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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC3

Gene

PF3D7_1213700

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.UniRule annotation

GO - Molecular functioni

  • DNA-directed 5'-3' RNA polymerase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseImported, Transferase
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-PFA-113418 Formation of the Early Elongation Complex
R-PFA-6781823 Formation of TC-NER Pre-Incision Complex

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC3UniRule annotation
Gene namesi
ORF Names:PF3D7_1213700Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1213700

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymeraseImported, NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8I5R8

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic RPB8 RNA polymerase subunit family.UniRule annotation

Phylogenomic databases

KOiK03016
OMAiIMSGRIF

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR005570 RNA_pol_Rpb8
PANTHERiPTHR10917 PTHR10917, 1 hit
PfamiView protein in Pfam
PF03870 RNA_pol_Rpb8, 1 hit
PIRSFiPIRSF000779 RNA_pol_Rpb8, 1 hit
SMARTiView protein in SMART
SM00658 RPOL8c, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequencei

Sequence statusi: Complete.

Q8I5R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNILFEDR FVISSVDNSK FEKVSRIKAK STGYDAELIL DVHSELFKVE
60 70 80 90 100
EKKAIYLALQ DKLLNRNDEK GWEQNENVPL NNIEYIMSGR IFKFEELSSE
110 120 130 140
RRTVYASFGG LMMALTTDKQ FIGDLEIDMK IYLLTKNIDI ERTRE
Length:145
Mass (Da):16,898
Last modified:March 1, 2003 - v1
Checksum:iFD2A1976BC1F6C3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99298.1
RefSeqiXP_001350542.1, XM_001350506.1

Genome annotation databases

EnsemblProtistsiCZT99298; CZT99298; PF3D7_1213700
GeneDBiPF3D7_1213700.1:pep
GeneIDi811186
KEGGipfa:PF3D7_1213700

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99298.1
RefSeqiXP_001350542.1, XM_001350506.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8I5R8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZT99298; CZT99298; PF3D7_1213700
GeneDBiPF3D7_1213700.1:pep
GeneIDi811186
KEGGipfa:PF3D7_1213700

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1213700

Phylogenomic databases

KOiK03016
OMAiIMSGRIF

Enzyme and pathway databases

ReactomeiR-PFA-113418 Formation of the Early Elongation Complex
R-PFA-6781823 Formation of TC-NER Pre-Incision Complex

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR005570 RNA_pol_Rpb8
PANTHERiPTHR10917 PTHR10917, 1 hit
PfamiView protein in Pfam
PF03870 RNA_pol_Rpb8, 1 hit
PIRSFiPIRSF000779 RNA_pol_Rpb8, 1 hit
SMARTiView protein in SMART
SM00658 RPOL8c, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8I5R8_PLAF7
AccessioniPrimary (citable) accession number: Q8I5R8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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