UniProtKB - Q8I2X3 (Q8I2X3_PLAF7)
Protein
Acid phosphatase
Gene
PF3D7_0918000
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
- EC:3.1.3.2ARBA annotation
Cofactori
Fe cationARBA annotation
GO - Molecular functioni
- acid phosphatase activity Source: GO_Central
- ferric iron binding Source: GO_Central
- ferrous iron binding Source: GO_Central
- phosphoprotein phosphatase activity Source: UniProtKB-KW
- protein-membrane adaptor activity Source: GeneDB
Keywordsi
Molecular function | Hydrolase, Protein phosphataseARBA annotation |
Enzyme and pathway databases
Reactomei | R-PFA-196843, Vitamin B2 (riboflavin) metabolism |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_0918000Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_0918000 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 23 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 367 – 391 | HelicalSequence analysisAdd BLAST | 25 |
GO - Cellular componenti
- endoplasmic reticulum Source: GeneDB
- inner membrane pellicle complex Source: GeneDB
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: GeneDB
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 257 | MetallophosInterPro annotationAdd BLAST | 230 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_699224_0_0_1 |
InParanoidi | Q8I2X3 |
OMAi | LKYWTNP |
PhylomeDBi | Q8I2X3 |
Family and domain databases
CDDi | cd07378, MPP_ACP5, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR024927, Acid_PPase IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8I2X3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYCKTTFHI FFFVLFFITI YEIKCQLRFA SLGDWGKDTK GQILNAKYFK
60 70 80 90 100
QFIKNERVTF IVSPGSNFID GVKGLNDPAW KNLYEDVYSE EKGDMYMPFF
110 120 130 140 150
TVLGTRDWTG NYNAQLLKGQ GIYIEKNGET SIEKDADATN YPKWIMPNYW
160 170 180 190 200
YHYFTHFTVS SGPSIVKTGH KDLAAAFIFI DTWVLSSNFP YKKIHEKAWN
210 220 230 240 250
DLKSQLSVAK KIADFIIVVG DQPIYSSGYS RGSSYLAYYL LPLLKDAEVD
260 270 280 290 300
LYISGHDNNM EVIEDNDMAH ITCGSGSMSQ GKSGMKNSKS LFFSSDIGFC
310 320 330 340 350
VHELSNNGIV TKFVSSKKGE VIYTHKLNIK KKKTLDKVNA LQHFAALPNV
360 370 380 390
ELTDVPSSGP MGNKDTFVRV VGTIGILIGS VIVFIGASSF LSKNMK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844508 Genomic DNA Translation: CAD51862.1 |
RefSeqi | XP_001352051.1, XM_001352015.1 |
Genome annotation databases
EnsemblProtistsi | CAD51862; CAD51862; PF3D7_0918000 |
GeneDBi | PF3D7_0918000.1:pep |
GeneIDi | 813456 |
KEGGi | pfa:PF3D7_0918000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844508 Genomic DNA Translation: CAD51862.1 |
RefSeqi | XP_001352051.1, XM_001352015.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3TGH | X-ray | 1.70 | A | 24-365 | [»] | |
SMRi | Q8I2X3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
PTM databases
SwissPalmi | Q8I2X3 |
Proteomic databases
PRIDEi | Q8I2X3 |
Genome annotation databases
EnsemblProtistsi | CAD51862; CAD51862; PF3D7_0918000 |
GeneDBi | PF3D7_0918000.1:pep |
GeneIDi | 813456 |
KEGGi | pfa:PF3D7_0918000 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_0918000 |
Phylogenomic databases
HOGENOMi | CLU_699224_0_0_1 |
InParanoidi | Q8I2X3 |
OMAi | LKYWTNP |
PhylomeDBi | Q8I2X3 |
Enzyme and pathway databases
Reactomei | R-PFA-196843, Vitamin B2 (riboflavin) metabolism |
Family and domain databases
CDDi | cd07378, MPP_ACP5, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR024927, Acid_PPase IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8I2X3_PLAF7 | |
Accessioni | Q8I2X3Primary (citable) accession number: Q8I2X3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |