UniProtKB - Q8I4S1 (Q8I4S1_PLAF7)
Protein
dTMP kinase
Gene
PF3D7_1251300
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
- EC:2.7.4.9ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 145 | ADPCombined sources | 1 | |
Binding sitei | 182 | ADP; via carbonyl oxygenCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 23 | ADPCombined sources | 6 |
GO - Molecular functioni
- ATP binding Source: InterPro
- nucleoside diphosphate kinase activity Source: GO_Central
- thymidylate kinase activity Source: GeneDB
- uridylate kinase activity Source: GO_Central
GO - Biological processi
- dTDP biosynthetic process Source: GO_Central
- dTTP biosynthetic process Source: GeneDB
- dUDP biosynthetic process Source: GeneDB
Keywordsi
Molecular function | KinaseImported, Transferase |
Ligand | Nucleotide-bindingCombined sources |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1251300Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1251300 |
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: GO_Central
- cytosol Source: GO_Central
- mitochondrion Source: GO_Central
- nucleus Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 191 | Thymidylate_kinInterPro annotationAdd BLAST | 179 |
Sequence similaritiesi
Belongs to the thymidylate kinase family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_049131_3_2_1 |
OMAi | YETSSFQ |
Family and domain databases
HAMAPi | MF_00165, Thymidylate_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR039430, Thymidylate_kin-like_dom IPR018095, Thymidylate_kin_CS IPR018094, Thymidylate_kinase |
Pfami | View protein in Pfam PF02223, Thymidylate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00041, DTMP_kinase, 1 hit |
PROSITEi | View protein in PROSITE PS01331, THYMIDYLATE_KINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I4S1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDDKKKGKF IVFEGLDRSG KSTQSKLLVE YLKNNNVEVK HLYFPNRETG
60 70 80 90 100
IGQIISKYLK MENSMSNETI HLLFSANRWE HMNEIKSLLL KGIWVVCDRY
110 120 130 140 150
AYSGVAYSSG ALNLNKTWCM NPDQGLIKPD VVFYLNVPPN YAQNRSDYGE
160 170 180 190 200
EIYEKVETQK KIYETYKHFA HEDYWINIDA TRKIEDIHND IVKEVTKIKV
210
EPEEFNFLWS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99668.1 |
RefSeqi | XP_001350897.1, XM_001350861.1 |
Genome annotation databases
EnsemblProtistsi | CZT99668; CZT99668; PF3D7_1251300 |
GeneDBi | PF3D7_1251300.1:pep |
GeneIDi | 811545 |
KEGGi | pfa:PF3D7_1251300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99668.1 |
RefSeqi | XP_001350897.1, XM_001350861.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WWF | X-ray | 1.89 | A/B/C | 1-210 | [»] | |
2WWG | X-ray | 2.40 | A/B/C | 1-210 | [»] | |
2WWH | X-ray | 2.70 | A/B/C | 1-210 | [»] | |
2WWI | X-ray | 2.99 | A/B/C | 1-210 | [»] | |
2YOF | X-ray | 1.82 | A/B/C | 1-210 | [»] | |
2YOG | X-ray | 1.50 | A/B | 1-210 | [»] | |
2YOH | X-ray | 1.60 | A/B | 1-210 | [»] | |
SMRi | Q8I4S1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | Q8I4S1 |
ChEMBLi | CHEMBL2176852 |
PTM databases
SwissPalmi | Q8I4S1 |
Proteomic databases
PRIDEi | Q8I4S1 |
Genome annotation databases
EnsemblProtistsi | CZT99668; CZT99668; PF3D7_1251300 |
GeneDBi | PF3D7_1251300.1:pep |
GeneIDi | 811545 |
KEGGi | pfa:PF3D7_1251300 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1251300 |
Phylogenomic databases
HOGENOMi | CLU_049131_3_2_1 |
OMAi | YETSSFQ |
Family and domain databases
HAMAPi | MF_00165, Thymidylate_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR039430, Thymidylate_kin-like_dom IPR018095, Thymidylate_kin_CS IPR018094, Thymidylate_kinase |
Pfami | View protein in Pfam PF02223, Thymidylate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00041, DTMP_kinase, 1 hit |
PROSITEi | View protein in PROSITE PS01331, THYMIDYLATE_KINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I4S1_PLAF7 | |
Accessioni | Q8I4S1Primary (citable) accession number: Q8I4S1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |