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Entry version 129 (22 Apr 2020)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Phosphatidylinositol 4-kinase

Gene

PF3D7_0509800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotationImported, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-1660514 Synthesis of PIPs at the Golgi membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphatidylinositol 4-kinaseImported (EC:2.7.1.67Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0509800Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0509800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I406, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I406

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini284 – 484PIK helicalInterPro annotationAdd BLAST201
Domaini1303 – 1559PI3K/PI4KInterPro annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 169DisorderedSequence analysisAdd BLAST94
Regioni275 – 314DisorderedSequence analysisAdd BLAST40
Regioni567 – 589DisorderedSequence analysisAdd BLAST23
Regioni867 – 909DisorderedSequence analysisAdd BLAST43
Regioni952 – 978DisorderedSequence analysisAdd BLAST27
Regioni1037 – 1102DisorderedSequence analysisAdd BLAST66
Regioni1200 – 1240DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili222 – 249Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi76 – 96PolyampholyteSequence analysisAdd BLAST21
Compositional biasi115 – 155AcidicSequence analysisAdd BLAST41
Compositional biasi867 – 903PolarSequence analysisAdd BLAST37
Compositional biasi960 – 978PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1038 – 1072AcidicSequence analysisAdd BLAST35
Compositional biasi1220 – 1240PolarSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003809_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I406

KEGG Orthology (KO)

More...
KOi
K19801

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNCIVND

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I406-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDKDNNIT KENLNEVDIE NSQHPIIEEK NLKEEGVKDE GGKVFLKGEP
60 70 80 90 100
IHKHLYKHSY NTQVYKDEVT HMRLRNRENK NLNENNSDDN KKVNKKNGCV
110 120 130 140 150
DINMNEHTNK KEDGDDDDGD DDDGDDDDDD DDDDGDDDGD DDGDDDGDDG
160 170 180 190 200
DDDSNSNDDI KNNHKYNNDD YHKNMIKLHC TSPKKKEHSI NNNNIVSHNE
210 220 230 240 250
IEENLKDHTL ITNDEEKNIK IIEMYEKKLE NEEIKKQNKE DANENNKSQI
260 270 280 290 300
RESISKIFKE CPTSKPKIIN EINNETKYDN NNNNNNNNNN NNNNSNNNNK
310 320 330 340 350
NNNKNNNKNS SYNNYYYNNI YNCNNMKENN HIDGDKNNIY ETNNYSDSEK
360 370 380 390 400
NKSSDTEKNK LKLNNKNTLK EGSLLRLFRC EYFDTHLHIR YLYDRKEVGV
410 420 430 440 450
HEYLVNSLYT QRKYEDILFY LPQLSQISLV RYESSSLYRF LLEKASKSMH
460 470 480 490 500
FALKLSWLYH SIVEDNSSKY KDLAQRMIQE IEMAVVNCKP LNNECKSFEE
510 520 530 540 550
NKQSYLLDLA YPLLFKRKFI LKKIKTNEKL NKIKMYNKCL NNSYNSYTLK
560 570 580 590 600
NLHVSNPIEM DTTSFLRNHK NSNDSTLSQG LPNKSSNDDN CNVLKREDHQ
610 620 630 640 650
DVINISSEEN EERDINKNLK EEVTTLDDNK ISRENNLQNL QSEKKTPILK
660 670 680 690 700
RKNLKQAHTT PCPKLPPCYI INSGSLSIAR AKVKLPSTYS KLGNPLSFSK
710 720 730 740 750
FSLPDFNYSY DMIEELQQFF MKQRRCDYFS LLNNFINLLI SVSNLLAAEP
760 770 780 790 800
DIDLRNELLR RFIYSLNSWM NMRRCIVACC ENIFAMTGLC IPLESMSSST
810 820 830 840 850
FNHDTNNRLS YNNLQILHFN NEECKIFFSK KRAPYLLMFE VADLDEDISH
860 870 880 890 900
ISDNIFYTKK SLFFQQDNNN NNNNDNNNNN NNNNNNNNNY NCNNNNYNSD
910 920 930 940 950
VQSKEPKNVR EEYSRKSLIL SRNFCCSKNY GYYEENLNTF DYENRLSLED
960 970 980 990 1000
KKKKNSKKKK YAKEQEQTNN EKLKDKEKER KKKNIFDLNS LKMDDIYVYN
1010 1020 1030 1040 1050
CIVNDLRREN LISFTSKEDE NLALIKKCLG LKMVEEEKNE NDDDDNDDDN
1060 1070 1080 1090 1100
DDDNDDDNDD YNEEEEDDNY EKKNFEEEQK GNYNNDNINH NEKKKKVPTA
1110 1120 1130 1140 1150
NDNLSSSSFC VKKNYLLNSR SVSMPSYLNN NLEKCDTSSY DNTSNNIKTS
1160 1170 1180 1190 1200
IETISNGIDD IQVEKNIEKN ETFEEMKRKN SNNEFIDYNE HMVKLSPYYT
1210 1220 1230 1240 1250
TTNHRGKNKN DDTDDNSDDD NINNYNNNNN SGNNNQDNTI SNFPNNILDL
1260 1270 1280 1290 1300
SEYFKPENYL NEEFKKKNCK IIKRLLWGEL FEEKKKRIRK VSPYGKLKTW
1310 1320 1330 1340 1350
DLKCVIIKGG DDLRQELLAS QLIKQFKIIF ENAGLPLWLR PYEILVTGSN
1360 1370 1380 1390 1400
SGIIEYVNDT CSVDSLKRKF GADSISTIFN IVFSDYIFEA KKNFIESHAA
1410 1420 1430 1440 1450
YSLISYLLQV KDRHNGNLLL DSDGHLIHID YGFMLTNSPG NVNFETSPFK
1460 1470 1480 1490 1500
LTQEYLDIMD GEKSDNYEYF RRLIVSGFLE ARKHSEEIIL FVELMMPALK
1510 1520 1530 1540 1550
IPCFANGTQF CIESLKERFM TNLTVDVCIQ RINALIEASI NNFRSVQYDY

FQRITNGIM
Length:1,559
Mass (Da):182,664
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9087140E1E176E96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844504 Genomic DNA Translation: CAD51463.1

NCBI Reference Sequences

More...
RefSeqi
XP_001351656.1, XM_001351620.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD51463; CAD51463; PF3D7_0509800

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0509800.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
812838

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0509800

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844504 Genomic DNA Translation: CAD51463.1
RefSeqiXP_001351656.1, XM_001351620.1

3D structure databases

SMRiQ8I406
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I406, 1 interactor

Proteomic databases

PRIDEiQ8I406

Genome annotation databases

EnsemblProtistsiCAD51463; CAD51463; PF3D7_0509800
GeneDBiPF3D7_0509800.1:pep
GeneIDi812838
KEGGipfa:PF3D7_0509800

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0509800

Phylogenomic databases

HOGENOMiCLU_003809_0_0_1
InParanoidiQ8I406
KOiK19801
OMAiYNCIVND

Enzyme and pathway databases

ReactomeiR-PFA-1660514 Synthesis of PIPs at the Golgi membrane

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits
SMARTiView protein in SMART
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I406_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I406
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 22, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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