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UniProtKB - Q8I4X0 (ACT1_PLAF7)
Protein
Actin-1
Gene
PFL2215w
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- structural constituent of cytoskeleton Source: UniProtKB
GO - Biological processi
- actin polymerization-dependent cell motility involved in migration of symbiont in host Source: UniProtKB
- cytoskeleton organization Source: GeneDB
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-PFA-114608, Platelet degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-1Alternative name(s): Actin I |
Gene namesi | ORF Names:PFL2215w |
Organismi | Plasmodium falciparum (isolate 3D7) |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1246200 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- actin filament Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233389 | 1 – 376 | Actin-1Add BLAST | 376 |
Proteomic databases
PRIDEi | Q8I4X0 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 1206865, 5 interactors |
IntActi | Q8I4X0, 6 interactors |
STRINGi | 5833.PFL2215w |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8I4X0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the actin family.Curated
Phylogenomic databases
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | Q8I4X0 |
OMAi | FHTTAER |
PhylomeDBi | Q8I4X0 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I4X0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEEDVQALV VDNGSGNVKA GVAGDDAPRS VFPSIVGRPK NPGIMVGMEE
60 70 80 90 100
KDAFVGDEAQ TKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRAAPE
110 120 130 140 150
EHPVLLTEAP LNPKGNRERM TQIMFESFNV PAMYVAIQAV LSLYSSGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAIMRLD LAGRDLTEYL MKILHERGYG
210 220 230 240 250
FSTSAEKEIV RDIKEKLCYI ALNFDEEMKT SEQSSDIEKS YELPDGNIIT
260 270 280 290 300
VGNERFRCPE ALFQPSFLGK EAAGIHTTTF NSIKKCDVDI RKDLYGNIVL
310 320 330 340 350
SGGTTMYEGI GERLTRDITT LAPSTMKIKV VAPPERKYSV WIGGSILSSL
360 370
STFQQMWITK EEYDESGPSI VHRKCF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014188 Genomic DNA Translation: AAN36527.1 |
PIRi | S12628 |
RefSeqi | XP_001350847.1, XM_001350811.1 |
Genome annotation databases
EnsemblProtistsi | CZT99616; CZT99616; PF3D7_1246200 |
GeneIDi | 811495 |
KEGGi | pfa:PF3D7_1246200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014188 Genomic DNA Translation: AAN36527.1 |
PIRi | S12628 |
RefSeqi | XP_001350847.1, XM_001350811.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5MVV | X-ray | 1.40 | A | 1-376 | [»] | |
6I4D | X-ray | 1.24 | A | 1-376 | [»] | |
6I4E | X-ray | 1.22 | A | 1-376 | [»] | |
6I4F | X-ray | 1.50 | A | 1-376 | [»] | |
6I4G | X-ray | 2.00 | A/B | 1-376 | [»] | |
6I4H | X-ray | 1.40 | A | 1-376 | [»] | |
6I4I | X-ray | 1.90 | A | 1-376 | [»] | |
6I4J | X-ray | 1.50 | A | 1-376 | [»] | |
6I4K | X-ray | 1.83 | A | 1-376 | [»] | |
6I4L | X-ray | 1.83 | A | 1-376 | [»] | |
6TU4 | electron microscopy | 2.60 | A/B/C/D/F | 1-376 | [»] | |
6TU7 | electron microscopy | 3.10 | BP1/CP1/DP1/EP1 | 1-376 | [»] | |
7ALN | electron microscopy | 3.77 | A/B/C/D/E | 1-376 | [»] | |
SMRi | Q8I4X0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 1206865, 5 interactors |
IntActi | Q8I4X0, 6 interactors |
STRINGi | 5833.PFL2215w |
Proteomic databases
PRIDEi | Q8I4X0 |
Genome annotation databases
EnsemblProtistsi | CZT99616; CZT99616; PF3D7_1246200 |
GeneIDi | 811495 |
KEGGi | pfa:PF3D7_1246200 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1246200 |
Phylogenomic databases
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | Q8I4X0 |
OMAi | FHTTAER |
PhylomeDBi | Q8I4X0 |
Enzyme and pathway databases
Reactomei | R-PFA-114608, Platelet degranulation |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACT1_PLAF7 | |
Accessioni | Q8I4X0Primary (citable) accession number: Q8I4X0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families