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UniProtKB - Q8I406 (Q8I406_PLAF7)
Protein
Submitted name:
Phosphatidylinositol 4-kinase
Gene
PF3D7_0509800
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- 1-phosphatidylinositol 4-kinase activity Source: GO_Central
- phosphatidylinositol kinase activity Source: GO_Central
GO - Biological processi
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol phosphate biosynthetic process Source: GO_Central
Keywordsi
Molecular function | KinasePROSITE-ProRule annotationARBA annotation, Transferase |
Enzyme and pathway databases
Reactomei | R-PFA-1660514, Synthesis of PIPs at the Golgi membrane |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_0509800Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0509800 |
Subcellular locationi
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 284 – 484 | PIK helicalInterPro annotationAdd BLAST | 201 | |
Domaini | 1303 – 1559 | PI3K/PI4K catalyticInterPro annotationAdd BLAST | 257 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 169 | DisorderedSequence analysisAdd BLAST | 94 | |
Regioni | 275 – 314 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 567 – 589 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 867 – 909 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 952 – 978 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1037 – 1102 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 1200 – 1240 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 1309 – 1315 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 1460 – 1484 | Activation loopPROSITE-ProRule annotationAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 222 – 249 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 76 – 96 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 115 – 155 | Acidic residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 867 – 903 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 960 – 978 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1038 – 1072 | Acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1220 – 1240 | Polar residuesSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_003809_0_0_1 |
InParanoidi | Q8I406 |
OMAi | YNCIVND |
PhylomeDBi | Q8I406 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 2 hits |
SMARTi | View protein in SMART SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I406-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDDKDNNIT KENLNEVDIE NSQHPIIEEK NLKEEGVKDE GGKVFLKGEP
60 70 80 90 100
IHKHLYKHSY NTQVYKDEVT HMRLRNRENK NLNENNSDDN KKVNKKNGCV
110 120 130 140 150
DINMNEHTNK KEDGDDDDGD DDDGDDDDDD DDDDGDDDGD DDGDDDGDDG
160 170 180 190 200
DDDSNSNDDI KNNHKYNNDD YHKNMIKLHC TSPKKKEHSI NNNNIVSHNE
210 220 230 240 250
IEENLKDHTL ITNDEEKNIK IIEMYEKKLE NEEIKKQNKE DANENNKSQI
260 270 280 290 300
RESISKIFKE CPTSKPKIIN EINNETKYDN NNNNNNNNNN NNNNSNNNNK
310 320 330 340 350
NNNKNNNKNS SYNNYYYNNI YNCNNMKENN HIDGDKNNIY ETNNYSDSEK
360 370 380 390 400
NKSSDTEKNK LKLNNKNTLK EGSLLRLFRC EYFDTHLHIR YLYDRKEVGV
410 420 430 440 450
HEYLVNSLYT QRKYEDILFY LPQLSQISLV RYESSSLYRF LLEKASKSMH
460 470 480 490 500
FALKLSWLYH SIVEDNSSKY KDLAQRMIQE IEMAVVNCKP LNNECKSFEE
510 520 530 540 550
NKQSYLLDLA YPLLFKRKFI LKKIKTNEKL NKIKMYNKCL NNSYNSYTLK
560 570 580 590 600
NLHVSNPIEM DTTSFLRNHK NSNDSTLSQG LPNKSSNDDN CNVLKREDHQ
610 620 630 640 650
DVINISSEEN EERDINKNLK EEVTTLDDNK ISRENNLQNL QSEKKTPILK
660 670 680 690 700
RKNLKQAHTT PCPKLPPCYI INSGSLSIAR AKVKLPSTYS KLGNPLSFSK
710 720 730 740 750
FSLPDFNYSY DMIEELQQFF MKQRRCDYFS LLNNFINLLI SVSNLLAAEP
760 770 780 790 800
DIDLRNELLR RFIYSLNSWM NMRRCIVACC ENIFAMTGLC IPLESMSSST
810 820 830 840 850
FNHDTNNRLS YNNLQILHFN NEECKIFFSK KRAPYLLMFE VADLDEDISH
860 870 880 890 900
ISDNIFYTKK SLFFQQDNNN NNNNDNNNNN NNNNNNNNNY NCNNNNYNSD
910 920 930 940 950
VQSKEPKNVR EEYSRKSLIL SRNFCCSKNY GYYEENLNTF DYENRLSLED
960 970 980 990 1000
KKKKNSKKKK YAKEQEQTNN EKLKDKEKER KKKNIFDLNS LKMDDIYVYN
1010 1020 1030 1040 1050
CIVNDLRREN LISFTSKEDE NLALIKKCLG LKMVEEEKNE NDDDDNDDDN
1060 1070 1080 1090 1100
DDDNDDDNDD YNEEEEDDNY EKKNFEEEQK GNYNNDNINH NEKKKKVPTA
1110 1120 1130 1140 1150
NDNLSSSSFC VKKNYLLNSR SVSMPSYLNN NLEKCDTSSY DNTSNNIKTS
1160 1170 1180 1190 1200
IETISNGIDD IQVEKNIEKN ETFEEMKRKN SNNEFIDYNE HMVKLSPYYT
1210 1220 1230 1240 1250
TTNHRGKNKN DDTDDNSDDD NINNYNNNNN SGNNNQDNTI SNFPNNILDL
1260 1270 1280 1290 1300
SEYFKPENYL NEEFKKKNCK IIKRLLWGEL FEEKKKRIRK VSPYGKLKTW
1310 1320 1330 1340 1350
DLKCVIIKGG DDLRQELLAS QLIKQFKIIF ENAGLPLWLR PYEILVTGSN
1360 1370 1380 1390 1400
SGIIEYVNDT CSVDSLKRKF GADSISTIFN IVFSDYIFEA KKNFIESHAA
1410 1420 1430 1440 1450
YSLISYLLQV KDRHNGNLLL DSDGHLIHID YGFMLTNSPG NVNFETSPFK
1460 1470 1480 1490 1500
LTQEYLDIMD GEKSDNYEYF RRLIVSGFLE ARKHSEEIIL FVELMMPALK
1510 1520 1530 1540 1550
IPCFANGTQF CIESLKERFM TNLTVDVCIQ RINALIEASI NNFRSVQYDY
FQRITNGIM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844504 Genomic DNA Translation: CAD51463.1 |
RefSeqi | XP_001351656.1, XM_001351620.1 |
Genome annotation databases
EnsemblProtistsi | CAD51463; CAD51463; PF3D7_0509800 |
GeneIDi | 812838 |
KEGGi | pfa:PF3D7_0509800 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844504 Genomic DNA Translation: CAD51463.1 |
RefSeqi | XP_001351656.1, XM_001351620.1 |
3D structure databases
AlphaFoldDBi | Q8I406 |
SMRi | Q8I406 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8I406, 1 interactor |
STRINGi | 5833.PFE0485w |
Chemistry databases
GuidetoPHARMACOLOGYi | 2972 |
Proteomic databases
PRIDEi | Q8I406 |
Genome annotation databases
EnsemblProtistsi | CAD51463; CAD51463; PF3D7_0509800 |
GeneIDi | 812838 |
KEGGi | pfa:PF3D7_0509800 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0509800 |
Phylogenomic databases
HOGENOMi | CLU_003809_0_0_1 |
InParanoidi | Q8I406 |
OMAi | YNCIVND |
PhylomeDBi | Q8I406 |
Enzyme and pathway databases
Reactomei | R-PFA-1660514, Synthesis of PIPs at the Golgi membrane |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 2 hits |
SMARTi | View protein in SMART SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I406_PLAF7 | |
Accessioni | Q8I406Primary (citable) accession number: Q8I406 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |