UniProtKB - Q8I719 (Q8I719_PLAF7)

BLAST

>tr|Q8I719|Q8I719_PLAF7 cGMP-dependent protein kinase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1436600 PE=1 SV=1
MEEDDNLKKGNERNKKKAIFSNDDFTGEDSLMEDHLELREKLSEDIDMIKTSLKNNLVCS
TLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSS
FGEAALIHNTQRSATIIAETDGTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDML
TEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEKGSYFG
ERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFKQFS
GDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLDDTSIGILSRGMSFG
DQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGNNNIDASIDYNNKKSIIKKMYIFR
YLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDY
FGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDE
LETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPF
IIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNI
VYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGCTVDIW
ALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQG
RIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQIEEEDAEDDE
EPLNDEDNWDIDF

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History
Entry version 127 (12 Sep 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Submitted name:

cGMP-dependent protein kinase

Gene

PF3D7_1436600

Organism

Plasmodium falciparum (isolate 3D7)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cGMP-dependent protein kinase activity
Source: GeneDB
Inferred from direct assayⁱ
- 12068803

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein phosphorylation
Source: GeneDB
Inferred from direct assayⁱ
- 12068803

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
Ligand	ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-PFA-163615 PKA activation R-PFA-164378 PKA activation in glucagon signalling R-PFA-180024 DARPP-32 events R-PFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-PFA-5610787 Hedgehog 'off' state

Reactomeⁱ

R-PFA-163615 PKA activation
R-PFA-164378 PKA activation in glucagon signalling
R-PFA-180024 DARPP-32 events
R-PFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-PFA-5610787 Hedgehog 'off' state

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cGMP-dependent protein kinaseImported (EC:2.7.11.12Imported)
Gene namesⁱ	ORF Names:PF3D7_1436600Imported
Organismⁱ	Plasmodium falciparum (isolate 3D7)Imported
Taxonomic identifierⁱ	36329 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum
Proteomesⁱ	UP000001450 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	PlasmoDB:PF3D7_1436600

EuPathDBⁱ

PlasmoDB:PF3D7_1436600

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm
Source: GeneDB
Inferred from direct assayⁱ
- 23139764
endoplasmic reticulum
Source: GeneDB
Inferred from direct assayⁱ
- 23139764
extrinsic component of membrane
Source: GeneDB
Inferred from direct assayⁱ
- 23139764

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q8I719

PRIDEⁱ

Q8I719

Structureⁱ

3D structure databases

SMRⁱ	Q8I719
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K07376
OMAⁱ	ELQSKCI

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00038 CAP_ED, 4 hits cd05572 STKc_cGK, 1 hit
Gene3Dⁱ	2.60.120.10, 4 hits
InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR002374 cGMP_dep_kinase IPR018490 cNMP-bd-like IPR018488 cNMP-bd_CS IPR000595 cNMP-bd_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR014710 RmlC-like_jellyroll IPR008271 Ser/Thr_kinase_AS IPR035014 STKc_cGK
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027 cNMP_binding, 3 hits PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF000559 cGMP-dep_kinase, 2 hits
SMARTⁱ	View protein in SMART SM00100 cNMP, 4 hits SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF51206 SSF51206, 4 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00888 CNMP_BINDING_1, 3 hits PS00889 CNMP_BINDING_2, 3 hits PS50042 CNMP_BINDING_3, 4 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8I719-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEEDDNLKKG NERNKKKAIF SNDDFTGEDS LMEDHLELRE KLSEDIDMIK 
        60         70         80         90        100
TSLKNNLVCS TLNDNEILTL SNYMQFFVFK SGNLVIKQGE KGSYFFIINS 
       110        120        130        140        150
GKFDVYVNDK KVKTMGKGSS FGEAALIHNT QRSATIIAET DGTLWGVQRS 
       160        170        180        190        200
TFRATLKQLS NRNFNENRTF IDSVSVFDML TEAQKNMITN ACVIQNFKSG 
       210        220        230        240        250
ETIVKQGDYG DVLYILKEGK ATVYINDEEI RVLEKGSYFG ERALLYDEPR 
       260        270        280        290        300
SATIIAKEPT ACASICRKLL NIVLGNLQVV LFRNIMTEAL QQSEIFKQFS 
       310        320        330        340        350
GDQLNDLADT AIVRDYPANY NILHKDKVKS VKYIIVLEGK VELFLDDTSI 
       360        370        380        390        400
GILSRGMSFG DQYVLNQKQP FKHTIKSLEV CKIALITETC LADCLGNNNI 
       410        420        430        440        450
DASIDYNNKK SIIKKMYIFR YLTDKQCNLL IEAFRTTRYE EGDYIIQEGE 
       460        470        480        490        500
VGSRFYIIKN GEVEIVKNKK RLRTLGKNDY FGERALLYDE PRTASVISKV 
       510        520        530        540        550
NNVECWFVDK SVFLQIIQGP MLAHLEERIK MQDTKVEMDE LETERIIGRG 
       560        570        580        590        600
TFGTVKLVHH KPTKIRYALK CVSKRSIINL NQQNNIKLER EITAENDHPF 
       610        620        630        640        650
IIRLVRTFKD SKYFYFLTEL VTGGELYDAI RKLGLLSKSQ AQFYLGSIIL 
       660        670        680        690        700
AIEYLHERNI VYRDLKPENI LLDKQGYVKL IDFGCAKKVQ GRAYTLVGTP 
       710        720        730        740        750
HYMAPEVILG KGYGCTVDIW ALGICLYEFI CGPLPFGNDE EDQLEIFRDI 
       760        770        780        790        800
LTGQLTFPDY VTDTDSINLM KRLLCRLPQG RIGCSINGFK DIKDHPFFSN 
       810        820        830        840        850
FNWDKLAGRL LDPPLVSKSE TYAEDIDIKQ IEEEDAEDDE EPLNDEDNWD 

IDF

Length:853

Mass (Da):97,694

Last modified:March 1, 2003 - v1

Checksum:ⁱDBBB189707A480E2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LN999946 Genomic DNA Translation: CZU00064.1
NCBI Reference Sequences More...RefSeqⁱ	XP_001348520.1, XM_001348484.1

Genome annotation databases

EnsemblProtistsⁱ	CZU00064; CZU00064; PF3D7_1436600
GeneDBⁱ	PF3D7_1436600.1:pep
GeneIDⁱ	811928
KEGGⁱ	pfa:PF3D7_1436600

Protein	Similar proteins		Species	Score	Length	Source
Q8I719	Uncharacterized protein		PLAF4		853	UniRef100_A0A0L7M3I6
AGC/AGC-SAR/CILIATE-E2B protein kinase		Plasmodium falciparum UGT5.1		853
Uncharacterized protein		PLAFX		853
cGMP-dependent protein kinase	)	PLAFA		853
Other/ciliate-e2/ciliate-e2b protein kinase		Plasmodium falciparum IGH-CR14		853
+2

Protein	Similar proteins		Species	Score	Length	Source
Q8I719	cGMP-dependent protein kinase, putative		PLAKH		854	UniRef90_A0A1A7VUR3
Putative cGMP-dependent protein kinase		PLAKN		854
AGC/AGC-SAR/CILIATE-E2B protein kinase		PLAFR		889
cGMP-dependent protein kinase		PLAGO		857
AGC/AGC-SAR/CILIATE-E2B protein kinase		Plasmodium falciparum NF135/5.C10		856
+38

Protein	Similar proteins		Species	Score	Length	Source
Q8I719	cGMP-dependent protein kinase, putative		PLAKH		854	UniRef50_A0A1A7VUR3
Putative cGMP-dependent protein kinase		PLAKN		854
AGC/AGC-SAR/CILIATE-E2B protein kinase		PLAFR		889
cGMP-dependent protein kinase		PLAGO		857
cGMP-dependent protein kinase		Plasmodium coatneyi		856
+59

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LN999946 Genomic DNA Translation: CZU00064.1
RefSeqⁱ	XP_001348520.1, XM_001348484.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4OFG	X-ray	2.00	A	401-542	[»]
	5E16	X-ray	1.65	A	21-162	[»]
SMRⁱ	Q8I719
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q8I719

PRIDEⁱ

Q8I719

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	CZU00064; CZU00064; PF3D7_1436600
GeneDBⁱ	PF3D7_1436600.1:pep
GeneIDⁱ	811928
KEGGⁱ	pfa:PF3D7_1436600

Organism-specific databases

EuPathDBⁱ	PlasmoDB:PF3D7_1436600

EuPathDBⁱ

PlasmoDB:PF3D7_1436600

Phylogenomic databases

KOⁱ	K07376
OMAⁱ	ELQSKCI

Enzyme and pathway databases

Reactomeⁱ	R-PFA-163615 PKA activation R-PFA-164378 PKA activation in glucagon signalling R-PFA-180024 DARPP-32 events R-PFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-PFA-5610787 Hedgehog 'off' state

Reactomeⁱ

Family and domain databases

CDDⁱ	cd00038 CAP_ED, 4 hits cd05572 STKc_cGK, 1 hit
Gene3Dⁱ	2.60.120.10, 4 hits
InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR002374 cGMP_dep_kinase IPR018490 cNMP-bd-like IPR018488 cNMP-bd_CS IPR000595 cNMP-bd_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR014710 RmlC-like_jellyroll IPR008271 Ser/Thr_kinase_AS IPR035014 STKc_cGK
Pfamⁱ	View protein in Pfam PF00027 cNMP_binding, 3 hits PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF000559 cGMP-dep_kinase, 2 hits
SMARTⁱ	View protein in SMART SM00100 cNMP, 4 hits SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF51206 SSF51206, 4 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00888 CNMP_BINDING_1, 3 hits PS00889 CNMP_BINDING_2, 3 hits PS50042 CNMP_BINDING_3, 4 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8I719_PLAF7
Accessionⁱ	Q8I719Primary (citable) accession number: Q8I719
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2003
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB - Q8I719 (Q8I719_PLAF7)

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cGMP-dependent protein kinase

PF3D7_1436600

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8I719 (Q8I719_PLAF7)

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cGMP-dependent protein kinase

PF3D7_1436600

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ