We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8I603 (Q8I603_PLAF7)
Protein
Eukaryotic translation initiation factor 5A
Gene
PF3D7_1204300
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
GO - Molecular functioni
- ribosome binding Source: UniProtKB-UniRule
- translation elongation factor activity Source: GO_Central
- translation initiation factor activity Source: GeneDB
GO - Biological processi
- positive regulation of translational elongation Source: GO_Central
- positive regulation of translational termination Source: UniProtKB-UniRule
- translational initiation Source: GeneDB
Keywordsi
Molecular function | Initiation factorImported, Ribonucleoprotein, Ribosomal proteinARBA annotation |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
Reactomei | R-PFA-204626, Hypusine synthesis from eIF5A-lysine |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 5AUniRule annotationShort name: eIF-5AUniRule annotation |
Gene namesi | ORF Names:PF3D7_1204300Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1204300 |
PTM / Processingi
Post-translational modificationi
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).UniRule annotation
Keywords - PTMi
HypusineUniRule annotationARBA annotationProteomic databases
PRIDEi | Q8I603 |
PTM databases
SwissPalmi | Q8I603 |
Interactioni
Protein-protein interaction databases
IntActi | Q8I603, 2 interactors |
STRINGi | 5833.PFL0210c |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 157 | eIF-5aInterPro annotationAdd BLAST | 75 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_102600_0_0_1 |
OMAi | MAEEEHT |
PhylomeDBi | Q8I603 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR001884, IF5A-like IPR012340, NA-bd_OB-fold IPR014722, Rib_L2_dom2 IPR019769, Trans_elong_IF5A_hypusine_site IPR020189, Transl_elong_IF5A_C IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR11673, PTHR11673, 1 hit |
Pfami | View protein in Pfam PF01287, eIF-5a, 1 hit |
PIRSFi | PIRSF003025, eIF5A, 1 hit |
SMARTi | View protein in SMART SM01376, eIF-5a, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00037, eIF_5A, 1 hit |
PROSITEi | View protein in PROSITE PS00302, IF5A_HYPUSINE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I603-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDHEMYDNI DAGASQTYPV QAGAIKKNGH VMLKEHPCKV VDYSTSKTGK
60 70 80 90 100
HGHAKAHIVG IDIFTGRKYE DICPTSHNMD VPVVKRTELQ LIDITEDGFV
110 120 130 140 150
SLLYDNGDTK DDLSLPKDTE GNLDEVAKQI RNLFDNGKSV LVSVLSACGQ
160
EKIIAAKELS S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99206.1 |
RefSeqi | XP_001350451.1, XM_001350415.1 |
Genome annotation databases
EnsemblProtistsi | CZT99206; CZT99206; PF3D7_1204300 |
GeneIDi | 811095 |
KEGGi | pfa:PF3D7_1204300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99206.1 |
RefSeqi | XP_001350451.1, XM_001350415.1 |
3D structure databases
SMRi | Q8I603 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8I603, 2 interactors |
STRINGi | 5833.PFL0210c |
PTM databases
SwissPalmi | Q8I603 |
Proteomic databases
PRIDEi | Q8I603 |
Genome annotation databases
EnsemblProtistsi | CZT99206; CZT99206; PF3D7_1204300 |
GeneIDi | 811095 |
KEGGi | pfa:PF3D7_1204300 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1204300 |
Phylogenomic databases
HOGENOMi | CLU_102600_0_0_1 |
OMAi | MAEEEHT |
PhylomeDBi | Q8I603 |
Enzyme and pathway databases
Reactomei | R-PFA-204626, Hypusine synthesis from eIF5A-lysine |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR001884, IF5A-like IPR012340, NA-bd_OB-fold IPR014722, Rib_L2_dom2 IPR019769, Trans_elong_IF5A_hypusine_site IPR020189, Transl_elong_IF5A_C IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR11673, PTHR11673, 1 hit |
Pfami | View protein in Pfam PF01287, eIF-5a, 1 hit |
PIRSFi | PIRSF003025, eIF5A, 1 hit |
SMARTi | View protein in SMART SM01376, eIF-5a, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00037, eIF_5A, 1 hit |
PROSITEi | View protein in PROSITE PS00302, IF5A_HYPUSINE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I603_PLAF7 | |
Accessioni | Q8I603Primary (citable) accession number: Q8I603 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |