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Protein

Metallothionein-4

Gene

MtnD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity).By similarity

GO - Molecular functioni

  • metal ion binding Source: FlyBase

GO - Biological processi

  • metal ion homeostasis Source: FlyBase
  • response to copper ion Source: FlyBase
  • response to metal ion Source: FlyBase

Keywordsi

LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein D
Gene namesi
Name:MtnD
ORF Names:CG33192
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0053192 MtnD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973571 – 44Metallothionein-4Add BLAST44

Proteomic databases

PaxDbiQ8I9B4
PRIDEiQ8I9B4

Expressioni

Gene expression databases

BgeeiFBgn0053192 Expressed in 16 organ(s), highest expression level in adult midgut (Drosophila)
GenevisibleiQ8I9B4 DM

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0300409

Structurei

3D structure databases

SMRiQ8I9B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KBV5 Eukaryota
ENOG4110MWJ LUCA
InParanoidiQ8I9B4
PhylomeDBiQ8I9B4

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA

Sequencei

Sequence statusi: Complete.

Q8I9B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MGCKACGTNC QCSATKCGDN CACSQQCQCS CKNGPKDKCC STKN
Length:44
Mass (Da):4,545
Last modified:March 1, 2003 - v1
Checksum:i34F0847BFA8BCC7B
GO

Sequence cautioni

The sequence ABE01242 differs from that shown. Reason: Erroneous termination at position 32. Translated as Lys.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546903 mRNA Translation: AAN73050.1
AE014297 Genomic DNA Translation: AAO41579.2
BT025012 mRNA Translation: ABE01242.1 Sequence problems.
RefSeqiNP_788695.2, NM_176518.2
UniGeneiDm.14852

Genome annotation databases

EnsemblMetazoaiFBtr0308064; FBpp0300409; FBgn0053192
GeneIDi326270
KEGGidme:Dmel_CG33192

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF546903 mRNA Translation: AAN73050.1
AE014297 Genomic DNA Translation: AAO41579.2
BT025012 mRNA Translation: ABE01242.1 Sequence problems.
RefSeqiNP_788695.2, NM_176518.2
UniGeneiDm.14852

3D structure databases

SMRiQ8I9B4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0300409

Proteomic databases

PaxDbiQ8I9B4
PRIDEiQ8I9B4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0308064; FBpp0300409; FBgn0053192
GeneIDi326270
KEGGidme:Dmel_CG33192

Organism-specific databases

CTDi326270
FlyBaseiFBgn0053192 MtnD

Phylogenomic databases

eggNOGiENOG410KBV5 Eukaryota
ENOG4110MWJ LUCA
InParanoidiQ8I9B4
PhylomeDBiQ8I9B4

Miscellaneous databases

GenomeRNAii326270
PROiPR:Q8I9B4

Gene expression databases

BgeeiFBgn0053192 Expressed in 16 organ(s), highest expression level in adult midgut (Drosophila)
GenevisibleiQ8I9B4 DM

Family and domain databases

InterProiView protein in InterPro
IPR000966 Metalthion_5
PfamiView protein in Pfam
PF02067 Metallothio_5, 1 hit
PRINTSiPR00872 MTDIPTERA
ProtoNetiSearch...

Entry informationi

Entry nameiMT4_DROME
AccessioniPrimary (citable) accession number: Q8I9B4
Secondary accession number(s): Q1WW94, Q86B88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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