UniProtKB - Q8IAK2 (Q8IAK2_PLAF7)
Protein
Submitted name:
Erythrocyte membrane protein 1, PfEMP1
Gene
PF3D7_0800200
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
GO - Molecular functioni
- cell adhesion molecule binding Source: GeneDB
- host cell surface receptor binding Source: InterPro
GO - Biological processi
- antigenic variation Source: GeneDB
- cell-cell adhesion Source: GeneDB
- cytoadherence to microvasculature, mediated by symbiont protein Source: GeneDB
- modulation by symbiont of host erythrocyte aggregation Source: GeneDB
- pathogenesis Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Erythrocyte membrane protein 1, PfEMP1Imported |
Gene namesi | ORF Names:PF3D7_0800200Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0800200 |
Subcellular locationi
GO - Cellular componenti
- host cell plasma membrane Source: GeneDB
- infected host cell surface knob Source: GeneDB
- integral component of membrane Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 56 | NTSInterPro annotationAdd BLAST | 36 | |
Domaini | 501 – 550 | CIDR1_gammaInterPro annotationAdd BLAST | 50 | |
Domaini | 566 – 709 | PFEMPInterPro annotationAdd BLAST | 144 | |
Domaini | 2448 – 2858 | ATSInterPro annotationAdd BLAST | 411 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 720 – 758 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 776 – 797 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2387 – 2441 | DisorderedSequence analysisAdd BLAST | 55 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 375 – 395 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2132 – 2152 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2396 – 2419 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 2420 – 2437 | Pro-richSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_000332_0_0_1 |
OMAi | QECENHC |
PhylomeDBi | Q8IAK2 |
Family and domain databases
Gene3Di | 1.20.1310.20, 5 hits |
InterProi | View protein in InterPro IPR041480, CIDR1_gamma IPR004258, DBL IPR042202, Duffy-ag-bd_sf IPR008602, Duffy-antigen-binding IPR029211, PfEMP1_ATS IPR029210, PfEMP1_NTS |
Pfami | View protein in Pfam PF15445, ATS, 1 hit PF18562, CIDR1_gamma, 1 hit PF05424, Duffy_binding, 5 hits PF15447, NTS, 1 hit PF03011, PFEMP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IAK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSQGSKPVD TSDVKNESHN SARNVFENIA EIIYNRVKED AEKRGKSLKG
60 70 80 90 100
DYKRAKFHQP LLEAAKYVWY APSNPCNFDF RFDTNAPDKG SYDRDPCHLR
110 120 130 140 150
DTNRFSDKGD AICTNNKINC NNGGCGACAP YRRIQLCDYN LEYINEYNIN
160 170 180 190 200
STHDLLGNLL VMAKREGDSI VNSHGHTGKG IYKSGICTSL ARSFADIGDI
210 220 230 240 250
IRGKDLFLGH NHKKKPLLDN LEKIFNRFQK IYEDINNLPI DDIREYWWAL
260 270 280 290 300
NRNDVWEALT CSAPYYADYF KKKSGNTYNF TTEGYCGRNE GAPPTNLDYV
310 320 330 340 350
PQFLRWFDEW AEEFCRIKNI KIGNIKKSCT GESNNKHCSR EGYDCNKTNL
360 370 380 390 400
RLNEIFMDLE CPRCADDCKS YETWVENKKK EFNKQKEKYK EEINESKPGV
410 420 430 440 450
NSEHGKYNKA FYDKLRTIYR TNDKFFEILN KGQICENVDE KNKIDFNDLV
460 470 480 490 500
KTFSRSEYCK SCPMLGVTCK GEQCNSLDDI TCTNDKGGPN KVTDKNNNTF
510 520 530 540 550
VIDILLNDNK KKVLSNDLND YKECDLFKRL RRQNWNCKYK CNLHVCELNN
560 570 580 590 600
FNNEIDDERV ISIKVFIKRW LESFLKDYNK LKENLNPCIN NENQLPCIKD
610 620 630 640 650
CLENCDCVEK WIKKKGEEWK KIKERYLKDY KIEDNNSSNS LNKFLQQNQF
660 670 680 690 700
HSDVVKAIKP FENLRAFEDS SGCTGTVPSG IEECKSNDVI KILLSKLKEK
710 720 730 740 750
IELCKKNDVK KNKSNNCVTL LKPLNDEEDD EEQDDEPPAP KPLPTPNPCV
760 770 780 790 800
NGGDDTSGAQ ITSVTEIAEG MHMGAQKQML ERSGDKSGKG TENGESVLKG
810 820 830 840 850
DIKKAKFKNG ASPSSLEDVC GITDQHTKDS RRRRRLRRLR LLVLRFRRRL
860 870 880 890 900
RRGHRDYKGP CTGKDGHKKM FQVEKGWENG SKIGTENDVF LPPRREHFCT
910 920 930 940 950
SNVEHLYRSA SGLQGTTASH SLLGDVLLAA NKEAGFIKER YKTQKTSEGF
960 970 980 990 1000
KDEATVCRAI KYSFADIADI IKGTDLWKAN SGKKNTQDKL VKIFQKIKDN
1010 1020 1030 1040 1050
LPVNIKGKYN EDEKHLELRK DWWFANRDKV WEAMKCEQNG ITCSGPTPLD
1060 1070 1080 1090 1100
DYIPQRLRWM TEWAEWYCKA QKEAYDKLKV CEKCMDNGKC TQGNGECAKC
1110 1120 1130 1140 1150
KTACENYKKF INTWQPQWKQ MEQKYESLYK EAQENGNSSH KSTTEQDKYM
1160 1170 1180 1190 1200
VEFLSQLQKA NNGDKTGDDK VYSTAAGYVH QEATMNCEKQ TQFCKNKNGV
1210 1220 1230 1240 1250
KAANDAEDVN YTFKDTPNGY DVVCKCKDRP EQQIKKKEVE DACKIAQDIF
1260 1270 1280 1290 1300
KGKDENTTVG LCKKKDFGRT PYPDWKCEKN SKLVTGNGEC MPPRRQKLCL
1310 1320 1330 1340 1350
YFLAHKIETP NLNTQEDLRK AFIKCAAAET FFSWYYFKKI NDKLNKLDEK
1360 1370 1380 1390 1400
LKEGEIPPQF LRSMFYTFGD YKDICLDTDI SLKTENGDIT KAKSNIDRII
1410 1420 1430 1440 1450
PKKSAKNPDE ERKIWWDGIK EDVWEGMLCG LSHAVSNNDK ATVQKTLTTK
1460 1470 1480 1490 1500
TIYDYDTVTF DGTTKLEDFS KRPQFLRWMT EWGEEFCKKR KEQLENLKDK
1510 1520 1530 1540 1550
CPDYTCSFDT KKQECENHCK VYEEWLKGWK DQYKKQSEKF TTDKEKPEYK
1560 1570 1580 1590 1600
DDPDVASSEN AHKYLSKKLK QIFHNGSTTE KCDYTCMEYA SRQPQTSACS
1610 1620 1630 1640 1650
QQQQQQNKSS TQNHFPEAFD YPPKEIGDRC TCPKLPEPKY CVDKTAYDIR
1660 1670 1680 1690 1700
KESGKKSDNS LKGNGNTYNN NCNNSMREEY ANQNGETCKF NETFWSKKKP
1710 1720 1730 1740 1750
SIEECDINAK ERFQIQKYWD CNGKTPDGKN TFCIPPRRKD MCLKQLEEIN
1760 1770 1780 1790 1800
SADVNNSKKL LQKIQDVAKK EGDDIIKKLL PKYPCNEDVI CKAMKYSFAD
1810 1820 1830 1840 1850
LADIVRGIDK YKGPNGTNVL EKELKSVFET IYTKWKSENT NNKSKYTDVA
1860 1870 1880 1890 1900
SFRSAWWDAN RKDIWNAMTC NAPYDAKIYI TKEGGYISPL TFTKNKCGHN
1910 1920 1930 1940 1950
DDPPDYDYIP QPFRWLSEWS ETYCLAQKDL LETMKNCENC MKKNKNADCE
1960 1970 1980 1990 2000
QTQYGACRDC KRKCEEYKKF IEIWKKQFET QNKAYQEIYR NATTTNRDNN
2010 2020 2030 2040 2050
NIVDENTKNF VKKLQENCRT DRNESLDTAD KYLENASVCR RFKFGNKDSR
2060 2070 2080 2090 2100
HLNYAFHTDP PSYEEHCKCA KDFDPLDECP VDNNECKKYG IGSCPKKNFH
2110 2120 2130 2140 2150
KKLEEWTNYV LNNKSNKNKS AIVPPRRRQL CLQNLTRNLS RLNKEKSFKE
2160 2170 2180 2190 2200
GILISAASEA KMLTEQYREN PAKALQAIKY SFADIGNIIK GDDIIGNVIS
2210 2220 2230 2240 2250
VQLNKLINGN KKINTSTLWW EANKEKIWNA MMCYYTGDEK TATSCPSHGN
2260 2270 2280 2290 2300
IDKEDQFLLW FQEWGENFCA RQKELYEHVQ AECSHVICVN GTGNIDSKCT
2310 2320 2330 2340 2350
EACKNYSNFI SETKNVYQSL KKQYNDNHNS IKVGGKEVHH YMKEKCKDKC
2360 2370 2380 2390 2400
ECLSEKFNSD NNWEKPYDTF DDTVLKNKCQ CKKPDSPILP VEPSVPAETE
2410 2420 2430 2440 2450
KEKKKDSPLK PHTEPKPAPP KKPEVPPPPP VQPPPANQPF NRDILEKTIP
2460 2470 2480 2490 2500
FGIALALGSI AFLFIKKKPK SPVDLIRVLD IHKGDYGMPT LKSKNRYIPY
2510 2520 2530 2540 2550
ASDTYKGKTY IYMEGDSDSG HYYEDTTDIT SSESEYEEMD INDIYVPDSP
2560 2570 2580 2590 2600
KYKTLIEVVL EPSKRDTPSS DAPMNKFTDD EWNQLKQDFI SGILENEQKD
2610 2620 2630 2640 2650
LPKNNISGNT PMNTQPNTLY FNKPEEKPFI TSIHDRDLYS GEEINYNINM
2660 2670 2680 2690 2700
STNSMDDTSY VSNNVYSGID LINDTLSGNQ HIDIYDEVLK RKENELFGTN
2710 2720 2730 2740 2750
YKKNTSNNNV AKLTNSDPIM NQLDLLHKWL DRHRDMCEKW KSKEDILHKL
2760 2770 2780 2790 2800
NEQWNKDNDG GNVPIDNRSL NTDVWIEIDM DDPKGKKEFS NMDTILDDIE
2810 2820 2830 2840 2850
DDIYYDVNDD ENPSVDNIPM DHNKVDVPKK VHVEMKILNN TSNGSLEPEF
PISDVWNI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844507 Genomic DNA Translation: CAD51362.1 |
RefSeqi | XP_001349513.1, XM_001349477.1 |
Genome annotation databases
EnsemblProtistsi | CAD51362; CAD51362; PF3D7_0800200 |
GeneDBi | PF3D7_0800200.1:pep |
GeneIDi | 2655302 |
KEGGi | pfa:PF3D7_0800200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844507 Genomic DNA Translation: CAD51362.1 |
RefSeqi | XP_001349513.1, XM_001349477.1 |
3D structure databases
SMRi | Q8IAK2 |
ModBasei | Search... |
PTM databases
SwissPalmi | Q8IAK2 |
Proteomic databases
PRIDEi | Q8IAK2 |
Genome annotation databases
EnsemblProtistsi | CAD51362; CAD51362; PF3D7_0800200 |
GeneDBi | PF3D7_0800200.1:pep |
GeneIDi | 2655302 |
KEGGi | pfa:PF3D7_0800200 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0800200 |
Phylogenomic databases
HOGENOMi | CLU_000332_0_0_1 |
OMAi | QECENHC |
PhylomeDBi | Q8IAK2 |
Family and domain databases
Gene3Di | 1.20.1310.20, 5 hits |
InterProi | View protein in InterPro IPR041480, CIDR1_gamma IPR004258, DBL IPR042202, Duffy-ag-bd_sf IPR008602, Duffy-antigen-binding IPR029211, PfEMP1_ATS IPR029210, PfEMP1_NTS |
Pfami | View protein in Pfam PF15445, ATS, 1 hit PF18562, CIDR1_gamma, 1 hit PF05424, Duffy_binding, 5 hits PF15447, NTS, 1 hit PF03011, PFEMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IAK2_PLAF7 | |
Accessioni | Q8IAK2Primary (citable) accession number: Q8IAK2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |