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UniProtKB - Q8I592 (Q8I592_PLAF7)
Protein
Elongation factor G, mitochondrial
Gene
PF3D7_1233000
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
UniRule annotation: polypeptide chain elongation Pathwayi
This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 51 – 58 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 122 – 126 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 176 – 179 | GTPUniRule annotation | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GeneDB
- translation elongation factor activity Source: GeneDB
GO - Biological processi
- mitochondrial translational elongation Source: GO_Central
- translational elongation Source: GeneDB
Keywordsi
Molecular function | Elongation factorUniRule annotationARBA annotation |
Biological process | Protein biosynthesis |
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00345 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor G, mitochondrialUniRule annotationShort name: EF-GmtUniRule annotation Alternative name(s): Elongation factor G 1, mitochondrialUniRule annotation Short name: mEF-G 1UniRule annotation Elongation factor G1UniRule annotation |
Gene namesi | ORF Names:PF3D7_1233000Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1233000 |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotationARBA annotation
Mitochondrion
- mitochondrion Source: GeneDB
Keywords - Cellular componenti
MitochondrionUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 333 | Tr-type GInterPro annotationAdd BLAST | 292 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_002794_4_1_1 |
OMAi | AATTCHW |
PhylomeDBi | Q8I592 |
Family and domain databases
CDDi | cd16262, EFG_III, 1 hit cd01434, EFG_mtEFG1_IV, 1 hit cd03713, EFG_mtEFG_C, 1 hit |
Gene3Di | 3.30.230.10, 1 hit 3.40.50.300, 1 hit |
HAMAPi | MF_00054_B, EF_G_EF_2_B, 1 hit |
InterProi | View protein in InterPro IPR045044, EFG1-like IPR041095, EFG_II IPR009022, EFG_III IPR035647, EFG_III/V IPR035649, EFG_V IPR000640, EFG_V-like IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR005225, Small_GTP-bd_dom IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR004540, Transl_elong_EFG/EF2 IPR005517, Transl_elong_EFG/EF2_IV |
PANTHERi | PTHR43636, PTHR43636, 1 hit |
Pfami | View protein in Pfam PF00679, EFG_C, 1 hit PF14492, EFG_III, 1 hit PF03764, EFG_IV, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SMARTi | View protein in SMART SM00838, EFG_C, 1 hit SM00889, EFG_IV, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF54980, SSF54980, 2 hits |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I592-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIILKHILYK NNGRRFFEKT IPNKIYNFYL SGLCKFSSCC IDNLRNIGIS
60 70 80 90 100
AHIDAGKTTL TERILYYTGK IKSIHEVRGN DGVGATMDSM ELEREKGITI
110 120 130 140 150
QSATTNCVWE INNKKYNINI IDTPGHVDFT IEVERSLRVL DSAILVICGV
160 170 180 190 200
SGVQSQTLTV NRQMDRYHIP RILFINKLDR DGANVERTLH TIEKRLNLNT
210 220 230 240 250
ILLQMPIGIE QKFKGVYDLI NRKGYLFQGK NGIILNEINN KEEILSLDNS
260 270 280 290 300
FSFEIMELLR NRILEKLADV DDEFAEIYLN NDINDIKKND IYSSIRKSTI
310 320 330 340 350
KNLVTPICLG SAKNNVGVQI LLNYVCNFLP SPKEINNYGY IIYSDVLEDK
360 370 380 390 400
IKNNDICNET QNTQQYQSQD QNDISIINYN NQNSINNYTH KDDHHSSKNK
410 420 430 440 450
SKKKIQLLCD NNLPMVGFLF KIQEDNMYGQ MSYFRIYQGK IKKKEMITNM
460 470 480 490 500
MTNKKEIVKK IMKMHSNMAK EVNEASAGDI VAICGINGST GTTYTNGINT
510 520 530 540 550
NLHLLNIFIP KPVISVAVEI LKKGDMTKLT KALNKFTKED PTFYVKTDEQ
560 570 580 590 600
TKETIFEGIG ELQLEIYKER LKREFNINVN LKNPKINFKE TITKPFECSY
610 620 630 640 650
TYKKQKGGAG LYAHVHAIFE TISDNYNDTT HCTFVNEVIG NDLPKNFILS
660 670 680 690 700
IEKAFKEQIE KGYLYNSEII NMKMRLIGGK IHEVDSNDLA FKKATINLIK
710 720 730 740 750
ENYHNFCPVL LEPIMLVEII SNYEHQSNIL TSITKRKGLV NNIVNNLNII
760 770 780 790 800
YIYADIPLKH MFNYINEIRA ITQGQGTYTM EFSRYEQVSK NDLDEILKQK
STA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99489.1 |
RefSeqi | XP_001350724.1, XM_001350688.1 |
Genome annotation databases
EnsemblProtistsi | CZT99489; CZT99489; PF3D7_1233000 |
GeneIDi | 811370 |
KEGGi | pfa:PF3D7_1233000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99489.1 |
RefSeqi | XP_001350724.1, XM_001350688.1 |
3D structure databases
SMRi | Q8I592 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8I592, 1 interactor |
STRINGi | 5833.PFL1590c |
Genome annotation databases
EnsemblProtistsi | CZT99489; CZT99489; PF3D7_1233000 |
GeneIDi | 811370 |
KEGGi | pfa:PF3D7_1233000 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1233000 |
Phylogenomic databases
HOGENOMi | CLU_002794_4_1_1 |
OMAi | AATTCHW |
PhylomeDBi | Q8I592 |
Enzyme and pathway databases
UniPathwayi | UPA00345 |
Family and domain databases
CDDi | cd16262, EFG_III, 1 hit cd01434, EFG_mtEFG1_IV, 1 hit cd03713, EFG_mtEFG_C, 1 hit |
Gene3Di | 3.30.230.10, 1 hit 3.40.50.300, 1 hit |
HAMAPi | MF_00054_B, EF_G_EF_2_B, 1 hit |
InterProi | View protein in InterPro IPR045044, EFG1-like IPR041095, EFG_II IPR009022, EFG_III IPR035647, EFG_III/V IPR035649, EFG_V IPR000640, EFG_V-like IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR005225, Small_GTP-bd_dom IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR004540, Transl_elong_EFG/EF2 IPR005517, Transl_elong_EFG/EF2_IV |
PANTHERi | PTHR43636, PTHR43636, 1 hit |
Pfami | View protein in Pfam PF00679, EFG_C, 1 hit PF14492, EFG_III, 1 hit PF03764, EFG_IV, 1 hit PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SMARTi | View protein in SMART SM00838, EFG_C, 1 hit SM00889, EFG_IV, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF54980, SSF54980, 2 hits |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I592_PLAF7 | |
Accessioni | Q8I592Primary (citable) accession number: Q8I592 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |