UniProtKB - Q8I526 (Q8I526_PLAF7)
Protein
Submitted name:
ATP-dependent zinc metalloprotease FTSH 1
Gene
PF3D7_1239700
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- ATP binding Source: GeneDB
- ATP-dependent peptidase activity Source: GeneDB
- metalloendopeptidase activity Source: GeneDB
GO - Biological processi
- proteolysis Source: GeneDB
Keywordsi
Molecular function | Hydrolase, MetalloproteaseImportedARBA annotation, Protease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1239700Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1239700 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 93 | HelicalSequence analysisAdd BLAST | 28 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- mitochondrion Source: GeneDB
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 181 – 322 | AAAInterPro annotationAdd BLAST | 142 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 105 – 140 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 604 – 632 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 757 – 804 | DisorderedSequence analysisAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 27 – 47 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 646 – 666 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 720 – 740 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 617 – 632 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 757 – 773 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 774 – 804 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
In the C-terminal section; belongs to the peptidase M41 family.ARBA annotation
In the N-terminal section; belongs to the AAA ATPase family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_000688_11_0_1 |
OMAi | NKKWNYF |
Family and domain databases
Gene3Di | 1.20.58.760, 1 hit |
HAMAPi | MF_01458, FtsH, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR005936, FtsH IPR027417, P-loop_NTPase IPR000642, Peptidase_M41 IPR037219, Peptidase_M41-like |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF01434, Peptidase_M41, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF140990, SSF140990, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01241, FtsH_fam, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I526-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSKYDNQSF LSTGSDKYGE QENSVLLHDE EDEYINENKK KRNERDKKFR
60 70 80 90 100
YYENFFNRRR SKKWNYFIIF FLGVCLGFAI WPFFMTIITY RLFYKDNFNN
110 120 130 140 150
TNYRTNNSST SLKSYGNEKN KKSDNNGKVP MKDQSPNKVS PHFKPIRFEE
160 170 180 190 200
IAGIDESKLE LLEVVDFIKN REKYHEMGAR MPKGVLLVGP PGSGKTMLAR
210 220 230 240 250
AVATEANVPY IYTSGPEFIE IYVGQGAKRI RQLFAHARSV APSIVFIDEI
260 270 280 290 300
DAIGGKRSSG SVNGAGQREH DQTLNQLLVE MDGFSNTVHI MVIGATNRID
310 320 330 340 350
TLDSALLRPG RFDRIVYVPL PDINGRKKIL EIYIKKIKSD LKLEDIEKIA
360 370 380 390 400
RLTPGFSGAD LENVVNEATI LATRNNKSLV TINELYEARD KVSMGPERKS
410 420 430 440 450
LRQSDHQRRI TAYHEAGHAI VAYFLQPKTD PIHKATIISR GNALGYVEQI
460 470 480 490 500
PVDDRHNYFK SQMEAKLAVC MGGRTAEEIV FGKSETSSGA SSDISRATEI
510 520 530 540 550
AYKMVTEWGM SDKLGPLNYK KRMGDGYSSN RLSAQTVSSI EVEVKSLVEK
560 570 580 590 600
GKSLSEEILR RHRKELDNLA FALLDKETLS GEEIKNIIDP NNSKNYSGKV
610 620 630 640 650
EMLKNDTKKN EKKSNSVSKN KSTISEDYDK NQNNVEQNYQ SHDHTLVKNE
660 670 680 690 700
ENLNNMKNDI DDNNTRDGQV NSDSFVKRKE VTDQDINGKE LSEMDNKEIK
710 720 730 740 750
ENKKLDGEEL NKIIIDNDKM GDMKKNIKEV IKKMKKKQSK GSYKTYKNVL
760 770 780 790 800
KSVSEHKELK TQKKADENKI VADNNEKSSN NSLDKNNTQG SIDEKGYKNN
810 820 830 840 850
NNNNNNMVKN INELFEENFP EYKKYDNENN DFVKTKENYF DNFNEVIDIS
860 870 880
HIKNVDEMKK FNIFEHNLNK LFLFDIFKSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99556.1 |
RefSeqi | XP_001350791.1, XM_001350755.1 |
Genome annotation databases
EnsemblProtistsi | CZT99556; CZT99556; PF3D7_1239700 |
GeneDBi | PF3D7_1239700.1:pep |
GeneIDi | 811437 |
KEGGi | pfa:PF3D7_1239700 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99556.1 |
RefSeqi | XP_001350791.1, XM_001350755.1 |
3D structure databases
SMRi | Q8I526 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8I526, 2 interactors |
PTM databases
SwissPalmi | Q8I526 |
Proteomic databases
PRIDEi | Q8I526 |
Genome annotation databases
EnsemblProtistsi | CZT99556; CZT99556; PF3D7_1239700 |
GeneDBi | PF3D7_1239700.1:pep |
GeneIDi | 811437 |
KEGGi | pfa:PF3D7_1239700 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1239700 |
Phylogenomic databases
HOGENOMi | CLU_000688_11_0_1 |
OMAi | NKKWNYF |
Family and domain databases
Gene3Di | 1.20.58.760, 1 hit |
HAMAPi | MF_01458, FtsH, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR005936, FtsH IPR027417, P-loop_NTPase IPR000642, Peptidase_M41 IPR037219, Peptidase_M41-like |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF01434, Peptidase_M41, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF140990, SSF140990, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01241, FtsH_fam, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I526_PLAF7 | |
Accessioni | Q8I526Primary (citable) accession number: Q8I526 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | October 7, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |