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Protein

Actin-1

Gene

PFL2215w

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-1
Alternative name(s):
Actin I
Gene namesi
ORF Names:PFL2215w
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1246200

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333891 – 376Actin-1Add BLAST376

Proteomic databases

PRIDEiQ8I4X0

Interactioni

Protein-protein interaction databases

BioGridi1206865, 5 interactors
IntActiQ8I4X0, 6 interactors

Structurei

Secondary structure

1376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8I4X0
SMRiQ8I4X0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

HOGENOMiHOG000233339
InParanoidiQ8I4X0
KOiK10355
OMAiMERGYPF
PhylomeDBiQ8I4X0

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8I4X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEEDVQALV VDNGSGNVKA GVAGDDAPRS VFPSIVGRPK NPGIMVGMEE
60 70 80 90 100
KDAFVGDEAQ TKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRAAPE
110 120 130 140 150
EHPVLLTEAP LNPKGNRERM TQIMFESFNV PAMYVAIQAV LSLYSSGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAIMRLD LAGRDLTEYL MKILHERGYG
210 220 230 240 250
FSTSAEKEIV RDIKEKLCYI ALNFDEEMKT SEQSSDIEKS YELPDGNIIT
260 270 280 290 300
VGNERFRCPE ALFQPSFLGK EAAGIHTTTF NSIKKCDVDI RKDLYGNIVL
310 320 330 340 350
SGGTTMYEGI GERLTRDITT LAPSTMKIKV VAPPERKYSV WIGGSILSSL
360 370
STFQQMWITK EEYDESGPSI VHRKCF
Length:376
Mass (Da):41,871
Last modified:March 1, 2003 - v1
Checksum:iEC526236FB47148A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA Translation: AAN36527.1
PIRiS12628
RefSeqiXP_001350847.1, XM_001350811.1

Genome annotation databases

GeneDBiPF3D7_1246200.1:pep
GeneIDi811495
KEGGipfa:PF3D7_1246200

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014188 Genomic DNA Translation: AAN36527.1
PIRiS12628
RefSeqiXP_001350847.1, XM_001350811.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MVVX-ray1.40A1-376[»]
ProteinModelPortaliQ8I4X0
SMRiQ8I4X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1206865, 5 interactors
IntActiQ8I4X0, 6 interactors

Proteomic databases

PRIDEiQ8I4X0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiPF3D7_1246200.1:pep
GeneIDi811495
KEGGipfa:PF3D7_1246200

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1246200

Phylogenomic databases

HOGENOMiHOG000233339
InParanoidiQ8I4X0
KOiK10355
OMAiMERGYPF
PhylomeDBiQ8I4X0

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACT1_PLAF7
AccessioniPrimary (citable) accession number: Q8I4X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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