UniProtKB - Q8I4S1 (Q8I4S1_PLAF7)

BLAST

>tr|Q8I4S1|Q8I4S1_PLAF7 Thymidylate kinase OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1251300 PE=1 SV=1
MTDDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIGQIISKYLK
MENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAYSGVAYSSGALNLNKTWCM
NPDQGLIKPDVVFYLNVPPNYAQNRSDYGEEIYEKVETQKKIYETYKHFAHEDYWINIDA
TRKIEDIHNDIVKEVTKIKVEPEEFNFLWS

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History
Entry version 113 (12 Sep 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Submitted name:

Thymidylate kinase

Gene

PF3D7_1251300

Organism

Plasmodium falciparum (isolate 3D7)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	145	ADPCombined sources		1
Binding siteⁱ	182	ADP; via carbonyl oxygenCombined sources		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	18 – 23	ADPCombined sources		6

GO - Molecular functionⁱ

ATP binding Source: InterPro
thymidylate kinase activity
Source: GeneDB
Inferred from direct assayⁱ
- 18477629
uridylate kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dTDP biosynthetic process Source: GO_Central
dTTP biosynthetic process
Source: GeneDB
Inferred from direct assayⁱ
- 18477629
dUDP biosynthetic process
Source: GeneDB
Inferred from direct assayⁱ
- 18477629

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinaseImported, Transferase
Ligand	Nucleotide-bindingCombined sources

Enzyme and pathway databases

Reactomeⁱ	R-PFA-499943 Interconversion of nucleotide di- and triphosphates

Reactomeⁱ

R-PFA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Thymidylate kinaseImported (EC:2.7.4.9Imported)
Gene namesⁱ	ORF Names:PF3D7_1251300Imported
Organismⁱ	Plasmodium falciparum (isolate 3D7)Imported
Taxonomic identifierⁱ	36329 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum
Proteomesⁱ	UP000001450 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	PlasmoDB:PF3D7_1251300

EuPathDBⁱ

PlasmoDB:PF3D7_1251300

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central

View the complete GO annotation on QuickGO ...

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2176852

ChEMBLⁱ

CHEMBL2176852

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q8I4S1

PRIDEⁱ

Q8I4S1

Structureⁱ

3D structure databases

SMRⁱ	Q8I4S1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K00943
OMAⁱ	TPIGQMI

Family and domain databases

HAMAPⁱ	MF_00165 Thymidylate_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR018095 Thymidylate_kin_CS IPR018094 Thymidylate_kinase
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00041 DTMP_kinase, 1 hit
PROSITEⁱ	View protein in PROSITE PS01331 THYMIDYLATE_KINASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8I4S1-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTDDKKKGKF IVFEGLDRSG KSTQSKLLVE YLKNNNVEVK HLYFPNRETG 
        60         70         80         90        100
IGQIISKYLK MENSMSNETI HLLFSANRWE HMNEIKSLLL KGIWVVCDRY 
       110        120        130        140        150
AYSGVAYSSG ALNLNKTWCM NPDQGLIKPD VVFYLNVPPN YAQNRSDYGE 
       160        170        180        190        200
EIYEKVETQK KIYETYKHFA HEDYWINIDA TRKIEDIHND IVKEVTKIKV 
       210
EPEEFNFLWS

Length:210

Mass (Da):24,691

Last modified:March 1, 2003 - v1

Checksum:ⁱE9329D393B685FB3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LN999947 Genomic DNA Translation: CZT99668.1
NCBI Reference Sequences More...RefSeqⁱ	XP_001350897.1, XM_001350861.1

Genome annotation databases

EnsemblProtistsⁱ	CZT99668; CZT99668; PF3D7_1251300
GeneDBⁱ	PF3D7_1251300.1:pep
GeneIDⁱ	811545
KEGGⁱ	pfa:PF3D7_1251300

Protein	Similar proteins		Species	Score	Length	Source
Q8I4S1	Thymidylate kinase		PLARE		210	UniRef100_A0A060RWN7
Uncharacterized protein		PLAF4		210
Thymidylate kinase		Plasmodium sp. gorilla clade G1		210
Thymidylate kinase		PLAFO		210
Thymidylate kinase		PLAF8		210
+4

Protein	Similar proteins		Species	Score	Length	Source
Q8I4S1	Thymidylate kinase		PLARE		210	UniRef90_A0A060RWN7
Uncharacterized protein		PLAF4		210
Thymidylate kinase		Plasmodium sp. gorilla clade G1		210
Thymidylate kinase		PLAFO		210
Thymidylate kinase		PLAF8		210
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8I4S1	Thymidylate kinase		PLARE		210	UniRef50_A0A060RWN7
Uncharacterized protein		PLAF4		210
Thymidylate kinase		Plasmodium sp. gorilla clade G1		210
Thymidylate kinase		PLAFO		210
Thymidylate kinase		PLAF8		210
+12

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	LN999947 Genomic DNA Translation: CZT99668.1
RefSeqⁱ	XP_001350897.1, XM_001350861.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2WWF	X-ray	1.89	A/B/C	1-210	[»]
	2WWG	X-ray	2.40	A/B/C	1-210	[»]
	2WWH	X-ray	2.70	A/B/C	1-210	[»]
	2WWI	X-ray	2.99	A/B/C	1-210	[»]
	2YOF	X-ray	1.82	A/B/C	1-210	[»]
	2YOG	X-ray	1.50	A/B	1-210	[»]
	2YOH	X-ray	1.60	A/B	1-210	[»]
SMRⁱ	Q8I4S1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

ChEMBLⁱ	CHEMBL2176852

ChEMBLⁱ

CHEMBL2176852

Proteomic databases

PRIDEⁱ	Q8I4S1

PRIDEⁱ

Q8I4S1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	CZT99668; CZT99668; PF3D7_1251300
GeneDBⁱ	PF3D7_1251300.1:pep
GeneIDⁱ	811545
KEGGⁱ	pfa:PF3D7_1251300

Organism-specific databases

EuPathDBⁱ	PlasmoDB:PF3D7_1251300

EuPathDBⁱ

PlasmoDB:PF3D7_1251300

Phylogenomic databases

KOⁱ	K00943
OMAⁱ	TPIGQMI

Enzyme and pathway databases

Reactomeⁱ	R-PFA-499943 Interconversion of nucleotide di- and triphosphates

Reactomeⁱ

R-PFA-499943 Interconversion of nucleotide di- and triphosphates

Family and domain databases

HAMAPⁱ	MF_00165 Thymidylate_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR018095 Thymidylate_kin_CS IPR018094 Thymidylate_kinase
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00041 DTMP_kinase, 1 hit
PROSITEⁱ	View protein in PROSITE PS01331 THYMIDYLATE_KINASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8I4S1_PLAF7
Accessionⁱ	Q8I4S1Primary (citable) accession number: Q8I4S1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2003
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8I4S1 (Q8I4S1_PLAF7)

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Thymidylate kinase

PF3D7_1251300

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ