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Entry version 66 (17 Jun 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Glycophorin-binding protein

Gene

GBP

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in erythrocyte invasion.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycophorin-binding protein
Alternative name(s):
GBP-130
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GBP
ORF Names:PF10_0159
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1016300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Note: Erythrocyte cytoplasm of schizonts. Released into the culture supernatant at the time of schizont rupture. Only a minor fraction of GBP was found to be loosely associated with merozoites (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Malaria

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638, Artenimol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002171851 – 824Glycophorin-binding proteinAdd BLAST824

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I6U8

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I6U8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Merozoite

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host glycophorin.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I6U8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati226 – 275GBP 1Add BLAST50
Repeati276 – 325GBP 2Add BLAST50
Repeati326 – 375GBP 3Add BLAST50
Repeati376 – 424GBP 4Add BLAST49
Repeati425 – 474GBP 5Add BLAST50
Repeati475 – 524GBP 6Add BLAST50
Repeati525 – 574GBP 7Add BLAST50
Repeati575 – 624GBP 8Add BLAST50
Repeati625 – 674GBP 9Add BLAST50
Repeati675 – 724GBP 10Add BLAST50
Repeati725 – 774GBP 11Add BLAST50
Repeati775 – 824GBP 12Add BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 204Lys-richAdd BLAST109

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_343722_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I6U8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESTPNDN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8I6U8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003681, Glycophorin-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02526, GBP_repeat, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51069, GBP, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8I6U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSKVSDIK STGVSNYKNF NSKNSSKYSL MEVSKKNEKK NSLGAFHSKK
60 70 80 90 100
ILLIFGIIYV VLLNAYICGD KYEKAVDYGF RESRILAEGE DTCARKEKTT
110 120 130 140 150
LRKSKQKTST RTVATQTKKD EENKSVVTEE QKVESDSEKQ KRTKKVVKKQ
160 170 180 190 200
INIGDTENQK EGKNVKKVIK KEKKKEESGK PEENKHANEA SKKQEPKASK
210 220 230 240 250
VSQKPSTSTR SNNEVKIRAA SNQETLTSAD PEGQIMREYA ADPEYRKHLE
260 270 280 290 300
IFYKILTNTD PNDEVERRNA DNKEDLTSAD PEGQIMREYA SDPEYRKHLE
310 320 330 340 350
IFYKILTNTD PNDDVERRNA DNKEDLTSAD PEGQIMREYA ADPEYRKHLE
360 370 380 390 400
VFHKILTNTD PNDEVERRNA DNKEDLTSAD PEGQIMREYA ADPEYRKHLE
410 420 430 440 450
VFHKILTNTD PNDEVERRNA DNKELTSSDP EGQIMREYAA DPEYRKHLEV
460 470 480 490 500
FHKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEV
510 520 530 540 550
FHKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEI
560 570 580 590 600
FHKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEI
610 620 630 640 650
FYKILTNTDP NDEVERRNAD NKEELTSSDP EGQIMREYAA DPEYRKHLEI
660 670 680 690 700
FHKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEI
710 720 730 740 750
FYKILTNTDP NDEVERRNAD NKEDLTSADP EGQIMREYAS DPEYRKHLEI
760 770 780 790 800
FYKILTNTDP NDDVERRNAD NKEDLTSADP EGQIMREYAA DPEYRKHLEV
810 820
FHKILTNTDP NDEVERQNAD NNEA
Length:824
Mass (Da):95,844
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A8FBE83C94B8D33
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A143ZWU2A0A143ZWU2_PLAF7
GBP130 protein
PF3D7_1016300
824Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014185 Genomic DNA Translation: AAN35357.1

NCBI Reference Sequences

More...
RefSeqi
XP_001347444.1, XM_001347408.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98416; CZT98416; PF3D7_1016300

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1016300.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
810317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1016300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014185 Genomic DNA Translation: AAN35357.1
RefSeqiXP_001347444.1, XM_001347408.1

3D structure databases

SMRiQ8I6U8
ModBaseiSearch...

Chemistry databases

DrugBankiDB11638, Artenimol

PTM databases

SwissPalmiQ8I6U8

Proteomic databases

PRIDEiQ8I6U8

Genome annotation databases

EnsemblProtistsiCZT98416; CZT98416; PF3D7_1016300
GeneDBiPF3D7_1016300.1:pep
GeneIDi810317
KEGGipfa:PF3D7_1016300

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1016300

Phylogenomic databases

HOGENOMiCLU_343722_0_0_1
InParanoidiQ8I6U8
OMAiESTPNDN
PhylomeDBiQ8I6U8

Family and domain databases

InterProiView protein in InterPro
IPR003681, Glycophorin-bd
PfamiView protein in Pfam
PF02526, GBP_repeat, 12 hits
PROSITEiView protein in PROSITE
PS51069, GBP, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBP_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I6U8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: June 17, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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