UniProtKB - Q8I6Z5 (Q8I6Z5_PLAF7)
Protein
Submitted name:
Plasmepsin V
Gene
PF3D7_1323500
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: GeneDB
GO - Biological processi
- proteolysis Source: GeneDB
Keywordsi
Molecular function | Aspartyl proteaseUniRule annotation, Hydrolase, Protease |
Enzyme and pathway databases
Reactomei | R-PFA-2132295, MHC class II antigen presentation R-PFA-6798695, Neutrophil degranulation |
Protein family/group databases
MEROPSi | A01.075 |
TCDBi | 8.A.32.1.6, the Beta-amyloid cleaving enzyme (bace1) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1323500Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1323500 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 31 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 546 – 567 | HelicalSequence analysisAdd BLAST | 22 |
GO - Cellular componenti
- endoplasmic reticulum Source: GeneDB
- integral component of membrane Source: GeneDB
Keywords - Cellular componenti
MembranePathology & Biotechi
Miscellaneous databases
PHI-basei | PHI:8625 |
Chemistry databases
ChEMBLi | CHEMBL3559649 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 100 – 514 | Peptidase A1InterPro annotationAdd BLAST | 415 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 282 – 316 | DisorderedSequence analysisAdd BLAST | 35 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 33 – 81 | Sequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_526282_0_0_1 |
InParanoidi | Q8I6Z5 |
OMAi | PFNLNNS |
Family and domain databases
CDDi | cd06096, Plasmepsin_5, 1 hit |
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf IPR033866, Plasmepsin_5 IPR032861, TAXi_N |
PANTHERi | PTHR13683, PTHR13683, 1 hit |
Pfami | View protein in Pfam PF00026, Asp, 1 hit PF14543, TAXi_N, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS00141, ASP_PROTEASE, 1 hit PS51767, PEPTIDASE_A1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I6Z5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNYFLRKEN FFILFCFVFV SIFFVSNVTI IKCNNVENKI DNVGKKIENV
60 70 80 90 100
GKKIGDMENK NDNVENKNDN VGNKNDNVKN ASSDLYKYKL YGDIDEYAYY
110 120 130 140 150
FLDIDIGKPS QRISLILDTG SSSLSFPCNG CKDCGIHMEK PYNLNYSKTS
160 170 180 190 200
SILYCNKSNC PYGLKCVGNK CEYLQSYCEG SQIYGFYFSD IVTLPSYNNK
210 220 230 240 250
NKISFEKLMG CHMHEESLFL HQQATGVLGF SLTKPNGVPT FVDLLFKHTP
260 270 280 290 300
SLKPIYSICV SEHGGELIIG GYEPDYFLSN QKEKQKMDKS DNNSSNKGNV
310 320 330 340 350
SIKLKNNDKN DDEENNSKDV IVSNNVEDIV WQAITRKYYY YIKIYGLDLY
360 370 380 390 400
GTNIMDKKEL DMLVDSGSTF THIPENIYNQ INYYLDILCI HDMTNIYEIN
410 420 430 440 450
KRLKLTNESL NKPLVYFEDF KTALKNIIQN ENLCIKIVDG VQCWKSLENL
460 470 480 490 500
PNLYITLSNN YKMIWKPSSY LYKKESFWCK GLEKQVNNKP ILGLTFFKNK
510 520 530 540 550
QVIFDLQQNQ IAFIESKCPS NLTSSRPRTF NEYREKENIF LKVSYINLYC
560 570 580 590
LWLLLALTIL LSLILYVRKM FYMDYFPLSD QNKSPIQEST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844509 Genomic DNA Translation: CAD52383.1 |
RefSeqi | XP_001349975.1, XM_001349939.1 |
Genome annotation databases
EnsemblProtistsi | CAD52383; CAD52383; PF3D7_1323500 |
GeneDBi | PF3D7_1323500.1:pep |
GeneIDi | 814104 |
KEGGi | pfa:PF3D7_1323500 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844509 Genomic DNA Translation: CAD52383.1 |
RefSeqi | XP_001349975.1, XM_001349939.1 |
3D structure databases
SMRi | Q8I6Z5 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q8I6Z5 |
ChEMBLi | CHEMBL3559649 |
Protein family/group databases
MEROPSi | A01.075 |
TCDBi | 8.A.32.1.6, the Beta-amyloid cleaving enzyme (bace1) family |
PTM databases
SwissPalmi | Q8I6Z5 |
Proteomic databases
PRIDEi | Q8I6Z5 |
Genome annotation databases
EnsemblProtistsi | CAD52383; CAD52383; PF3D7_1323500 |
GeneDBi | PF3D7_1323500.1:pep |
GeneIDi | 814104 |
KEGGi | pfa:PF3D7_1323500 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1323500 |
Phylogenomic databases
HOGENOMi | CLU_526282_0_0_1 |
InParanoidi | Q8I6Z5 |
OMAi | PFNLNNS |
Enzyme and pathway databases
Reactomei | R-PFA-2132295, MHC class II antigen presentation R-PFA-6798695, Neutrophil degranulation |
Miscellaneous databases
PHI-basei | PHI:8625 |
Family and domain databases
CDDi | cd06096, Plasmepsin_5, 1 hit |
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf IPR033866, Plasmepsin_5 IPR032861, TAXi_N |
PANTHERi | PTHR13683, PTHR13683, 1 hit |
Pfami | View protein in Pfam PF00026, Asp, 1 hit PF14543, TAXi_N, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS00141, ASP_PROTEASE, 1 hit PS51767, PEPTIDASE_A1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I6Z5_PLAF7 | |
Accessioni | Q8I6Z5Primary (citable) accession number: Q8I6Z5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | October 7, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |