KETFFEYYRV YLANRLINNI YISLHIEKKF IEQLYYLCGS QYTSKLGGMI
560 570 580 590 600
QDLINNTNMN NKFYDHMKNV FNNNEIVNNN NNNSIYNDHF SNYHNVKDFF
610 620 630 640 650
SVKILNKGYW PTLEKIHIQL NEPFNKYIQV FEEYYKSENK NRKLEWIYEL
660 670 680 690 700
SEVILHYEFN NILYNLYCNV VNAQILLLFN KYKYINYDIV KNELQIDLKS
710 720 730 740 750
FTDHMYTSFY HFKLITSNDQ IPDWTNSNFY INNNFSYPNK NVYIKKTTAL
760 770 780 790 800
LSKEHEKTKE DRTMAIEAAI VRVMKMHKKL FYDQIFDYVK KSLSSFSPTN
810 820
QVIEKKIDLL VEREYIQKEE NSQIYVYIP
Length:829
Mass (Da):100,272
Last modified:May 5, 2009 - v2
Checksum:i4E63799B4FA991AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA Translation: CAD51265.2
RefSeqiXP_001349416.2, XM_001349380.2

Genome annotation databases

EnsemblProtistsiCAD51265; CAD51265; PF3D7_0811000
GeneDBiPF3D7_0811000.1:pep
GeneIDi2655293
KEGGipfa:PF3D7_0811000

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA Translation: CAD51265.2
RefSeqiXP_001349416.2, XM_001349380.2

3D structure databases

ProteinModelPortaliQ8IAU5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8IAU5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD51265; CAD51265; PF3D7_0811000
GeneDBiPF3D7_0811000.1:pep
GeneIDi2655293
KEGGipfa:PF3D7_0811000

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0811000

Phylogenomic databases

HOGENOMiHOG000280965
InParanoidiQ8IAU5
KOiK03347
OMAiTTHKHIE
PhylomeDBiQ8IAU5

Enzyme and pathway databases

ReactomeiR-PFA-68949 Orc1 removal from chromatin
R-PFA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-PFA-917937 Iron uptake and transport
R-PFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR016159 Cullin_repeat-like_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00888 Cullin, 1 hit
PF10557 Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182 CULLIN, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF74788 SSF74788, 2 hits
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS50069 CULLIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IAU5_PLAF7
AccessioniPrimary (citable) accession number: Q8IAU5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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