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Entry version 91 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Erythrocyte membrane protein 1, PfEMP1

Gene

PF3D7_0800200

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Erythrocyte membrane protein 1, PfEMP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0800200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0800200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8IAK2

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IAK2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IAK2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 56NTSInterPro annotationAdd BLAST36
Domaini502 – 551CIDR1_gammaInterPro annotationAdd BLAST50
Domaini566 – 709PFEMPInterPro annotationAdd BLAST144
Domaini2448 – 2858ATSInterPro annotationAdd BLAST411

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni720 – 758DisorderedSequence analysisAdd BLAST39
Regioni776 – 797DisorderedSequence analysisAdd BLAST22
Regioni2387 – 2441DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili375 – 395Sequence analysisAdd BLAST21
Coiled coili2132 – 2152Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2396 – 2419PolyampholyteSequence analysisAdd BLAST24
Compositional biasi2420 – 2437Pro-richSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115239

KEGG Orthology (KO)

More...
KOi
K13850

Identification of Orthologs from Complete Genome Data

More...
OMAi
QECENHC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IAK2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1310.20, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041480 CIDR1_gamma
IPR004258 DBL
IPR042202 Duffy-ag-bd_sf
IPR008602 Duffy-antigen_binding
IPR029211 PfEMP1_ATS
IPR029210 PfEMP1_NTS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15445 ATS, 1 hit
PF18562 CIDR1_gamma, 1 hit
PF05424 Duffy_binding, 5 hits
PF15447 NTS, 1 hit
PF03011 PFEMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IAK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSQGSKPVD TSDVKNESHN SARNVFENIA EIIYNRVKED AEKRGKSLKG
60 70 80 90 100
DYKRAKFHQP LLEAAKYVWY APSNPCNFDF RFDTNAPDKG SYDRDPCHLR
110 120 130 140 150
DTNRFSDKGD AICTNNKINC NNGGCGACAP YRRIQLCDYN LEYINEYNIN
160 170 180 190 200
STHDLLGNLL VMAKREGDSI VNSHGHTGKG IYKSGICTSL ARSFADIGDI
210 220 230 240 250
IRGKDLFLGH NHKKKPLLDN LEKIFNRFQK IYEDINNLPI DDIREYWWAL
260 270 280 290 300
NRNDVWEALT CSAPYYADYF KKKSGNTYNF TTEGYCGRNE GAPPTNLDYV
310 320 330 340 350
PQFLRWFDEW AEEFCRIKNI KIGNIKKSCT GESNNKHCSR EGYDCNKTNL
360 370 380 390 400
RLNEIFMDLE CPRCADDCKS YETWVENKKK EFNKQKEKYK EEINESKPGV
410 420 430 440 450
NSEHGKYNKA FYDKLRTIYR TNDKFFEILN KGQICENVDE KNKIDFNDLV
460 470 480 490 500
KTFSRSEYCK SCPMLGVTCK GEQCNSLDDI TCTNDKGGPN KVTDKNNNTF
510 520 530 540 550
VIDILLNDNK KKVLSNDLND YKECDLFKRL RRQNWNCKYK CNLHVCELNN
560 570 580 590 600
FNNEIDDERV ISIKVFIKRW LESFLKDYNK LKENLNPCIN NENQLPCIKD
610 620 630 640 650
CLENCDCVEK WIKKKGEEWK KIKERYLKDY KIEDNNSSNS LNKFLQQNQF
660 670 680 690 700
HSDVVKAIKP FENLRAFEDS SGCTGTVPSG IEECKSNDVI KILLSKLKEK
710 720 730 740 750
IELCKKNDVK KNKSNNCVTL LKPLNDEEDD EEQDDEPPAP KPLPTPNPCV
760 770 780 790 800
NGGDDTSGAQ ITSVTEIAEG MHMGAQKQML ERSGDKSGKG TENGESVLKG
810 820 830 840 850
DIKKAKFKNG ASPSSLEDVC GITDQHTKDS RRRRRLRRLR LLVLRFRRRL
860 870 880 890 900
RRGHRDYKGP CTGKDGHKKM FQVEKGWENG SKIGTENDVF LPPRREHFCT
910 920 930 940 950
SNVEHLYRSA SGLQGTTASH SLLGDVLLAA NKEAGFIKER YKTQKTSEGF
960 970 980 990 1000
KDEATVCRAI KYSFADIADI IKGTDLWKAN SGKKNTQDKL VKIFQKIKDN
1010 1020 1030 1040 1050
LPVNIKGKYN EDEKHLELRK DWWFANRDKV WEAMKCEQNG ITCSGPTPLD
1060 1070 1080 1090 1100
DYIPQRLRWM TEWAEWYCKA QKEAYDKLKV CEKCMDNGKC TQGNGECAKC
1110 1120 1130 1140 1150
KTACENYKKF INTWQPQWKQ MEQKYESLYK EAQENGNSSH KSTTEQDKYM
1160 1170 1180 1190 1200
VEFLSQLQKA NNGDKTGDDK VYSTAAGYVH QEATMNCEKQ TQFCKNKNGV
1210 1220 1230 1240 1250
KAANDAEDVN YTFKDTPNGY DVVCKCKDRP EQQIKKKEVE DACKIAQDIF
1260 1270 1280 1290 1300
KGKDENTTVG LCKKKDFGRT PYPDWKCEKN SKLVTGNGEC MPPRRQKLCL
1310 1320 1330 1340 1350
YFLAHKIETP NLNTQEDLRK AFIKCAAAET FFSWYYFKKI NDKLNKLDEK
1360 1370 1380 1390 1400
LKEGEIPPQF LRSMFYTFGD YKDICLDTDI SLKTENGDIT KAKSNIDRII
1410 1420 1430 1440 1450
PKKSAKNPDE ERKIWWDGIK EDVWEGMLCG LSHAVSNNDK ATVQKTLTTK
1460 1470 1480 1490 1500
TIYDYDTVTF DGTTKLEDFS KRPQFLRWMT EWGEEFCKKR KEQLENLKDK
1510 1520 1530 1540 1550
CPDYTCSFDT KKQECENHCK VYEEWLKGWK DQYKKQSEKF TTDKEKPEYK
1560 1570 1580 1590 1600
DDPDVASSEN AHKYLSKKLK QIFHNGSTTE KCDYTCMEYA SRQPQTSACS
1610 1620 1630 1640 1650
QQQQQQNKSS TQNHFPEAFD YPPKEIGDRC TCPKLPEPKY CVDKTAYDIR
1660 1670 1680 1690 1700
KESGKKSDNS LKGNGNTYNN NCNNSMREEY ANQNGETCKF NETFWSKKKP
1710 1720 1730 1740 1750
SIEECDINAK ERFQIQKYWD CNGKTPDGKN TFCIPPRRKD MCLKQLEEIN
1760 1770 1780 1790 1800
SADVNNSKKL LQKIQDVAKK EGDDIIKKLL PKYPCNEDVI CKAMKYSFAD
1810 1820 1830 1840 1850
LADIVRGIDK YKGPNGTNVL EKELKSVFET IYTKWKSENT NNKSKYTDVA
1860 1870 1880 1890 1900
SFRSAWWDAN RKDIWNAMTC NAPYDAKIYI TKEGGYISPL TFTKNKCGHN
1910 1920 1930 1940 1950
DDPPDYDYIP QPFRWLSEWS ETYCLAQKDL LETMKNCENC MKKNKNADCE
1960 1970 1980 1990 2000
QTQYGACRDC KRKCEEYKKF IEIWKKQFET QNKAYQEIYR NATTTNRDNN
2010 2020 2030 2040 2050
NIVDENTKNF VKKLQENCRT DRNESLDTAD KYLENASVCR RFKFGNKDSR
2060 2070 2080 2090 2100
HLNYAFHTDP PSYEEHCKCA KDFDPLDECP VDNNECKKYG IGSCPKKNFH
2110 2120 2130 2140 2150
KKLEEWTNYV LNNKSNKNKS AIVPPRRRQL CLQNLTRNLS RLNKEKSFKE
2160 2170 2180 2190 2200
GILISAASEA KMLTEQYREN PAKALQAIKY SFADIGNIIK GDDIIGNVIS
2210 2220 2230 2240 2250
VQLNKLINGN KKINTSTLWW EANKEKIWNA MMCYYTGDEK TATSCPSHGN
2260 2270 2280 2290 2300
IDKEDQFLLW FQEWGENFCA RQKELYEHVQ AECSHVICVN GTGNIDSKCT
2310 2320 2330 2340 2350
EACKNYSNFI SETKNVYQSL KKQYNDNHNS IKVGGKEVHH YMKEKCKDKC
2360 2370 2380 2390 2400
ECLSEKFNSD NNWEKPYDTF DDTVLKNKCQ CKKPDSPILP VEPSVPAETE
2410 2420 2430 2440 2450
KEKKKDSPLK PHTEPKPAPP KKPEVPPPPP VQPPPANQPF NRDILEKTIP
2460 2470 2480 2490 2500
FGIALALGSI AFLFIKKKPK SPVDLIRVLD IHKGDYGMPT LKSKNRYIPY
2510 2520 2530 2540 2550
ASDTYKGKTY IYMEGDSDSG HYYEDTTDIT SSESEYEEMD INDIYVPDSP
2560 2570 2580 2590 2600
KYKTLIEVVL EPSKRDTPSS DAPMNKFTDD EWNQLKQDFI SGILENEQKD
2610 2620 2630 2640 2650
LPKNNISGNT PMNTQPNTLY FNKPEEKPFI TSIHDRDLYS GEEINYNINM
2660 2670 2680 2690 2700
STNSMDDTSY VSNNVYSGID LINDTLSGNQ HIDIYDEVLK RKENELFGTN
2710 2720 2730 2740 2750
YKKNTSNNNV AKLTNSDPIM NQLDLLHKWL DRHRDMCEKW KSKEDILHKL
2760 2770 2780 2790 2800
NEQWNKDNDG GNVPIDNRSL NTDVWIEIDM DDPKGKKEFS NMDTILDDIE
2810 2820 2830 2840 2850
DDIYYDVNDD ENPSVDNIPM DHNKVDVPKK VHVEMKILNN TSNGSLEPEF

PISDVWNI
Length:2,858
Mass (Da):330,697
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0170B3E07C7200B0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844507 Genomic DNA Translation: CAD51362.1

NCBI Reference Sequences

More...
RefSeqi
XP_001349513.1, XM_001349477.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD51362; CAD51362; PF3D7_0800200

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0800200.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2655302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0800200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA Translation: CAD51362.1
RefSeqiXP_001349513.1, XM_001349477.1

3D structure databases

SMRiQ8IAK2
ModBaseiSearch...

PTM databases

SwissPalmiQ8IAK2

Proteomic databases

PRIDEiQ8IAK2

Genome annotation databases

EnsemblProtistsiCAD51362; CAD51362; PF3D7_0800200
GeneDBiPF3D7_0800200.1:pep
GeneIDi2655302
KEGGipfa:PF3D7_0800200

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0800200

Phylogenomic databases

HOGENOMiHOG000115239
KOiK13850
OMAiQECENHC
PhylomeDBiQ8IAK2

Family and domain databases

Gene3Di1.20.1310.20, 5 hits
InterProiView protein in InterPro
IPR041480 CIDR1_gamma
IPR004258 DBL
IPR042202 Duffy-ag-bd_sf
IPR008602 Duffy-antigen_binding
IPR029211 PfEMP1_ATS
IPR029210 PfEMP1_NTS
PfamiView protein in Pfam
PF15445 ATS, 1 hit
PF18562 CIDR1_gamma, 1 hit
PF05424 Duffy_binding, 5 hits
PF15447 NTS, 1 hit
PF03011 PFEMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IAK2_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IAK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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