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Protein
Submitted name:

cGMP-dependent protein kinase

Gene

PF3D7_1436600

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cGMP-dependent protein kinase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-163615 PKA activation
R-PFA-164378 PKA activation in glucagon signalling
R-PFA-180024 DARPP-32 events
R-PFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-PFA-5610787 Hedgehog 'off' state

Names & Taxonomyi

Protein namesi
Submitted name:
cGMP-dependent protein kinaseImported (EC:2.7.11.12Imported)
Gene namesi
ORF Names:PF3D7_1436600Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1436600

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PRIDEiQ8I719

Structurei

3D structure databases

SMRiQ8I719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK07376
OMAiELQSKCI

Family and domain databases

CDDicd00038 CAP_ED, 4 hits
cd05572 STKc_cGK, 1 hit
Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR002374 cGMP_dep_kinase
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR014710 RmlC-like_jellyroll
IPR008271 Ser/Thr_kinase_AS
IPR035014 STKc_cGK
PfamiView protein in Pfam
PF00027 cNMP_binding, 3 hits
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000559 cGMP-dep_kinase, 2 hits
SMARTiView protein in SMART
SM00100 cNMP, 4 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF51206 SSF51206, 4 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00888 CNMP_BINDING_1, 3 hits
PS00889 CNMP_BINDING_2, 3 hits
PS50042 CNMP_BINDING_3, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8I719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEDDNLKKG NERNKKKAIF SNDDFTGEDS LMEDHLELRE KLSEDIDMIK
60 70 80 90 100
TSLKNNLVCS TLNDNEILTL SNYMQFFVFK SGNLVIKQGE KGSYFFIINS
110 120 130 140 150
GKFDVYVNDK KVKTMGKGSS FGEAALIHNT QRSATIIAET DGTLWGVQRS
160 170 180 190 200
TFRATLKQLS NRNFNENRTF IDSVSVFDML TEAQKNMITN ACVIQNFKSG
210 220 230 240 250
ETIVKQGDYG DVLYILKEGK ATVYINDEEI RVLEKGSYFG ERALLYDEPR
260 270 280 290 300
SATIIAKEPT ACASICRKLL NIVLGNLQVV LFRNIMTEAL QQSEIFKQFS
310 320 330 340 350
GDQLNDLADT AIVRDYPANY NILHKDKVKS VKYIIVLEGK VELFLDDTSI
360 370 380 390 400
GILSRGMSFG DQYVLNQKQP FKHTIKSLEV CKIALITETC LADCLGNNNI
410 420 430 440 450
DASIDYNNKK SIIKKMYIFR YLTDKQCNLL IEAFRTTRYE EGDYIIQEGE
460 470 480 490 500
VGSRFYIIKN GEVEIVKNKK RLRTLGKNDY FGERALLYDE PRTASVISKV
510 520 530 540 550
NNVECWFVDK SVFLQIIQGP MLAHLEERIK MQDTKVEMDE LETERIIGRG
560 570 580 590 600
TFGTVKLVHH KPTKIRYALK CVSKRSIINL NQQNNIKLER EITAENDHPF
610 620 630 640 650
IIRLVRTFKD SKYFYFLTEL VTGGELYDAI RKLGLLSKSQ AQFYLGSIIL
660 670 680 690 700
AIEYLHERNI VYRDLKPENI LLDKQGYVKL IDFGCAKKVQ GRAYTLVGTP
710 720 730 740 750
HYMAPEVILG KGYGCTVDIW ALGICLYEFI CGPLPFGNDE EDQLEIFRDI
760 770 780 790 800
LTGQLTFPDY VTDTDSINLM KRLLCRLPQG RIGCSINGFK DIKDHPFFSN
810 820 830 840 850
FNWDKLAGRL LDPPLVSKSE TYAEDIDIKQ IEEEDAEDDE EPLNDEDNWD

IDF
Length:853
Mass (Da):97,694
Last modified:March 1, 2003 - v1
Checksum:iDBBB189707A480E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00064.1
RefSeqiXP_001348520.1, XM_001348484.1

Genome annotation databases

EnsemblProtistsiCZU00064; CZU00064; PF3D7_1436600
GeneDBiPF3D7_1436600.1:pep
GeneIDi811928
KEGGipfa:PF3D7_1436600

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00064.1
RefSeqiXP_001348520.1, XM_001348484.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OFGX-ray2.00A401-542[»]
5E16X-ray1.65A21-162[»]
SMRiQ8I719
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8I719

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZU00064; CZU00064; PF3D7_1436600
GeneDBiPF3D7_1436600.1:pep
GeneIDi811928
KEGGipfa:PF3D7_1436600

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1436600

Phylogenomic databases

KOiK07376
OMAiELQSKCI

Enzyme and pathway databases

ReactomeiR-PFA-163615 PKA activation
R-PFA-164378 PKA activation in glucagon signalling
R-PFA-180024 DARPP-32 events
R-PFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-PFA-5610787 Hedgehog 'off' state

Family and domain databases

CDDicd00038 CAP_ED, 4 hits
cd05572 STKc_cGK, 1 hit
Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR002374 cGMP_dep_kinase
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR014710 RmlC-like_jellyroll
IPR008271 Ser/Thr_kinase_AS
IPR035014 STKc_cGK
PfamiView protein in Pfam
PF00027 cNMP_binding, 3 hits
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000559 cGMP-dep_kinase, 2 hits
SMARTiView protein in SMART
SM00100 cNMP, 4 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF51206 SSF51206, 4 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00888 CNMP_BINDING_1, 3 hits
PS00889 CNMP_BINDING_2, 3 hits
PS50042 CNMP_BINDING_3, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8I719_PLAF7
AccessioniPrimary (citable) accession number: Q8I719
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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