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Entry version 131 (05 Jun 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Ubiquitin-activating enzyme E1

Gene

PF3D7_1225800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-PFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.16.1.3 the endoplasmic reticular retrotranslocon (er-rt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin-activating enzyme E1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1225800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1225800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I5F9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8I5F9, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8I5F9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K03178

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIVWARL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.2660, 1 hit
3.10.290.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR042063 Ubi_acti_E1_SCCH
IPR035985 Ubiquitin-activating_enz
IPR033127 UBQ-activ_enz_E1_Cys_AS
IPR000011 UBQ/SUMO-activ_enz_E1-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01849 UBIQUITINACT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00985 UBA_e1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69572 SSF69572, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I5F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNKTPPLKK QRTDESVKPI EFDKSSESWK RSDCLEKMTE NKIDTDLYSR
60 70 80 90 100
QLGTYGFDLM NKLVKLNILI INVKGVGLEC AKNLILSGPQ SVCIYDNDIC
110 120 130 140 150
DISDIGVNFY INEKDVEDKS CRSDAVLKEL QELNNYVHIY NYKGTIEKNW
160 170 180 190 200
LENFDVVICC DINKEDLIKY NNMIRGIDKK RIAFLSCNIY GLCGYIFVDF
210 220 230 240 250
NKEFICYDSN GEQVKSCNVS KISKELEGKV SFDFDKTSPF EEGDYVQFSN
260 270 280 290 300
VEGMTEINNK IYKIKNLKKY TFEIGDTSLY SEYIKGGICT QVKKHLKLNF
310 320 330 340 350
YPYEYICVNP LNNENISNNE QKHNQNDNHF LDTCNNIIYE NIPQPNSFII
360 370 380 390 400
SDYAKFDMSN HLHYSIQALK WYELQNEKGL PENSDEDALE KIYNYAVTLN
410 420 430 440 450
NKDKEEKKSY AVEQLKKDVV YNVCRYSKSH IAPVASFFGG LLAQEVIKFT
460 470 480 490 500
GKYMPIYQLL YLDFFECISL NEKVDINEIK KMNCKNDNII TVFGKSFQKK
510 520 530 540 550
LNNLNVFLVG SGALGCEYAK LFSLLDMCTR NSEQNTNLNQ NNIDNNLACC
560 570 580 590 600
GKLTITDNDN IEVSNLNRQF LFRREHVGKS KSLVSSEIIK KKNNNMHVQS
610 620 630 640 650
LETKVGAENE HIFNEEFWTK QNIIVNALDN IQARQYVDNK CVWYSKPLFE
660 670 680 690 700
SGTLGTKGNV QVIIPYLTQS YNDSYDPPED SIPLCTLKHF PYDIVHTIEY
710 720 730 740 750
ARDIFQGLFY NTPLSIKQFL NDKEEYINKI QEEGNNASLL ENLQNVINSL
760 770 780 790 800
KEISSQCNFD FCIKKSVELF HNNFINQINQ LLYSFPLDYK LSSGEYFWVG
810 820 830 840 850
QKKPPQPIVF DVNNEMIQEF LLSTSNLLAQ VYNIPPCFDI NYIINVAKKI
860 870 880 890 900
EVKPFEPKKV KINMDEKNLN NISISFAEEE KIIDDFCKEL LNIPTNNIKI
910 920 930 940 950
NPIEFDKDEQ TNLHVNFIYA FSNLRAINYK INTCDKLKAK IVAGKIIPAL
960 970 980 990 1000
ATTTSIITGL VGIELLKYVN YYDNIQAYVK LSDEQRKKEK HDVLSYFKNA
1010 1020 1030 1040 1050
FINSALPLFL FSEPMPPLRM MDKEYDELMK GPVKAIPNGF SSWDKIVISI
1060 1070 1080 1090 1100
KNGTIKDLID HINEKYSIDV NLISVGNACL YNCYLPAHNK ERLNKPIHEL
1110 1120 1130 1140
YKQISKQDLL EDKNYIIVEA SCSDQDLVDV LIPSIQFIYK
Length:1,140
Mass (Da):131,778
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB57B45443196D52F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99417.1

NCBI Reference Sequences

More...
RefSeqi
XP_001350655.1, XM_001350619.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT99417; CZT99417; PF3D7_1225800

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1225800.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
811301

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1225800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99417.1
RefSeqiXP_001350655.1, XM_001350619.1

3D structure databases

SMRiQ8I5F9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I5F9, 2 interactors

Protein family/group databases

TCDBi3.A.16.1.3 the endoplasmic reticular retrotranslocon (er-rt) family

Proteomic databases

PRIDEiQ8I5F9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZT99417; CZT99417; PF3D7_1225800
GeneDBiPF3D7_1225800.1:pep
GeneIDi811301
KEGGipfa:PF3D7_1225800

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1225800

Phylogenomic databases

KOiK03178
OMAiCIVWARL

Enzyme and pathway databases

ReactomeiR-PFA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-PFA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Family and domain databases

Gene3Di1.10.10.2660, 1 hit
3.10.290.60, 1 hit
InterProiView protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR042063 Ubi_acti_E1_SCCH
IPR035985 Ubiquitin-activating_enz
IPR033127 UBQ-activ_enz_E1_Cys_AS
IPR000011 UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit
PRINTSiPR01849 UBIQUITINACT
SMARTiView protein in SMART
SM00985 UBA_e1_C, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
PROSITEiView protein in PROSITE
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I5F9_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I5F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 5, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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