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Entry version 88 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Rhoptry neck protein 3

Gene

PF3D7_1252100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • entry into host Source: GeneDB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rhoptry neck protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1252100Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_1252100

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei277 – 298HelicalSequence analysisAdd BLAST22
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638, Artenimol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501947669822 – 2215Sequence analysisAdd BLAST2194

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I4R5

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I4R5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I4R5, 6 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1690 – 1727DisorderedSequence analysisAdd BLAST38
Regioni1756 – 1841DisorderedSequence analysisAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili390 – 410Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1756 – 1819Polar residuesSequence analysisAdd BLAST64
Compositional biasi1820 – 1841Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_230687_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNIRHIY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8I4R5

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I4R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKYWLYIAY VYLLLNILSK CNKIENNNNK VKNLTVYNND IGQYFKKKDI
60 70 80 90 100
QCKHHIEINQ DSNHNEYSFL SLKASSIFNQ YYVAKLINTL LYRGFHLNVY
110 120 130 140 150
FHKNVAMYES FSRTNFFFYL TILNKKNVKK IVKIISKAER SSNKRKFNVF
160 170 180 190 200
KKYLISEFDY PNFEIDDTVK NEMNQAILVY KKAKSDSYWS VMDALKKDGL
210 220 230 240 250
LLARTFLSVS FVQSLRGIIG LINHKLIDLC FTNAYVFNHV ASFDKLIMNN
260 270 280 290 300
IFGVIMSYVF KSLLLFFYPL IIPFRGAFAF AISAFCITQL GKIVFAIYKN
310 320 330 340 350
LRQLYRISYR KIYSIVLKVK LRNEPELKKY AMKLLYGDAL IMITKIWKLS
360 370 380 390 400
YVNVSEHLNG KNVYPILNNL FEKNLGTGFF DFSNSLFKYV MNYLEEINLL
410 420 430 440 450
NAKSVDVEKE LILNRHNFKL LLKILKITKK SLLYEESYMK ISVANLLTKF
460 470 480 490 500
YTLILVNIEH ISKLNPKEHF YNDLDNEFKH IYQDQMFELF IQKISSDIVR
510 520 530 540 550
KPFIKRNIGR IDKGSIELTL ALIKVKLLHY KPTLNNPYSS LYFDENLKKQ
560 570 580 590 600
LNYAFKLIII GSTSIIASLA NYGERYGVLK QCPLDIVKNL NQQCEYVSFE
610 620 630 640 650
IKKLIFPINI FVNLLIPLFL PYDDVLVDKN IIDEVKKFFN VIIDTDDSYL
660 670 680 690 700
QKYMKTTINT IRKSKDLDIN NVNYEEEMEK IVVQEAHKVI EEINKERRAS
710 720 730 740 750
FKFQDFVVKE DSVVLYNKSG IQYSFKFDHL NRKEDFMRII GSYQFKNPIG
760 770 780 790 800
YQTSQLVFEP QNNHIGSLMV GSNKNTFDGK LSVCHMCYKE DDDSLVVDAI
810 820 830 840 850
FSILWSSGID RFSAFIFASF IGAVKQTYHQ GTSWKRALSN MAPTEFYEMH
860 870 880 890 900
KIFMDKSVYG KEKSQNYFLK NIRKYRFQFS RGSFSRMFRT FLENSLNKIN
910 920 930 940 950
FFNSEEAIII LVMSTLYALY KNIEKFDIPL KETYKLYQQK LIESYYHVDK
960 970 980 990 1000
YSHHYETYTL NIRRKKYNAL VKSEHEKAQE ASQGEGKDEA ENAELKKRVE
1010 1020 1030 1040 1050
KRINFNDIQL TMEDEVVRNT KYLQLELQAK PQEREKIIQY LTYKYKEIPN
1060 1070 1080 1090 1100
HEMFPHLPHQ CYFLLYYNYE PFLEKNLHGL EGVVSKITRK SVLSRYLKNI
1110 1120 1130 1140 1150
NLIQPEKTRF ASIKLKDLIN ILCGTHMFLK KEHITFDEIY KYENSNDALK
1160 1170 1180 1190 1200
HLLIIVALLR IEKRTNRYSW TTYLTLQKQL DERKRYYDTP FKYLFLKISK
1210 1220 1230 1240 1250
VRRFYGSAKK KMLLGFGKKF KGVRFLNILR YTRFFEIMEY AESINEFYPY
1260 1270 1280 1290 1300
CYIKFEDVLT FSNVFYKFKY SLLRYTTSKQ SVRNVVNNFN LSPQTTGNNE
1310 1320 1330 1340 1350
NLLLRIYRFI ELIIKKKYNV DIQHVRKDDK DFNRHAYNKN EYILNDIKFN
1360 1370 1380 1390 1400
PNIEQYLRQL TGFIKLLTDM KFTNFLFLRN LYYFVKFYAV TGDLTYSINN
1410 1420 1430 1440 1450
SSIYLCSRNY LEFILNSIIE FENFKKFMVK IKEKFDIEKY PIDPYNFQTE
1460 1470 1480 1490 1500
CYSIDSVKTY RFFLSDLDKL KSYQDIENLQ NVSSFYKDYL YMGLFYENLD
1510 1520 1530 1540 1550
VRNLNVYYNF NKKKNQDHKA HGSNVFLDGG LSLSKNMSFS DINDLSESIQ
1560 1570 1580 1590 1600
NYLYLEKFLA DSNIPSIPYQ GFSVRRVNDG MHVTYNNRST TPPLYKDNVL
1610 1620 1630 1640 1650
DQFELVGKSL ISEYFQKVKC SFIQYPFNLY YWLVLNPGKP NISLSSKTGL
1660 1670 1680 1690 1700
IKEDDLIPKT VEEKLKEEEE HDIKIVENIL SEDIFDFKDK SDDDQSTTAD
1710 1720 1730 1740 1750
VLSTDTDDSE TDAEKTSNNS NTLHKKETPA MKYNMNIAQD EINRQNDVSK
1760 1770 1780 1790 1800
NTTYAENNEY TSENITKPSD QNTENYGTKM PSPSFIQIDK VNQQDQQNDA
1810 1820 1830 1840 1850
HIESSKNTQE NLNYDDNTNM YEENKNDKKN KKLNNNTKEI SFLERRETNP
1860 1870 1880 1890 1900
IPFSSNMINE KNKEAHKEHY GNFNRPYNIY VPKKDIFRNF HLVVKVVHAL
1910 1920 1930 1940 1950
ISLNKFSMVS PDTILKKGIE SMKKKHSLKM IKNINPFIHK MILDMNETIQ
1960 1970 1980 1990 2000
KLKSDSEKAY GGPKADIISL YKIVEFQLFN QYIIYPPLKR LTKKELKYIL
2010 2020 2030 2040 2050
DVVNQGYYFY LKNVITKLKR ENLQKSKVVK IFNNFQEFSN LLDDDGVDKL
2060 2070 2080 2090 2100
YNIFTETFKC KNIKCFDLLF QGFLTEQYNN IVYRYTHDHD AMNSYNDNIF
2110 2120 2130 2140 2150
NNKELLNKIF RRAYDNYFIT PVKNNQPKKL ISLEKPSLEQ PVLTLEEFAY
2160 2170 2180 2190 2200
GFHEFGNKIE KWRSMLTLFN IRHIYINICH MLLSVKHSIQ RSHRVFMHKF
2210
GFFGIFRRKR EIYIP
Length:2,215
Mass (Da):263,155
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i521C7B47A199064E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99674.1

NCBI Reference Sequences

More...
RefSeqi
XP_001350903.1, XM_001350867.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT99674; CZT99674; PF3D7_1252100

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1252100.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
811551

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1252100

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99674.1
RefSeqiXP_001350903.1, XM_001350867.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8I4R5, 6 interactors

Chemistry databases

DrugBankiDB11638, Artenimol

PTM databases

SwissPalmiQ8I4R5

Proteomic databases

PRIDEiQ8I4R5

Genome annotation databases

EnsemblProtistsiCZT99674; CZT99674; PF3D7_1252100
GeneDBiPF3D7_1252100.1:pep
GeneIDi811551
KEGGipfa:PF3D7_1252100

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_1252100

Phylogenomic databases

HOGENOMiCLU_230687_0_0_1
OMAiFNIRHIY
PhylomeDBiQ8I4R5

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I4R5_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I4R5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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