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UniProtKB - Q8I406 (Q8I406_PLAF7)

Entry version 138 (25 May 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein
Submitted name:

Phosphatidylinositol 4-kinase

Gene

PF3D7_0509800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-PFA-1660514, Synthesis of PIPs at the Golgi membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphatidylinositol 4-kinaseImported (EC:2.7.1.67Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0509800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		PlasmoDB:PF3D7_0509800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2972

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q8I406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8I406, 1 interactor

STRING: functional protein association networks

More...STRINGi		5833.PFE0485w

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8I406

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8I406

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini284 – 484PIK helicalInterPro annotationAdd BLAST201
Domaini1303 – 1559PI3K/PI4K catalyticInterPro annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 169DisorderedSequence analysisAdd BLAST94
Regioni275 – 314DisorderedSequence analysisAdd BLAST40
Regioni567 – 589DisorderedSequence analysisAdd BLAST23
Regioni867 – 909DisorderedSequence analysisAdd BLAST43
Regioni952 – 978DisorderedSequence analysisAdd BLAST27
Regioni1037 – 1102DisorderedSequence analysisAdd BLAST66
Regioni1200 – 1240DisorderedSequence analysisAdd BLAST41
Regioni1309 – 1315G-loopPROSITE-ProRule annotation7
Regioni1460 – 1484Activation loopPROSITE-ProRule annotationAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili222 – 249Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi76 – 96Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi115 – 155Acidic residuesSequence analysisAdd BLAST41
Compositional biasi867 – 903Polar residuesSequence analysisAdd BLAST37
Compositional biasi960 – 978Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1038 – 1072Acidic residuesSequence analysisAdd BLAST35
Compositional biasi1220 – 1240Polar residuesSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003809_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8I406

Identification of Orthologs from Complete Genome Data

More...OMAi		YNCIVND

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8I406

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit
1.25.40.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR015433, PI_Kinase

The PANTHER Classification System

More...PANTHERi		PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00454, PI3_PI4_kinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51545, PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDKDNNIT KENLNEVDIE NSQHPIIEEK NLKEEGVKDE GGKVFLKGEP 
        60         70         80         90        100
IHKHLYKHSY NTQVYKDEVT HMRLRNRENK NLNENNSDDN KKVNKKNGCV 
       110        120        130        140        150
DINMNEHTNK KEDGDDDDGD DDDGDDDDDD DDDDGDDDGD DDGDDDGDDG 
       160        170        180        190        200
DDDSNSNDDI KNNHKYNNDD YHKNMIKLHC TSPKKKEHSI NNNNIVSHNE 
       210        220        230        240        250
IEENLKDHTL ITNDEEKNIK IIEMYEKKLE NEEIKKQNKE DANENNKSQI 
       260        270        280        290        300
RESISKIFKE CPTSKPKIIN EINNETKYDN NNNNNNNNNN NNNNSNNNNK 
       310        320        330        340        350
NNNKNNNKNS SYNNYYYNNI YNCNNMKENN HIDGDKNNIY ETNNYSDSEK 
       360        370        380        390        400
NKSSDTEKNK LKLNNKNTLK EGSLLRLFRC EYFDTHLHIR YLYDRKEVGV 
       410        420        430        440        450
HEYLVNSLYT QRKYEDILFY LPQLSQISLV RYESSSLYRF LLEKASKSMH 
       460        470        480        490        500
FALKLSWLYH SIVEDNSSKY KDLAQRMIQE IEMAVVNCKP LNNECKSFEE 
       510        520        530        540        550
NKQSYLLDLA YPLLFKRKFI LKKIKTNEKL NKIKMYNKCL NNSYNSYTLK 
       560        570        580        590        600
NLHVSNPIEM DTTSFLRNHK NSNDSTLSQG LPNKSSNDDN CNVLKREDHQ 
       610        620        630        640        650
DVINISSEEN EERDINKNLK EEVTTLDDNK ISRENNLQNL QSEKKTPILK 
       660        670        680        690        700
RKNLKQAHTT PCPKLPPCYI INSGSLSIAR AKVKLPSTYS KLGNPLSFSK 
       710        720        730        740        750
FSLPDFNYSY DMIEELQQFF MKQRRCDYFS LLNNFINLLI SVSNLLAAEP 
       760        770        780        790        800
DIDLRNELLR RFIYSLNSWM NMRRCIVACC ENIFAMTGLC IPLESMSSST 
       810        820        830        840        850
FNHDTNNRLS YNNLQILHFN NEECKIFFSK KRAPYLLMFE VADLDEDISH 
       860        870        880        890        900
ISDNIFYTKK SLFFQQDNNN NNNNDNNNNN NNNNNNNNNY NCNNNNYNSD 
       910        920        930        940        950
VQSKEPKNVR EEYSRKSLIL SRNFCCSKNY GYYEENLNTF DYENRLSLED 
       960        970        980        990       1000
KKKKNSKKKK YAKEQEQTNN EKLKDKEKER KKKNIFDLNS LKMDDIYVYN 
      1010       1020       1030       1040       1050
CIVNDLRREN LISFTSKEDE NLALIKKCLG LKMVEEEKNE NDDDDNDDDN 
      1060       1070       1080       1090       1100
DDDNDDDNDD YNEEEEDDNY EKKNFEEEQK GNYNNDNINH NEKKKKVPTA 
      1110       1120       1130       1140       1150
NDNLSSSSFC VKKNYLLNSR SVSMPSYLNN NLEKCDTSSY DNTSNNIKTS 
      1160       1170       1180       1190       1200
IETISNGIDD IQVEKNIEKN ETFEEMKRKN SNNEFIDYNE HMVKLSPYYT 
      1210       1220       1230       1240       1250
TTNHRGKNKN DDTDDNSDDD NINNYNNNNN SGNNNQDNTI SNFPNNILDL 
      1260       1270       1280       1290       1300
SEYFKPENYL NEEFKKKNCK IIKRLLWGEL FEEKKKRIRK VSPYGKLKTW 
      1310       1320       1330       1340       1350
DLKCVIIKGG DDLRQELLAS QLIKQFKIIF ENAGLPLWLR PYEILVTGSN 
      1360       1370       1380       1390       1400
SGIIEYVNDT CSVDSLKRKF GADSISTIFN IVFSDYIFEA KKNFIESHAA 
      1410       1420       1430       1440       1450
YSLISYLLQV KDRHNGNLLL DSDGHLIHID YGFMLTNSPG NVNFETSPFK 
      1460       1470       1480       1490       1500
LTQEYLDIMD GEKSDNYEYF RRLIVSGFLE ARKHSEEIIL FVELMMPALK 
      1510       1520       1530       1540       1550
IPCFANGTQF CIESLKERFM TNLTVDVCIQ RINALIEASI NNFRSVQYDY 

FQRITNGIM
Length:1,559
Mass (Da):182,664
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9087140E1E176E96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL844504 Genomic DNA Translation: CAD51463.1

NCBI Reference Sequences

More...RefSeqi		XP_001351656.1, XM_001351620.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CAD51463; CAD51463; PF3D7_0509800

Database of genes from NCBI RefSeq genomes

More...GeneIDi		812838

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pfa:PF3D7_0509800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844504 Genomic DNA Translation: CAD51463.1
RefSeqiXP_001351656.1, XM_001351620.1

3D structure databases

AlphaFoldDBiQ8I406
SMRiQ8I406
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I406, 1 interactor
STRINGi5833.PFE0485w

Chemistry databases

GuidetoPHARMACOLOGYi2972

Proteomic databases

PRIDEiQ8I406

Genome annotation databases

EnsemblProtistsiCAD51463; CAD51463; PF3D7_0509800
GeneIDi812838
KEGGipfa:PF3D7_0509800

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0509800

Phylogenomic databases

HOGENOMiCLU_003809_0_0_1
InParanoidiQ8I406
OMAiYNCIVND
PhylomeDBiQ8I406

Enzyme and pathway databases

ReactomeiR-PFA-1660514, Synthesis of PIPs at the Golgi membrane

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR015433, PI_Kinase
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454, PI3_PI4_kinase, 2 hits
SMARTiView protein in SMART
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51545, PIK_HELICAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I406_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I406
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 25, 2022
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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