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Entry version 135 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Sorting nexin lst-4

Gene

lst-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-432722, Golgi Associated Vesicle Biogenesis
R-CEL-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8I4E2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin lst-4By similarity
Alternative name(s):
Lateral signaling target protein 42 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lst-4Imported
ORF Names:Y37A1B.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y37A1B.2a ; CE19071 ; WBGene00003086 ; lst-4
Y37A1B.2b ; CE32245 ; WBGene00003086 ; lst-4
Y37A1B.2c ; CE32246 ; WBGene00003086 ; lst-4
Y37A1B.2d ; CE32247 ; WBGene00003086 ; lst-4
Y37A1B.2e ; CE44602 ; WBGene00003086 ; lst-4
Y37A1B.2f ; CE47745 ; WBGene00003086 ; lst-4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Aberrant vulval development, ectopic vulval induction, retained cell corpses and defective recruitment of dyn-1 and rab-7 to phagosomal surfaces.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi265 – 267RYK → QAA: Defective recruitment to the phagosome. 1 Publication3
Mutagenesisi265R → Q: Defect recruitment by phosphoinositide to phagosomal surface. 1 Publication1
Mutagenesisi494K → E: Defective recruitment to the phagosome. 1 Publication1
Mutagenesisi501R → E: Defective recruitment to the phagosome. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004227721 – 566Sorting nexin lst-4Add BLAST566

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8I4E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8I4E2

PeptideAtlas

More...
PeptideAtlasi
Q8I4E2

PRoteomics IDEntifications database

More...
PRIDEi
Q8I4E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in vulval precursor cells (VPCs) and apoptotic germ cells. Colocalizes with actin, dyn-1 and rab-5 in early phagosomes.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in all 6 vulval precursor cells (VPCs). At the time of inductive signaling, expression forms a gradient in response to inductive signal: expression is low in P6.p, intermediate in P5.p and P7.p and undiminished in P3.p, P4.p, and P8.p. Later, expression becomes strong again in P5.p and P7.p.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003086, Expressed in adult organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8I4E2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Isoform d interacts (via SH3 domain) with dyn-1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
43445, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8I4E2, 6 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y37A1B.2b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I4E2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini227 – 339PXPROSITE-ProRule annotationAdd BLAST113
Domaini362 – 566BARSequence analysisAdd BLAST205

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 115Pro-richSequence analysisAdd BLAST52

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BAR and PX domains are required for recruitment to the phagosome.1 Publication
The SH3 domain is involved in phagosome maturation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Sequence analysis

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2528, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000166896

KEGG Orthology (KO)

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KOi
K17923

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERDPYMG

Database of Orthologous Groups

More...
OrthoDBi
811995at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR001683, Phox
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR014536, Snx9_fam
IPR019497, Sorting_nexin_WASP-bd-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10456, BAR_3_WASP_bdg, 1 hit
PF00787, PX, 1 hit
PF14604, SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF027744, Snx9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312, PX, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform c1 Publication (identifier: Q8I4E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQVKAEYDF QSQPNTGELS ISAGEVLTVI RENIDGGWIE GRNVRGSVGL
60 70 80 90 100
FPESYVTPYQ ASRPPPVLPP PLPPTSSGPP AASSRPFDDW GGASEVAAPP
110 120 130 140 150
SYGAQHHHQP TPSVPEVTRS SYPSQNDDFD DEWTDEDDEQ EPTRPNVQSS
160 170 180 190 200
IGSNSRRDLS RSHSEHGGPD RGSNKVNKNI NRFSNFVKSG VEAYVIGESK
210 220 230 240 250
TTSQISERHE VVMNNGIIQW KPIQQYYTCI VDKPKKESKL KGLKSFIAYS
260 270 280 290 300
ITSSLTNIQR QVSRRYKHFD WLHEQLSAKY VLIPIPPLPE KQVAGRYEED
310 320 330 340 350
LIDHRKHILQ LWVNKICRHP VLSQSEVWLH FISCTDEKDW KNGKRRAEKD
360 370 380 390 400
EYIGGAFLNC ITVPHQPLDP NNVDMQVERF QRSVKTSEEA MRVMQERMNM
410 420 430 440 450
FQKVFAGPVK QNWQKMGSAF KTLQQSFEID ETVASRRLTE ALAYTASEYH
460 470 480 490 500
EIGQVFDAHT KNDMEPVLEN LYSYKGTVQN VPDIIQVHKQ AVQKFRDSEG
510 520 530 540 550
RLSSAEAEKM KQRIDAMSYT VIAEVQHQTA EKVEDMKSTM GTYLKKQAMF
560
YQEVATKLTS LAARYD
Length:566
Mass (Da):64,329
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77CFBE901A3E3B24
GO
Isoform a1 Publication (identifier: Q8I4E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-163: EPTRPNVQSSIGSNSRRDLSRSH → VFLKFYFNFLIVQFLSVLFIPSN
     165-566: Missing.

Show »
Length:164
Mass (Da):18,014
Checksum:i090A42146AAC080C
GO
Isoform b1 Publication (identifier: Q8I4E2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MAQVKAEYDF...TPYQASRPPP → MLFTSSLRKA...FKKSGAISKS

Show »
Length:592
Mass (Da):67,553
Checksum:i156B568888CD5E78
GO
Isoform d1 Publication (identifier: Q8I4E2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-261: Missing.

Show »
Length:564
Mass (Da):64,045
Checksum:i224A0F3052A1CA3D
GO
Isoform e1 Publication (identifier: Q8I4E2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-509: Missing.

Show »
Length:57
Mass (Da):6,580
Checksum:i5AE1F0267B8630F8
GO
Isoform f1 Publication (identifier: Q8I4E2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-79: AQVKAEYDFQ...PPLPPTSSGP → STDDETRSSQ...SNRSHHDQNK
     80-140: Missing.

Show »
Length:505
Mass (Da):58,155
Checksum:i1514E1BFE36F43FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A061AD14A0A061AD14_CAEEL
PX domain-containing protein
lst-4 CELE_Y37A1B.2, Y37A1B.2
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
N1NVC3N1NVC3_CAEEL
PX domain-containing protein
lst-4 CELE_Y37A1B.2, Y37A1B.2
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466281 – 509Missing in isoform e. 1 PublicationAdd BLAST509
Alternative sequenceiVSP_0466291 – 66MAQVK…SRPPP → MLFTSSLRKAVENYPTPPGG SSEDAHRQLLERRRKQMLRR HTCSTLIKQDTSASPHKMKP PILMEEEDEQHSTGKHSSRK SSFKKSGAISKS in isoform b. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_0466302 – 79AQVKA…TSSGP → STDDETRSSQQDGAYPSSKR NGSVGSSTRSTSTKKRLSRQ DSTARRRRLSEERDSRRRVE KSVSSCLSSNRSHHDQNK in isoform f. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_04663180 – 140Missing in isoform f. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_046632141 – 163EPTRP…LSRSH → VFLKFYFNFLIVQFLSVLFI PSN in isoform a. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_046633165 – 566Missing in isoform a. 1 PublicationAdd BLAST402
Alternative sequenceiVSP_046634260 – 261Missing in isoform d. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL023835 Genomic DNA Translation: CAA19486.1
AL023835 Genomic DNA Translation: CAA19487.2
AL023835 Genomic DNA Translation: CAD56253.1
AL023835 Genomic DNA Translation: CAD56254.1
AL023835 Genomic DNA Translation: CBK19491.1
AL023835 Genomic DNA Translation: CCM09420.1

NCBI Reference Sequences

More...
RefSeqi
NP_001255779.1, NM_001268850.1 [Q8I4E2-5]
NP_001263811.1, NM_001276882.1 [Q8I4E2-6]
NP_502693.2, NM_070292.4 [Q8I4E2-1]
NP_502694.1, NM_070293.5 [Q8I4E2-2]
NP_502695.2, NM_070294.4 [Q8I4E2-3]
NP_872090.1, NM_182290.3 [Q8I4E2-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y37A1B.2a.1; Y37A1B.2a.1; WBGene00003086 [Q8I4E2-2]
Y37A1B.2b.1; Y37A1B.2b.1; WBGene00003086 [Q8I4E2-3]
Y37A1B.2c.1; Y37A1B.2c.1; WBGene00003086 [Q8I4E2-1]
Y37A1B.2d.1; Y37A1B.2d.1; WBGene00003086 [Q8I4E2-4]
Y37A1B.2e.1; Y37A1B.2e.1; WBGene00003086 [Q8I4E2-5]
Y37A1B.2f.1; Y37A1B.2f.1; WBGene00003086 [Q8I4E2-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178361

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_Y37A1B.2

UCSC genome browser

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UCSCi
Y37A1B.2b, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023835 Genomic DNA Translation: CAA19486.1
AL023835 Genomic DNA Translation: CAA19487.2
AL023835 Genomic DNA Translation: CAD56253.1
AL023835 Genomic DNA Translation: CAD56254.1
AL023835 Genomic DNA Translation: CBK19491.1
AL023835 Genomic DNA Translation: CCM09420.1
RefSeqiNP_001255779.1, NM_001268850.1 [Q8I4E2-5]
NP_001263811.1, NM_001276882.1 [Q8I4E2-6]
NP_502693.2, NM_070292.4 [Q8I4E2-1]
NP_502694.1, NM_070293.5 [Q8I4E2-2]
NP_502695.2, NM_070294.4 [Q8I4E2-3]
NP_872090.1, NM_182290.3 [Q8I4E2-4]

3D structure databases

SMRiQ8I4E2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi43445, 2 interactors
IntActiQ8I4E2, 6 interactors
STRINGi6239.Y37A1B.2b

Proteomic databases

EPDiQ8I4E2
PaxDbiQ8I4E2
PeptideAtlasiQ8I4E2
PRIDEiQ8I4E2

Genome annotation databases

EnsemblMetazoaiY37A1B.2a.1; Y37A1B.2a.1; WBGene00003086 [Q8I4E2-2]
Y37A1B.2b.1; Y37A1B.2b.1; WBGene00003086 [Q8I4E2-3]
Y37A1B.2c.1; Y37A1B.2c.1; WBGene00003086 [Q8I4E2-1]
Y37A1B.2d.1; Y37A1B.2d.1; WBGene00003086 [Q8I4E2-4]
Y37A1B.2e.1; Y37A1B.2e.1; WBGene00003086 [Q8I4E2-5]
Y37A1B.2f.1; Y37A1B.2f.1; WBGene00003086 [Q8I4E2-6]
GeneIDi178361
KEGGicel:CELE_Y37A1B.2
UCSCiY37A1B.2b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
178361
WormBaseiY37A1B.2a ; CE19071 ; WBGene00003086 ; lst-4
Y37A1B.2b ; CE32245 ; WBGene00003086 ; lst-4
Y37A1B.2c ; CE32246 ; WBGene00003086 ; lst-4
Y37A1B.2d ; CE32247 ; WBGene00003086 ; lst-4
Y37A1B.2e ; CE44602 ; WBGene00003086 ; lst-4
Y37A1B.2f ; CE47745 ; WBGene00003086 ; lst-4

Phylogenomic databases

eggNOGiKOG2528, Eukaryota
GeneTreeiENSGT00940000166896
KOiK17923
OMAiERDPYMG
OrthoDBi811995at2759

Enzyme and pathway databases

ReactomeiR-CEL-432722, Golgi Associated Vesicle Biogenesis
R-CEL-8856828, Clathrin-mediated endocytosis
SignaLinkiQ8I4E2

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8I4E2

Gene expression databases

BgeeiWBGene00003086, Expressed in adult organism and 5 other tissues
ExpressionAtlasiQ8I4E2, baseline and differential

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR001683, Phox
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR014536, Snx9_fam
IPR019497, Sorting_nexin_WASP-bd-dom
PfamiView protein in Pfam
PF10456, BAR_3_WASP_bdg, 1 hit
PF00787, PX, 1 hit
PF14604, SH3_9, 1 hit
PIRSFiPIRSF027744, Snx9, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00312, PX, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLST4_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I4E2
Secondary accession number(s): D3NQ98
, J7SA60, Q8I4E1, Q9XXG2, Q9XXG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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