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Entry version 137 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Polyadenylate-binding protein

Gene

PF3D7_1224300

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds the poly(A) tail of mRNA.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-PFA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-PFA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyadenylate-binding proteinUniRule annotation
Short name:
PABPUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1224300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_1224300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638, Artenimol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I5H4

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I5H4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I5H4, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I5H4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 94RRMInterPro annotationAdd BLAST79
Domaini104 – 176RRMInterPro annotationAdd BLAST73
Domaini193 – 261RRMInterPro annotationAdd BLAST69
Domaini450 – 527RRMInterPro annotationAdd BLAST78
Domaini799 – 875PABCInterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni268 – 414DisorderedSequence analysisAdd BLAST147
Regioni692 – 759DisorderedSequence analysisAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili854 – 874Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi289 – 307Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi308 – 402Polar residuesSequence analysisAdd BLAST95

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polyadenylate-binding protein type-1 family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012062_22_3_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYMQPPV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8I5H4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR036053, PABP-dom
IPR006515, PABP_1234
IPR002004, PABP_HYD
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00658, PABP, 1 hit
PF00076, RRM_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00517, PolyA, 1 hit
SM00360, RRM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 3 hits
SSF63570, SSF63570, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01628, PABP-1234, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51309, PABC, 1 hit
PS50102, RRM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I5H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIATGTNMMH PSFSTASLYV GDLNEDVTEA VLYEIFNTVG HVSSIRVCRD
60 70 80 90 100
SVTRKSLGYA YVNYHNLADA ERALDTLNYT NIKGQPARLM WSHRDPSLRK
110 120 130 140 150
SGTGNIFVKN LDKSIDNKAL FDTFSMFGNI LSCKVATDEF GKSKSYGFVH
160 170 180 190 200
YEDEESAKEA IEKVNGVQLG SKNVYVGPFI KKSERATNDT KFTNLYVKNF
210 220 230 240 250
PDSVTETHLR QLFNPYGEIT SMIVKMDNKN RKFCFINYAD AESAKNAMDN
260 270 280 290 300
LNGKKITDDG QIDETYDPKK EEATASTSGA ANQTTGTDAD KTDKNDKNNK
310 320 330 340 350
ADKNEKGDSS NANNNATATG ATTTDTTTTP GETTTTTANA DSTGANNNNG
360 370 380 390 400
LSPNTNTSNT TTGSSNNSIN LNENNNTAGN NNSTNNNNNS GSSMNNAGSA
410 420 430 440 450
KKDETAASDC ADTPNILYVG PHQSRARRHA ILKAKFDNLN VENKNKHQGV
460 470 480 490 500
NLYIKNLDDG IDDIMLRELF EPFGTITSAK VMRDEKEQSK GFGFVCFASQ
510 520 530 540 550
EEANKAVTEM HLKIINGKPL YVGLAEKREQ RLSRLQQRFR MHPIRHHMNN
560 570 580 590 600
PLNTPMQYAS PQSPQLQFSQ NTLSYGRPVI TAFNQNNLIS WRHQQAAQQQ
610 620 630 640 650
AVHQQAVHQQ AAQQQLNFNT NLRGQINQMR LYTQNNMMNN NLNQNKPNAQ
660 670 680 690 700
LHHNQQYVPN ALAQNGQQQP NLNAAGQHNA QQLQQQGNNQ LLNNNMRNMN
710 720 730 740 750
NRANRNMGNL GNMNNQKQLP LNINNKQQNA ASQANQMNHQ AQPQGAQAQQ
760 770 780 790 800
KNPQQMQQVP QGNNFKFTAQ ARNRMELPNK NANKVNTMNN NMNVNFNNNS
810 820 830 840 850
TLTAAALASA PPSMQKQVLG ENLFPLVANY HPTLAGKITG MMLEMDNSEL
860 870
LILLENEEQL KKKIDEALVV LQKAK
Length:875
Mass (Da):97,230
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B47DF1BFB36A194
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99402.1

NCBI Reference Sequences

More...
RefSeqi
XP_001350640.1, XM_001350604.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT99402; CZT99402; PF3D7_1224300

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1224300.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
811286

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1224300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99402.1
RefSeqiXP_001350640.1, XM_001350604.1

3D structure databases

SMRiQ8I5H4
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I5H4, 1 interactor

Chemistry databases

DrugBankiDB11638, Artenimol

PTM databases

SwissPalmiQ8I5H4

Proteomic databases

PRIDEiQ8I5H4

Genome annotation databases

EnsemblProtistsiCZT99402; CZT99402; PF3D7_1224300
GeneDBiPF3D7_1224300.1:pep
GeneIDi811286
KEGGipfa:PF3D7_1224300

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1224300

Phylogenomic databases

HOGENOMiCLU_012062_22_3_1
OMAiQYMQPPV
PhylomeDBiQ8I5H4

Enzyme and pathway databases

ReactomeiR-PFA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-PFA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-PFA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR036053, PABP-dom
IPR006515, PABP_1234
IPR002004, PABP_HYD
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00658, PABP, 1 hit
PF00076, RRM_1, 4 hits
SMARTiView protein in SMART
SM00517, PolyA, 1 hit
SM00360, RRM, 4 hits
SUPFAMiSSF54928, SSF54928, 3 hits
SSF63570, SSF63570, 1 hit
TIGRFAMsiTIGR01628, PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309, PABC, 1 hit
PS50102, RRM, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I5H4_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I5H4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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