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Protein

Retrovirus-related Pol polyprotein from transposon opus

Gene

pol

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon opus
Including the following 3 domains:
Protease (EC:3.4.23.-)
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pol
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025875 opus\pol

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001995591 – 1003Retrovirus-related Pol polyprotein from transposon opusAdd BLAST1003

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
Q8I7P9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8I7P9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8I7P9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 331Reverse transcriptasePROSITE-ProRule annotationAdd BLAST185
Domaini752 – 910Integrase catalyticPROSITE-ProRule annotationAdd BLAST159

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001584 Integrase_cat-core
IPR021109 Peptidase_aspartic_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00665 rve, 1 hit
PF00078 RVT_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I7P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITHRLVGKF FKPLGNDSDI TFFVLPNLHS FDGIIGDDTL KDLKAIVDRK
60 70 80 90 100
NNCLIITPGI KIPLLARASI NVNPLLAAEH PDGTQEILNS LLGEFPRIFE
110 120 130 140 150
PPLSGMSVET AVKAEIRTNT QDPIYAKSYP YPVNMRGEVE RQIDELLQDG
160 170 180 190 200
IIRPSNSPYN SPIWIVPKKP KPNGEKQYRM VVDFKRLNTV TIPDTYPIPD
210 220 230 240 250
INATLASLGN AKYFTTLDLT SGFHQIHMKE SDIPKTAFST LNGKYEFLRL
260 270 280 290 300
PFGLKNAPAI FQRMIDDILR EHIGKVCYVY IDDIIVFSED YDTHWKNLRL
310 320 330 340 350
VLASLSKANL QVNLEKSHFL DTQVEFLGYI VTADGIKADP KKVRAISEMP
360 370 380 390 400
PPTSVKELKR FLGMTSYYRK FIQDYAKVAK PLTNLTRGLY ANIKSSQSSK
410 420 430 440 450
VPITLDETAL QSFNDLKSIL CSSEILAFPC FTKPFHLTTD ASNWAIGAVL
460 470 480 490 500
SQDDQGRDRP IAYISRSLNK TEENYATIEK EMLAIIWSLD NLRAYLYGAG
510 520 530 540 550
TIKVYTDHQP LTFALGNRNF NAKLKRWKAR IEEYNCELIY KPGKSNVVAD
560 570 580 590 600
ALSRIPPQLN QLSTDLDANP EDDMQSLATA HSALHDSSRL IPHVESPINV
610 620 630 640 650
FKNQLIFDTT RSKYLCEHPF PGYTRHLIPL KDGSLADLTN SLQSCLRPVI
660 670 680 690 700
INGVKIPEAH LQRFQSICLA NFLLYKIRIT QRLVADVSGA EEICEIIEKE
710 720 730 740 750
HRRAHRGPTE IRLQLLEKYY FPRMSSTIRL QTSSCQCCKL YKYERHPNKP
760 770 780 790 800
NLQPTPIPNY PCEILHIDIF ALEKRLYLSC IDKFSKFAKL FHLQSKASVH
810 820 830 840 850
LRETLVEALH YFTAPKVLVS DNERGLLCPT VLNYLRSLDI DLYYAPTQKS
860 870 880 890 900
EVNGQVERFH STFLEIYRCL KDELPTFKPV ELVHIAVDRY NTSVHSVTNR
910 920 930 940 950
KPADVFFDRS SRVNYQGLTD FRRQTLEDIK GLIEYKQIRG NMARNKNRDE
960 970 980 990 1000
PKSYGPGDEV FVANKQIKTK EKARFRCEKV QEDNKITVKT RSGKIFHKSD

LRN
Length:1,003
Mass (Da):114,635
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC28AA23D6CEB8655
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY180918 Genomic DNA Translation: AAN87271.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180918 Genomic DNA Translation: AAN87271.1

3D structure databases

ProteinModelPortaliQ8I7P9
SMRiQ8I7P9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8I7P9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0025875 opus\pol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8I7P9

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001584 Integrase_cat-core
IPR021109 Peptidase_aspartic_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom
PfamiView protein in Pfam
PF00665 rve, 1 hit
PF00078 RVT_1, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL5_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I7P9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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