PF3D7_0509800

Functionⁱ

GO - Molecular functionⁱ

1-phosphatidylinositol 4-kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phosphatidylinositol-mediated signaling Source: GO_Central
response to drug
Source: GeneDB
Inferred from direct assayⁱ
- 24284631

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinasePROSITE-ProRule annotationSAAS annotationImported, Transferase

Molecular function

KinasePROSITE-ProRule annotationSAAS annotationImported, Transferase

Enzyme and pathway databases

Reactomeⁱ	R-PFA-1660514 Synthesis of PIPs at the Golgi membrane

Reactomeⁱ

R-PFA-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Phosphatidylinositol 4-kinaseImported (EC:2.7.1.67Imported)
Gene namesⁱ	ORF Names:PF3D7_0509800Imported
Organismⁱ	Plasmodium falciparum (isolate 3D7)Imported
Taxonomic identifierⁱ	36329 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum
Proteomesⁱ	UP000001450 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	PlasmoDB:PF3D7_0509800

EuPathDBⁱ

PlasmoDB:PF3D7_0509800

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central
membrane Source: GO_Central

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q8I406

PRIDEⁱ

Q8I406

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8I406, 1 interactor

IntActⁱ

Q8I406, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8I406
SMRⁱ	Q8I406
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	284 – 484	PIK helicalInterPro annotationAdd BLAST		201
Domainⁱ	1303 – 1559	PI3K/PI4KInterPro annotationAdd BLAST		257

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	222 – 249	Sequence analysisAdd BLAST	28
Coiled coilⁱ	951 – 983	Sequence analysisAdd BLAST	33
Coiled coilⁱ	1058 – 1078	Sequence analysisAdd BLAST	21

Sequence similaritiesⁱ

Belongs to the PI3/PI4-kinase family.SAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMⁱ	HOG000284115
InParanoidⁱ	Q8I406
KEGG Orthology (KO) More...KOⁱ	K19801
OMAⁱ	HEYLVNS

Family and domain databases

Gene3Dⁱ	1.10.1070.11, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000403 PI3/4_kinase_cat_dom IPR036940 PI3/4_kinase_cat_sf IPR018936 PI3/4_kinase_CS IPR015433 PI_Kinase IPR001263 PInositide-3_kin_accessory_dom
PANTHERⁱ	PTHR10048 PTHR10048, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00454 PI3_PI4_kinase, 2 hits
SMARTⁱ	View protein in SMART SM00146 PI3Kc, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00915 PI3_4_KINASE_1, 1 hit PS00916 PI3_4_KINASE_2, 1 hit PS50290 PI3_4_KINASE_3, 1 hit PS51545 PIK_HELICAL, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8I406-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEDDKDNNIT KENLNEVDIE NSQHPIIEEK NLKEEGVKDE GGKVFLKGEP 
        60         70         80         90        100
IHKHLYKHSY NTQVYKDEVT HMRLRNRENK NLNENNSDDN KKVNKKNGCV 
       110        120        130        140        150
DINMNEHTNK KEDGDDDDGD DDDGDDDDDD DDDDGDDDGD DDGDDDGDDG 
       160        170        180        190        200
DDDSNSNDDI KNNHKYNNDD YHKNMIKLHC TSPKKKEHSI NNNNIVSHNE 
       210        220        230        240        250
IEENLKDHTL ITNDEEKNIK IIEMYEKKLE NEEIKKQNKE DANENNKSQI 
       260        270        280        290        300
RESISKIFKE CPTSKPKIIN EINNETKYDN NNNNNNNNNN NNNNSNNNNK 
       310        320        330        340        350
NNNKNNNKNS SYNNYYYNNI YNCNNMKENN HIDGDKNNIY ETNNYSDSEK 
       360        370        380        390        400
NKSSDTEKNK LKLNNKNTLK EGSLLRLFRC EYFDTHLHIR YLYDRKEVGV 
       410        420        430        440        450
HEYLVNSLYT QRKYEDILFY LPQLSQISLV RYESSSLYRF LLEKASKSMH 
       460        470        480        490        500
FALKLSWLYH SIVEDNSSKY KDLAQRMIQE IEMAVVNCKP LNNECKSFEE 
       510        520        530        540        550
NKQSYLLDLA YPLLFKRKFI LKKIKTNEKL NKIKMYNKCL NNSYNSYTLK 
       560        570        580        590        600
NLHVSNPIEM DTTSFLRNHK NSNDSTLSQG LPNKSSNDDN CNVLKREDHQ 
       610        620        630        640        650
DVINISSEEN EERDINKNLK EEVTTLDDNK ISRENNLQNL QSEKKTPILK 
       660        670        680        690        700
RKNLKQAHTT PCPKLPPCYI INSGSLSIAR AKVKLPSTYS KLGNPLSFSK 
       710        720        730        740        750
FSLPDFNYSY DMIEELQQFF MKQRRCDYFS LLNNFINLLI SVSNLLAAEP 
       760        770        780        790        800
DIDLRNELLR RFIYSLNSWM NMRRCIVACC ENIFAMTGLC IPLESMSSST 
       810        820        830        840        850
FNHDTNNRLS YNNLQILHFN NEECKIFFSK KRAPYLLMFE VADLDEDISH 
       860        870        880        890        900
ISDNIFYTKK SLFFQQDNNN NNNNDNNNNN NNNNNNNNNY NCNNNNYNSD 
       910        920        930        940        950
VQSKEPKNVR EEYSRKSLIL SRNFCCSKNY GYYEENLNTF DYENRLSLED 
       960        970        980        990       1000
KKKKNSKKKK YAKEQEQTNN EKLKDKEKER KKKNIFDLNS LKMDDIYVYN 
      1010       1020       1030       1040       1050
CIVNDLRREN LISFTSKEDE NLALIKKCLG LKMVEEEKNE NDDDDNDDDN 
      1060       1070       1080       1090       1100
DDDNDDDNDD YNEEEEDDNY EKKNFEEEQK GNYNNDNINH NEKKKKVPTA 
      1110       1120       1130       1140       1150
NDNLSSSSFC VKKNYLLNSR SVSMPSYLNN NLEKCDTSSY DNTSNNIKTS 
      1160       1170       1180       1190       1200
IETISNGIDD IQVEKNIEKN ETFEEMKRKN SNNEFIDYNE HMVKLSPYYT 
      1210       1220       1230       1240       1250
TTNHRGKNKN DDTDDNSDDD NINNYNNNNN SGNNNQDNTI SNFPNNILDL 
      1260       1270       1280       1290       1300
SEYFKPENYL NEEFKKKNCK IIKRLLWGEL FEEKKKRIRK VSPYGKLKTW 
      1310       1320       1330       1340       1350
DLKCVIIKGG DDLRQELLAS QLIKQFKIIF ENAGLPLWLR PYEILVTGSN 
      1360       1370       1380       1390       1400
SGIIEYVNDT CSVDSLKRKF GADSISTIFN IVFSDYIFEA KKNFIESHAA 
      1410       1420       1430       1440       1450
YSLISYLLQV KDRHNGNLLL DSDGHLIHID YGFMLTNSPG NVNFETSPFK 
      1460       1470       1480       1490       1500
LTQEYLDIMD GEKSDNYEYF RRLIVSGFLE ARKHSEEIIL FVELMMPALK 
      1510       1520       1530       1540       1550
IPCFANGTQF CIESLKERFM TNLTVDVCIQ RINALIEASI NNFRSVQYDY 

FQRITNGIM

Length:1,559

Mass (Da):182,664

Last modified:March 1, 2003 - v1

Checksum:ⁱ9087140E1E176E96

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844504 Genomic DNA Translation: CAD51463.1
NCBI Reference Sequences More...RefSeqⁱ	XP_001351656.1, XM_001351620.1

Genome annotation databases

EnsemblProtistsⁱ	CAD51463; CAD51463; PF3D7_0509800
GeneDBⁱ	PF3D7_0509800.1:pep
GeneIDⁱ	812838
KEGGⁱ	pfa:PF3D7_0509800

Protein	Similar proteins		Species	Score	Length	Source
Q8I406	Phosphatidylinositol 4-kinase		PLAFO		1559	UniRef100_Q8I406

Protein	Similar proteins		Species	Score	Length	Source
Q8I406	Phosphatidylinositol 4-kinase		PLAFO		1559	UniRef90_Q8I406
Uncharacterized protein		PLAFX		1575
Phosphatidylinositol 4-kinase		Plasmodium sp. gorilla clade G1		1565
Phosphatidylinositol 4-kinase		Plasmodium falciparum IGH-CR14		1562
Uncharacterized protein		PLAF4		1557
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8I406	Phosphatidylinositol 4-kinase		PLAFO		1559	UniRef50_Q8I406
Uncharacterized protein		PLAFX		1575
Phosphatidylinositol 4-kinase		Plasmodium sp. gorilla clade G1		1565
Phosphatidylinositol 4-kinase		Plasmodium falciparum IGH-CR14		1562
Uncharacterized protein		PLAF4		1557
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844504 Genomic DNA Translation: CAD51463.1
RefSeqⁱ	XP_001351656.1, XM_001351620.1

3D structure databases

ProteinModelPortalⁱ	Q8I406
SMRⁱ	Q8I406
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8I406, 1 interactor

IntActⁱ

Q8I406, 1 interactor

Proteomic databases

PRIDEⁱ	Q8I406

PRIDEⁱ

Q8I406

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	CAD51463; CAD51463; PF3D7_0509800
GeneDBⁱ	PF3D7_0509800.1:pep
GeneIDⁱ	812838
KEGGⁱ	pfa:PF3D7_0509800

Organism-specific databases

EuPathDBⁱ	PlasmoDB:PF3D7_0509800

EuPathDBⁱ

PlasmoDB:PF3D7_0509800

Phylogenomic databases

HOGENOMⁱ	HOG000284115
InParanoidⁱ	Q8I406
KOⁱ	K19801
OMAⁱ	HEYLVNS

Enzyme and pathway databases

Reactomeⁱ	R-PFA-1660514 Synthesis of PIPs at the Golgi membrane

Reactomeⁱ

R-PFA-1660514 Synthesis of PIPs at the Golgi membrane

Family and domain databases

Gene3Dⁱ	1.10.1070.11, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000403 PI3/4_kinase_cat_dom IPR036940 PI3/4_kinase_cat_sf IPR018936 PI3/4_kinase_CS IPR015433 PI_Kinase IPR001263 PInositide-3_kin_accessory_dom
PANTHERⁱ	PTHR10048 PTHR10048, 1 hit
Pfamⁱ	View protein in Pfam PF00454 PI3_PI4_kinase, 2 hits
SMARTⁱ	View protein in SMART SM00146 PI3Kc, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00915 PI3_4_KINASE_1, 1 hit PS00916 PI3_4_KINASE_2, 1 hit PS50290 PI3_4_KINASE_3, 1 hit PS51545 PIK_HELICAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8I406_PLAF7
Accessionⁱ	Q8I406Primary (citable) accession number: Q8I406
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2003
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8I406 (Q8I406_PLAF7)

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Phosphatidylinositol 4-kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ