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UniProtKB - Q8I6Z5 (Q8I6Z5_PLAF7)

Entry version 116 (10 Feb 2021)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Plasmepsin V

Gene

PF3D7_1323500

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-PFA-2132295, MHC class II antigen presentation
R-PFA-6798695, Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...MEROPSi		A01.075

Transport Classification Database

More...TCDBi		8.A.32.1.6, the Beta-amyloid cleaving enzyme (bace1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Plasmepsin VImported (EC:3.4.23.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1323500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		PlasmoDB:PF3D7_1323500

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 31HelicalSequence analysisAdd BLAST20
Transmembranei546 – 567HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:8625

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3559649

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q8I6Z5

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8I6Z5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8I6Z5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8I6Z5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 514Peptidase A1InterPro annotationAdd BLAST415

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni282 – 316DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili33 – 81Sequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A1 family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_526282_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8I6Z5

Identification of Orthologs from Complete Genome Data

More...OMAi		PFNLNNS

Family and domain databases

Conserved Domains Database

More...CDDi		cd06096, Plasmepsin_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.70.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001461, Aspartic_peptidase_A1
IPR001969, Aspartic_peptidase_AS
IPR033121, PEPTIDASE_A1
IPR021109, Peptidase_aspartic_dom_sf
IPR033866, Plasmepsin_5
IPR032861, TAXi_N

The PANTHER Classification System

More...PANTHERi		PTHR47966, PTHR47966, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00026, Asp, 1 hit
PF14543, TAXi_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00792, PEPSIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50630, SSF50630, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00141, ASP_PROTEASE, 1 hit
PS51767, PEPTIDASE_A1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I6Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNYFLRKEN FFILFCFVFV SIFFVSNVTI IKCNNVENKI DNVGKKIENV 
        60         70         80         90        100
GKKIGDMENK NDNVENKNDN VGNKNDNVKN ASSDLYKYKL YGDIDEYAYY 
       110        120        130        140        150
FLDIDIGKPS QRISLILDTG SSSLSFPCNG CKDCGIHMEK PYNLNYSKTS 
       160        170        180        190        200
SILYCNKSNC PYGLKCVGNK CEYLQSYCEG SQIYGFYFSD IVTLPSYNNK 
       210        220        230        240        250
NKISFEKLMG CHMHEESLFL HQQATGVLGF SLTKPNGVPT FVDLLFKHTP 
       260        270        280        290        300
SLKPIYSICV SEHGGELIIG GYEPDYFLSN QKEKQKMDKS DNNSSNKGNV 
       310        320        330        340        350
SIKLKNNDKN DDEENNSKDV IVSNNVEDIV WQAITRKYYY YIKIYGLDLY 
       360        370        380        390        400
GTNIMDKKEL DMLVDSGSTF THIPENIYNQ INYYLDILCI HDMTNIYEIN 
       410        420        430        440        450
KRLKLTNESL NKPLVYFEDF KTALKNIIQN ENLCIKIVDG VQCWKSLENL 
       460        470        480        490        500
PNLYITLSNN YKMIWKPSSY LYKKESFWCK GLEKQVNNKP ILGLTFFKNK 
       510        520        530        540        550
QVIFDLQQNQ IAFIESKCPS NLTSSRPRTF NEYREKENIF LKVSYINLYC 
       560        570        580        590
LWLLLALTIL LSLILYVRKM FYMDYFPLSD QNKSPIQEST
Length:590
Mass (Da):68,480
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0108FA9E9C38832
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52383.1

NCBI Reference Sequences

More...RefSeqi		XP_001349975.1, XM_001349939.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CAD52383; CAD52383; PF3D7_1323500

GeneDB pathogen genome database from Sanger Institute

More...GeneDBi		PF3D7_1323500.1:pep

Database of genes from NCBI RefSeq genomes

More...GeneIDi		814104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pfa:PF3D7_1323500

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52383.1
RefSeqiXP_001349975.1, XM_001349939.1

3D structure databases

SMRiQ8I6Z5
ModBaseiSearch...

Chemistry databases

BindingDBiQ8I6Z5
ChEMBLiCHEMBL3559649

Protein family/group databases

MEROPSiA01.075
TCDBi8.A.32.1.6, the Beta-amyloid cleaving enzyme (bace1) family

PTM databases

SwissPalmiQ8I6Z5

Proteomic databases

PRIDEiQ8I6Z5

Genome annotation databases

EnsemblProtistsiCAD52383; CAD52383; PF3D7_1323500
GeneDBiPF3D7_1323500.1:pep
GeneIDi814104
KEGGipfa:PF3D7_1323500

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1323500

Phylogenomic databases

HOGENOMiCLU_526282_0_0_1
InParanoidiQ8I6Z5
OMAiPFNLNNS

Enzyme and pathway databases

ReactomeiR-PFA-2132295, MHC class II antigen presentation
R-PFA-6798695, Neutrophil degranulation

Miscellaneous databases

PHI-baseiPHI:8625

Family and domain databases

CDDicd06096, Plasmepsin_5, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001461, Aspartic_peptidase_A1
IPR001969, Aspartic_peptidase_AS
IPR033121, PEPTIDASE_A1
IPR021109, Peptidase_aspartic_dom_sf
IPR033866, Plasmepsin_5
IPR032861, TAXi_N
PANTHERiPTHR47966, PTHR47966, 2 hits
PfamiView protein in Pfam
PF00026, Asp, 1 hit
PF14543, TAXi_N, 1 hit
PRINTSiPR00792, PEPSIN
SUPFAMiSSF50630, SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141, ASP_PROTEASE, 1 hit
PS51767, PEPTIDASE_A1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I6Z5_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I6Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 10, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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