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Entry version 106 (22 Apr 2020)
Sequence version 2 (22 Sep 2009)
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Protein
Submitted name:

V-type K+-independent H+-translocating inorganic pyrophosphatase

Gene

PF3D7_1235200

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
V-type K+-independent H+-translocating inorganic pyrophosphataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1235200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1235200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I570

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni313 – 333DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008743_3_1_1

KEGG Orthology (KO)

More...
KOi
K23025

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWKGILF

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01129 PPase_energized_pump, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004131 PPase-energised_H-pump

The PANTHER Classification System

More...
PANTHERi
PTHR31998 PTHR31998, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03030 H_PPase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMLPLHENS STIRKKYKKN NKFFGGETSV KNFLERYSFT NKKDNKKNEK
60 70 80 90 100
GTKLNILKYM KLYMQKPVKH RITFNIIVFT LFLVIIYIFY HKIENIKTVF
110 120 130 140 150
LISLTLYSLY FLLFSLYMLS TILNDEYGDY NTLKKYDMTN NIYMNDNELN
160 170 180 190 200
LINDKNDVQQ INNSQNNNDN YVHQMTNDHN IQKKEIKKEY EKLKYDNHNN
210 220 230 240 250
NENNLINPYN LEQNNQTFNQ HISNEYEKNN INLIHTKNTN NDNKGDMKNE
260 270 280 290 300
IGTNEGYEIS SFDSIGIPIK EGSEGFFTVQ YNSIFKISIV FTLLILSLYI
310 320 330 340 350
IRGEDTKLPQ GDNQMTDMMN NNNNNNNNNN NNSSSSNGTI IISSYAYGII
360 370 380 390 400
TAISFLLGAL CSSIAGYNGI YVAVRANVKV AKAATYSYKK ALITCFRSGA
410 420 430 440 450
VSAIVNVALA IFGICSLLLL VNILYPTLAF SKYPLLIVGY GFGASLVAML
460 470 480 490 500
YQLAGGIYTK AADIGADLVG KVEKHIPEDD PRNPAVIADL VGDNVGDCAG
510 520 530 540 550
QCADLFESIC AEIIASMILG GNLSENGIIS EQTASYFVLF PLFVHSMDLL
560 570 580 590 600
ISTIGIYLVS VKNNNEPFST LNLECNTKII DKKDINYFNN INSNMHVEES
610 620 630 640 650
AMQPLNNNNK EESDLLYAKY DCDVTSEQLE NPLKAMLKAY FFTCSLGVVG
660 670 680 690 700
FSFLCKLLFS LDNAKNAWIY FSFCGFIGMA CSYLFVILTR YYTDYSYPKV
710 720 730 740 750
KKIAHASLSG SATNIIAGLY VGLESTFFPV IVISISLLLS YYLGLKSNIT
760 770 780 790 800
GDHNIINGLY GTSVATMGML STAVFILSMS NFGPIADNAG GIVEMCKQPK
810 820 830 840 850
YVRVITDKLD AVGNVTKANT KGFSVGSAAL ACFLLFSAFL SEVSVHSKMP
860 870 880 890 900
FSTVDIAIPE VFIGGILGSV VVFLFAGWSL DAVGKTAEEV LKEVRRQFNE
910 920 930 940 950
HPGILTYKEK PDYHTCVAII SKRALIETIK PGLLGVLSPI IVGLIFKQLG
960 970 980 990 1000
ILQNNQLLGA QAMASFIMFS TSTGILMALF LNNAGGAWDN AKKYIESGYY
1010 1020 1030 1040 1050
GGKNSQAHVS SVIGDTVGDP CKDTAGPSIH VLIKLISTIT MVITPLIAST

TTKSVYS
Length:1,057
Mass (Da):117,106
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA8B4E11D37FFD59
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99511.1

NCBI Reference Sequences

More...
RefSeqi
XP_001350746.2, XM_001350710.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT99511; CZT99511; PF3D7_1235200

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1235200.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
811392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1235200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99511.1
RefSeqiXP_001350746.2, XM_001350710.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiQ8I570

Genome annotation databases

EnsemblProtistsiCZT99511; CZT99511; PF3D7_1235200
GeneDBiPF3D7_1235200.1:pep
GeneIDi811392
KEGGipfa:PF3D7_1235200

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1235200

Phylogenomic databases

HOGENOMiCLU_008743_3_1_1
KOiK23025
OMAiGWKGILF

Family and domain databases

HAMAPiMF_01129 PPase_energized_pump, 1 hit
InterProiView protein in InterPro
IPR004131 PPase-energised_H-pump
PANTHERiPTHR31998 PTHR31998, 1 hit
PfamiView protein in Pfam
PF03030 H_PPase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I570_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I570
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: September 22, 2009
Last modified: April 22, 2020
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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