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Entry version 86 (22 Apr 2020)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Nucleoporin NUP221, putative

Gene

PF3D7_0905100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nucleoporin NUP221, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0905100Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0905100

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1228 – 1251HelicalSequence analysisAdd BLAST24
Transmembranei1263 – 1279HelicalSequence analysisAdd BLAST17
Transmembranei1317 – 1339HelicalSequence analysisAdd BLAST23
Transmembranei1678 – 1696HelicalSequence analysisAdd BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8I398

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8I398

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8I398, 7 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8I398

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 410DisorderedSequence analysisAdd BLAST63
Regioni579 – 604DisorderedSequence analysisAdd BLAST26
Regioni748 – 772DisorderedSequence analysisAdd BLAST25
Regioni1040 – 1142DisorderedSequence analysisAdd BLAST103
Regioni1437 – 1483DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1063 – 1081BasicSequence analysisAdd BLAST19
Compositional biasi1091 – 1125AcidicSequence analysisAdd BLAST35
Compositional biasi1444 – 1459PolarSequence analysisAdd BLAST16

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_232613_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8I398

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEYCNIE

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025574 Nucleoporin_FG_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13634 Nucleoporin_FG, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8I398-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNQNFNNSN LNKGNFQDSN NLLKNKNMFM QNSSQNNNIF GTFNQNNNTN
60 70 80 90 100
KSLFGNSNLQ SNIGNTDNSL FGGSKIQQPN NALVNKSIFN LGGSSGTSTG
110 120 130 140 150
LSGGKSIYDN MNSQSNLNTK NIFGSTNVSN NTQGNMGGNS LFMNANNQNN
160 170 180 190 200
LNMKNIFGSS SGLNNQTSNL GNKSIFGGLQ PSNQTTPSNN IFGNMSSNQT
210 220 230 240 250
NSSNIFGNLS STSQNKSNSI FGGLGTSTNQ STGGGLFGNT GATSQNKTGG
260 270 280 290 300
IFGGLSSTNQ ASTSSTSMFG GLSSNQAKPT NSLFGGLSSG ATSNTGTQQS
310 320 330 340 350
GNLFGSASGI GQSKTVGGIF GNLSSTNQAS TSSSNMFGGL SSNQAKPTSS
360 370 380 390 400
LFGGLSSGTT TNTSTQQSGN LFGSATGLGQ NKTGGGIFGT LPSANQTSTT
410 420 430 440 450
SSNMFGGLST NQAKPTSSLF GGMSSGTTGI TTNTTAQSGN LFGGTGTSQN
460 470 480 490 500
KTGNLFGALP GANQTSTTSN IFGGLSSAQS KPTSNIFGTM GTVSATTTAA
510 520 530 540 550
STSSNIFGST GGLNQSKPST GNVFGSLQTM TQPGSTNMFG TTQGTSQGLT
560 570 580 590 600
STNMFSSSTV PGSSQNKFTN MFGTLSGTTG STPMGTLTTP NSTTTATTGL
610 620 630 640 650
TGTGVGGTSG TSNIFGNVSG GSSFGNLSAN KNIFGSTGTG MTLSTASTSL
660 670 680 690 700
SPSVGTSLGQ NLGGAMTSTL NTNLTTPGFG QSGGSNIFGN LGGTVTSNIG
710 720 730 740 750
STITPTPSSS TLLGSTLTSG LSTTTDTASK NFLLGDKNAL TISPLGGTST
760 770 780 790 800
LPTSSTNLTM QTGTGLTSST PNILINDQPR VVSNLNLVNE LKRDKESNLR
810 820 830 840 850
STDNFHGLHD ELTITKKKES IFDKIYNDDI DNEEEEEEDE EGGSSGGLFY
860 870 880 890 900
NYINLIINDN INNIQKSTLT LLNDHDSLMW DNFKSHIFKN FVDYLVNFKQ
910 920 930 940 950
KKNQKMIKGN VLDLDQHEFQ ILIWLYNVNS TKLNFIPFKS FYYLLLSETN
960 970 980 990 1000
LNYSKVLIGG SDKKILLDNF IEVNDHYYIN SNNDIFKSQL NKYRNSSLHR
1010 1020 1030 1040 1050
DEYNSSLDID SMYKQLLKDI LNSLLNMNLS ITKENIRKNT KTENLKNGNE
1060 1070 1080 1090 1100
GKGAGLEIKK KRVDEKKKKK PTRGKKKKRV AKYKSEVNED SYENDDNDEN
1110 1120 1130 1140 1150
VNDNDNDESV GDNDESVDDN DKSVDDNDQS DYNNDQSYDD NVENNINTRK
1160 1170 1180 1190 1200
MVRVPQFRYE NILLNYLFGT LQHLHDKFYK IEISNYVSKD LNQIDEYFFD
1210 1220 1230 1240 1250
SKSNAIFSYC YNNFYKNEMD KENSTIHFFF YLVNIMFRCG NYVGLIQIIK
1260 1270 1280 1290 1300
LEEFIKNLNI DNYLYDFVIL LIRILLLIYN KKNTMNIFEN MKVDIDCSDI
1310 1320 1330 1340 1350
FKKKIHMSNI INFFHSIIYL CINNIYAYDL LCILFSDIFC KKGNMYTNRD
1360 1370 1380 1390 1400
KKIAMKNIFF YIRKKNVTIN NNNNNNNNTS SSNHNNNYIN HGASIFHSVS
1410 1420 1430 1440 1450
DDDLLADKNY IKEIRNRHMN YDYNNDKIMM NGSLRKNRRH ANNSNKDGNI
1460 1470 1480 1490 1500
YYNDTINDSS NDDYGEDEAD DGYNSRDHDK PNKKKKPFFF DMISNMLQKP
1510 1520 1530 1540 1550
KTVKGYENDF NNGMDINDEV NKGIYNLRKS TFSKNPNDIY LGVTNRHAFN
1560 1570 1580 1590 1600
FQYCNIETSI WIELCLFLSK NFNIYGSKFI DNFDIIDTDV LYCDEENVSH
1610 1620 1630 1640 1650
INDTKCRRER INKRIEVLFI TISNYIISEN KEYLYICSKL KVDEVMNNFL
1660 1670 1680 1690 1700
INDGKISEKL KGNINKVLKN NFLLYIKLFY YLLLVGNIYT TIVFLSCVSN
1710 1720 1730 1740 1750
NVQRILLVLS IFLHNNNIFE NHLLNNIKMK TLQYLKFRND HNSILDTSHD
1760 1770 1780 1790 1800
ITDVQNSENK FNLILLSMSN VDLPFDHFVL RNNNINILLK ITYLLNLKTN
1810 1820 1830 1840 1850
ISIKLLKSIV QENQDVLLHE SVIGHINNDG NIFYGKLHDF LFLFKNKIKI
1860 1870 1880 1890 1900
RKDIKCFFLM YYILYKQNVS NNILLKTRQN EMDDEYLYKS RNFKFVHNKN
1910 1920 1930 1940 1950
INTLNKISLD NSLISVHSSI LYKISQFYAI LAYFANQRKN YIISFICYYI
1960 1970 1980 1990 2000
LKDEDSAINS LIRIYNDELI YYFHNNEKEY NYIRKCAFRF FHLAKNMWPS
2010 2020 2030 2040 2050
NVKLESIENK SYLILCILFM KKKLFEEAFV IFSTNLVPDN MLEKLSTADY
2060 2070 2080 2090 2100
YNIDLSSNFL MTLKELCTQN YRIDELVSKP ALKAIIKFLN PIKDKLDPQI
2110
VESINYLDEI NY
Length:2,112
Mass (Da):235,538
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1AA67999BD6F996
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD51736.1

NCBI Reference Sequences

More...
RefSeqi
XP_001351925.1, XM_001351889.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAD51736; CAD51736; PF3D7_0905100

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0905100.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
813330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0905100

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAD51736.1
RefSeqiXP_001351925.1, XM_001351889.1

3D structure databases

SMRiQ8I398
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8I398, 7 interactors

PTM databases

SwissPalmiQ8I398

Proteomic databases

PRIDEiQ8I398

Genome annotation databases

EnsemblProtistsiCAD51736; CAD51736; PF3D7_0905100
GeneDBiPF3D7_0905100.1:pep
GeneIDi813330
KEGGipfa:PF3D7_0905100

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0905100

Phylogenomic databases

HOGENOMiCLU_232613_0_0_1
InParanoidiQ8I398
OMAiFEYCNIE

Family and domain databases

InterProiView protein in InterPro
IPR025574 Nucleoporin_FG_rpt
PfamiView protein in Pfam
PF13634 Nucleoporin_FG, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8I398_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8I398
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 22, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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