PMX

Functionⁱ

During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074775, PubMed:32109369).

Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074775, PubMed:32109369).

May process members of the EBL and Rh protein families (PubMed:32109369).

Also cleaves apical membrane protein AMA1 (PubMed:29074775).

During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (PubMed:29074775).

2 Publications

Activity regulationⁱ

Inhibited by small molecule 49c (PubMed:29074775). Inhibited by small molecules WM382, WM4, and WM5 (PubMed:32109369).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	266	PROSITE-ProRule annotation		1
Active siteⁱ	457	PROSITE-ProRule annotation		1

GO - Molecular functionⁱ

aspartic-type endopeptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.4
  "Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle."
  Favuzza P., de Lera Ruiz M., Thompson J.K., Triglia T., Ngo A., Steel R.W.J., Vavrek M., Christensen J., Healer J., Boyce C., Guo Z., Hu M., Khan T., Murgolo N., Zhao L., Penington J.S., Reaksudsan K., Jarman K.
  Cowman A.F.
  Cell Host Microbe 27:642-658.e12(2020) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, PROTEOLYTIC CLEAVAGE.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aspartyl protease, Hydrolase, Protease

Molecular function

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	A01.A93

MEROPSⁱ

A01.A93

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasmepsin X1 Publication (EC:3.4.23.-2 Publications) Short name: PfPMX1 Publication Alternative name(s): Plasmepsin 10Curated
Gene namesⁱ	Name:PMX1 Publication ORF Names:PF3D7_0808200Imported
Organismⁱ	Plasmodium falciparum (isolate 3D7)Imported
Taxonomic identifierⁱ	36329 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum
Proteomesⁱ	UP000001450 Componentⁱ: Chromosome 8

Organism-specific databases

VEuPathDBⁱ	PlasmoDB:PF3D7_0808200

VEuPathDBⁱ

PlasmoDB:PF3D7_0808200

Keywords - Cellular componentⁱ

Cytoplasmic vesicle

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	266	D → A: Loss of catalytic activity. 1 Publication		1

Chemistry databases

ChEMBLⁱ	CHEMBL4523390

ChEMBLⁱ

CHEMBL4523390

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST	26
PropeptideⁱPRO_0000453739	27 – ?	Curated
ChainⁱPRO_0000453740	? – 573	Plasmepsin XSequence analysis

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	39 ↔ 51	Combined sources1 Publication
Disulfide bondⁱ	42 ↔ 48	Combined sources1 Publication
Disulfide bondⁱ	279 ↔ 284	Combined sources1 Publication
Glycosylationⁱ	334	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	447 ↔ 448	Combined sources1 Publication
Disulfide bondⁱ	482 ↔ 521	Combined sources1 Publication

Post-translational modificationⁱ

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEⁱ	Q8IAS0

PRIDEⁱ

Q8IAS0

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8IAS0, 2 interactors
STRINGⁱ	5833.PF08_0108

Structureⁱ

3D structure databases

SMRⁱ	Q8IAS0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	248 – 567	Peptidase A1PROSITE-ProRule annotationAdd BLAST		320

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	167 – 211	DisorderedSequence analysisAdd BLAST		45

Sequence similaritiesⁱ

Belongs to the peptidase A1 family.UniRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOGENOMⁱ	CLU_500120_0_0_1
InParanoidⁱ	Q8IAS0
OMAⁱ	PQEIHPI
PhylomeDBⁱ	Q8IAS0

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05471, pepsin_like, 1 hit
Gene3Dⁱ	2.40.70.10, 2 hits
InterProⁱ	View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR034164, Pepsin-like_dom IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf
PANTHERⁱ	PTHR47966, PTHR47966, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00026, Asp, 1 hit
PRINTSⁱ	PR00792, PEPSIN
SUPFAMⁱ	SSF50630, SSF50630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00141, ASP_PROTEASE, 1 hit PS51767, PEPTIDASE_A1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8IAS0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRISPLNTL FYLSLFFSYT FKGLKCTRIY KIGTKALPCS ECHDVFDCTG 
        60         70         80         90        100
CLFEEKESSH VIPLKLNKKN PNDHKKLQKH HESLKLGDVK YYVNRGEGIS 
       110        120        130        140        150
GSLGTSSGNT LDDMDLINEE INKKRTNAQL DEKNFLDFTT YNKNKAQDIS 
       160        170        180        190        200
DHLSDIQKHV YEQDAQKGNK NFTNNENNSD NENNSDNENN SDNENNLDNE 
       210        220        230        240        250
NNLDNENNSD NSSIEKNFIA LENKNATVEQ TKENIFLVPL KHLRDSQFVG 
       260        270        280        290        300
ELLVGTPPQT VYPIFDTGST NVWVVTTACE EESCKKVRRY DPNKSKTFRR 
       310        320        330        340        350
SFIEKNLHIV FGSGSISGSV GTDTFMLGKH LVRNQTFGLV ESESNNNKNG 
       360        370        380        390        400
GDNIFDYISF EGIVGLGFPG MLSAGNIPFF DNLLKQNPNV DPQFSFYISP 
       410        420        430        440        450
YDGKSTLIIG GISKSFYEGD IYMLPVLKES YWEVKLDELY IGKERICCDE 
       460        470        480        490        500
ESYVIFDTGT SYNTMPSSQM KTFLNLIHST ACTEQNYKDI LKSYPIIKYV 
       510        520        530        540        550
FGELIIELHP EEYMILNDDV CMPAYMQIDV PSERNHAYLL GSLSFMRNFF 
       560        570 
TVFVRGTESR PSMVGVARAK SKN

Length:573

Mass (Da):65,114

Last modified:March 1, 2003 - v1

Checksum:ⁱ1381CB0D4519A54F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844507 Genomic DNA Translation: CAD51290.1
NCBI Reference Sequences More...RefSeqⁱ	XP_001349441.1, XM_001349405.1

Genome annotation databases

EnsemblProtistsⁱ	CAD51290; CAD51290; PF3D7_0808200
GeneIDⁱ	2655308
KEGGⁱ	pfa:PF3D7_0808200

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IAS0	Plasmepsin X		PLAFO		573	UniRef100_Q8IAS0
Plasmepsin 10		PLAFA		573
Peptidase A1 domain-containing protein		Plasmodium falciparum Vietnam Oak-Knoll (FVO)		573
Plasmepsin 10		Plasmodium falciparum IGH-CR14		573
Peptidase A1 domain-containing protein		Plasmodium falciparum MaliPS096_E11		573

Protein	Similar proteins		Species	Score	Length	Source
Q8IAS0	Plasmepsin X		PLAFO		573	UniRef90_Q8IAS0
Plasmepsin 10		PLAFA		573
Peptidase A1 domain-containing protein		Plasmodium falciparum Vietnam Oak-Knoll (FVO)		573
Plasmepsin 10		Plasmodium falciparum IGH-CR14		573
Peptidase A1 domain-containing protein		Plasmodium falciparum MaliPS096_E11		573
+8

Protein	Similar proteins		Species	Score	Length	Source
Q8IAS0	Plasmepsin X		PLAFO		573	UniRef50_Q8IAS0
Plasmepsin 10		PLAFA		573
Peptidase A1 domain-containing protein		Plasmodium falciparum Vietnam Oak-Knoll (FVO)		573
Plasmepsin 10		Plasmodium falciparum IGH-CR14		573
Peptidase A1 domain-containing protein		Plasmodium falciparum MaliPS096_E11		573
+69

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844507 Genomic DNA Translation: CAD51290.1
RefSeqⁱ	XP_001349441.1, XM_001349405.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6ORS	X-ray	2.30	A	28-573	[»]
SMRⁱ	Q8IAS0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8IAS0, 2 interactors
STRINGⁱ	5833.PF08_0108

Chemistry databases

ChEMBLⁱ	CHEMBL4523390

ChEMBLⁱ

CHEMBL4523390

Protein family/group databases

MEROPSⁱ	A01.A93

MEROPSⁱ

A01.A93

Proteomic databases

PRIDEⁱ	Q8IAS0

PRIDEⁱ

Q8IAS0

Genome annotation databases

EnsemblProtistsⁱ	CAD51290; CAD51290; PF3D7_0808200
GeneIDⁱ	2655308
KEGGⁱ	pfa:PF3D7_0808200

Organism-specific databases

VEuPathDBⁱ	PlasmoDB:PF3D7_0808200

VEuPathDBⁱ

PlasmoDB:PF3D7_0808200

Phylogenomic databases

HOGENOMⁱ	CLU_500120_0_0_1
InParanoidⁱ	Q8IAS0
OMAⁱ	PQEIHPI
PhylomeDBⁱ	Q8IAS0

Family and domain databases

CDDⁱ	cd05471, pepsin_like, 1 hit
Gene3Dⁱ	2.40.70.10, 2 hits
InterProⁱ	View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR034164, Pepsin-like_dom IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf
PANTHERⁱ	PTHR47966, PTHR47966, 1 hit
Pfamⁱ	View protein in Pfam PF00026, Asp, 1 hit
PRINTSⁱ	PR00792, PEPSIN
SUPFAMⁱ	SSF50630, SSF50630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00141, ASP_PROTEASE, 1 hit PS51767, PEPTIDASE_A1, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLM10_PLAF7
Accessionⁱ	Q8IAS0Primary (citable) accession number: Q8IAS0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 29, 2021
	Last sequence update:	March 1, 2003
	Last modified:	February 23, 2022
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

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UniParc

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UniProtKB - Q8IAS0 (PLM10_PLAF7)

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Plasmepsin X

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

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Chemistry databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

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Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ